Dried Plums and Bone Health in Postmenopausal Women

Korábbi kezelés

• Women who regularly consume dried plums, dried apples, prune juice, or heavy consumers of blueberries (1 cup or more/day). Potential volunteers who will refrain from consumption of the afore mentioned foods for the duration of the study will become eligible after a 2 month washout period;
• Participants who will not consume study therapy or will not stop taking natural product supplements of their own selection.

Más betegség

• history of spinal stenosis;
• history of heart attack, stroke, thromboembolism, kidney disease, malabsorption syndrome, seizure disorders;
• positive for HIV, Hep-C or Hep-B surface antigen and malignancy.

Laborértékek

• significantly impaired renal function; high potassium

Életkor

• history of vertebral fracture or fragility fracture of the wrist, humerus, hip or pelvis after age 50 yr);

Egyéb

• vitamin D deficiency (<20 ng/mL);
• untreated hyper- or hypothyroidism;
• current hyper- or hypoparathyroidism;
• current hypo- or hypercalcemia;
• Use of the following agents affecting bone metabolism:
  • intravenous bisphosphonates at any time;
  • fluoride (for osteoporosis) within the past 24 months;
  • denosumab at any time;
  • bisphosphonates, parathyroid hormone or strontium within the past 12 months;
  • calcitonin or selective estrogen receptor modulators within the past 12 months;
  • systemic oral or transdermal estrogen within the past 3 months;
  • systemic glucocorticosteroids (≥ 5 mg prednisone equivalent per day for more than 10 days); or
  • tibolone within the past 3 months.

• Postmenopausal women
• not severely obese (BMI < 40 kg/m2);
• healthy (determined by a screening questionnaire, complete metabolic panel);
• willing to include dried plums in their daily diet;
• not taking any natural dietary supplement containing phenolics, blueberries or apples for at least 2 months prior to study entry; can stop for 2 months to meet entry criteria
• non-smoking; ambulatory;
• low BMD as measured by dual energy X-ray absorptiometry (DXA). Eligible BMD values (T-scores) for DXA measures of the lumbar spine, total hip and/or femoral neck will correspond to T-scores between 0 and -3.0.