Implantable Cardioverter Defibrillator Versus Optimal Medical Therapy In Patients With Variant Angina Manifesting as Aborted Sudden Cardiac Death

Korábbi kezelés

• prior history of atrial or ventricular arrhythmia requiring class I or III antiarrhythmic drugs (flecainide, propafenone, amiodarone, sotalol and dronedarone)
• Prior catheter ablation for ventricular arrhythmia
• Prior pacemaker or Implantable Cardioverter Defibrillator

Más betegség

• Chronic Heart Failure New York Heart Association functional class III or IV
• Psychiatric illnesses that may be aggravated by device implantation or that may preclude systematic follow-up

Laborértékek

• Organic heart disease known to be associated with sudden cardiac arrest.
  • Heart failure with reduced ejection fraction (Left Ventricular Ejection Fraction < 35%)
  • Presence of LV akinesia or aneurysm
  • Hypertrophic cardiomyopathy
  • Arrhythmogenic right ventricular dysplasia
• Primary cardiac electrical diseases (long QT syndrome, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia)

Életkor

• Life expectancy <2 years

Egyéb

• Significant (>50%) coronary artery stenosis on coronary angiography
• 2nd or 3rd degree AV block not related to coronary ischemia, requiring permanent pacemaker
• Patients with poor neurologic outcome (defined as cerebral performance category scale ≥3)

• Age 18 years or older
• Patients experienced successfully resuscitated cardiac arrest due to documented ventricular fibrillation or sustained rapid ventricular tachycardia
• Diagnosed as variant angina, defined by spontaneous coronary spasm with ST elevation (≥0.1mV) in the coronary angiogram and/or documented coronary spasm on ergonovine provocation coronary angiography