Transarterial Radioembolisation in Comparison to Transarterial Chemoembolisation in Uveal Melanoma Liver Metastasis

Korábbi kezelés

• Previous intraarterial hepatic treatment (e.g. radioembolisation, chemoembolisation, intraarterial chemotherapy, isolated or percutaneous hepatic perfusion)
• Previous treatment with external liver radiation
• Current treatment with any anti-cancer therapy

Más betegség

• Progressive liver failure
• Renale failure, bone marrow insufficiency, coagulopathy
• Uncontrolled or severe medical conditions which could impair the ability to participate in the trial such as unstable cardiac disease or uncontrolled infection
• Other malignancy and/or metastases in need of treatment

Egyéb

• Surgically treatable liver metastases
• Major intrahepatic occlusion of the portal vein and/or tumor infiltration of the portal vein
• Liver cirrhosis Child-Pugh C

• ECOG Performance Status of 0, 1 or 2
• Histologically or cytologically confirmed liver metastases of uveal melanoma
• At least one measurable lesion according to RECIST criteria v1.1 determined MRI (if contraindications against MRI exist CT with contrast media can is allowed)
• Metastases in other sides are allowed if not in need of treatment (e.g. asymptomatic bone metastasis without indication for radiation)
• Prior treatment with systemic anti-cancer therapy is allowed if terminated ≥ 4 weeks prior to study treatment start and recovery from toxicity is achieved
• Surgery in general and hepatic surgery in particular (e.g. lobe resection, radiofrequency ablation) prior to study enrollment are allowed if realized ≥ 4 weeks prior to study enrollment and recovery from surgery is achieved