Taking people in Egyesült Államok3. fázis

Inotuzumab Ozogamicin and Frontline Chemotherapy in Treating Young Adults With Newly Diagnosed B Acute Lymphoblastic Leukemia

Key facts

Where: ‘Aiea, Aberdeen, Aitkin, Albuquerque, Allentown, Alton, American Fork, Anaconda, Anchorage, Ann Arbor, Antioch, Arroyo Grande, Ashland, Atlanta, Augusta, Aurora, Baker City, Ballwin, Baltimore, Baton Rouge, Battle Creek, Bellevue, Bellingham, Bend, Bethlehem, Billings, Birmingham, Boiling Springs, Boise, Bolivar, Boston, Boulder, Bozeman, Brainerd, Branson, Brighton, Buffalo, Burbank, Burnsville, Burr Ridge, Butte, Caldwell, Cambridge, Canton, Caro, Carroll, Carson City, Cedar City, Centennial, Centralia, Chapel Hill, Chelsea, Cheyenne, Chicago, Cincinnati, City of Saint Peters, Clackamas, Clarkston, Cleveland, Clinton, Clovis, Cody, Coeur d'Alene, Columbia, Columbus, Coon Rapids, Coos Bay, Costa Mesa, Creve Coeur, Deer River, Denver, Des Moines, Detroit, Detroit Lakes, Dublin, Duluth, Durham, Easley, East China Township, East Stroudsburg, Edina, Edmonds, Emmett, Englewood, Evanston, Everett, Fairbanks, Fairfax, Falls Church, Fargo, Farmington Hills, Fergus Falls, Flint, Fort Dodge, Fort Lauderdale, Fort Smith, Fosston, Fremont, Fresno, Fridley, Fruitland, Garden City, Glenview, Golden, Grand Junction, Grand Rapids, Great Bend, Great Falls, Greeley, Greenville, Greer, Grosse Pointe Woods, Hartford, Hayward, Hazleton, Henderson, Hibbing, Highland Park, Hilo, Hollywood, Homer Glen, Honolulu, Houston, Iowa City, Irvine, Issaquah, Jamestown, Joplin, Kalamazoo, Kalispell, Kansas City, Kennewick, Kingman, Lacey, Lafayette, Lake Forest, Lake Success, Lakewood, Lansing, Las Vegas, Lawrence, Lexington, Lihue, Lisle, Littleton, Livonia, Logan, Lone Tree, Longview, Loveland, Lubbock, Macomb, Madison, Manhasset, Maple Grove, Maplewood, Marlette, Marshfield, Maywood, Melrose Park, Meridian, Miami, Milwaukee, Minneapolis, Missoula, Modesto, Monticello, Mount Vernon, Murray, Muskegon, Nampa, New Haven, New Hyde Park, New Lenox, New Orleans, New Richmond, New Ulm, New York, Newberg, Niles, Norton Shores, Oakland, Ogden, Oklahoma City, Omaha, Ontario, Orange, Orland Park, Orlando, Pahrump, Palo Alto, Park Rapids, Pembroke Pines, Philadelphia, Phoenix, Pittsburgh, Pontiac, Port Townsend, Portland, Post Falls, Princeton, Providence, Provo, Rancho Cordova, Redmond, Redwood City, Reed City, Reno, Renton, Richmond, Riverton, Robbinsdale, Rochester, Rochester Hills, Rohnert Park, Rolla, Roseville, Sacramento, Saginaw, Saint Joseph, Saint Louis Park, Saint Paul, Salt Lake City, San Francisco, San Jose, San Leandro, San Rafael, Sandpoint, Sandstone, Santa Clara, Santa Rosa, Scottsdale, Seattle, Sedro-Woolley, Seneca, Shakopee, Shelton, Sheridan, South San Francisco, Spooner, Springfield, St Louis, St. George, Sterling Heights, Stillwater, Stockton, Stony Brook, Superior, Syracuse, Tawas City, Thornton, Traverse City, Twin Falls, Vacaville, Vallejo, Vancouver, Verona, Virginia, Waconia, Walla Walla, Walnut Creek, Warren, Washington, West Branch, West Chester, West Des Moines, Westwood, Wheat Ridge, Wichita, Willmar, Winston-Salem, Woodbury, Wyoming, Yakima, Yelm és Ypsilanti, Egyesült ÁllamokSee the 455 sites
Phase: 3. fázis

Could this be for you?

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

Are you between 18 and 39 years old?

Forrás: NCT03150693: ki vehet részt

Where in Egyesült Államok

Pali Momi Medical Center‘Aiea, Egyesült ÁllamokTaking people
Hawaii Cancer Care - Westridge‘Aiea, Egyesült ÁllamokNo longer taking part
Queen's Cancer Center - Pearlridge‘Aiea, Egyesült ÁllamokNo longer taking part
The Cancer Center of Hawaii-Pali Momi‘Aiea, Egyesült ÁllamokNo longer taking part
Providence Regional Cancer System-AberdeenAberdeen, Egyesült ÁllamokNo longer taking part
Riverwood Healthcare CenterAitkin, Egyesült ÁllamokNo longer taking part
University of New Mexico Cancer CenterAlbuquerque, Egyesült ÁllamokNo longer taking part
Lehigh Valley Hospital-Cedar CrestAllentown, Egyesült ÁllamokTaking people
OSF Saint Anthony's Health CenterAlton, Egyesült ÁllamokNo longer taking part
American Fork Hospital / Huntsman Intermountain Cancer CenterAmerican Fork, Egyesült ÁllamokNo longer taking part
Community Hospital of AnacondaAnaconda, Egyesült ÁllamokTaking people
Alaska Breast Care and Surgery LLCAnchorage, Egyesült ÁllamokNo longer taking part
Alaska Oncology and Hematology LLCAnchorage, Egyesült ÁllamokNo longer taking part
Alaska Women's Cancer CareAnchorage, Egyesült ÁllamokNo longer taking part
Anchorage Associates in Radiation MedicineAnchorage, Egyesült ÁllamokNo longer taking part
Anchorage Oncology CentreAnchorage, Egyesült ÁllamokNo longer taking part
Anchorage Radiation Therapy CenterAnchorage, Egyesült ÁllamokNo longer taking part
Katmai Oncology GroupAnchorage, Egyesült ÁllamokNo longer taking part
Providence Alaska Medical CenterAnchorage, Egyesült ÁllamokNo longer taking part
Trinity Health Saint Joseph Mercy Hospital Ann ArborAnn Arbor, Egyesült ÁllamokTaking people
Kaiser Permanente-Deer Valley Medical CenterAntioch, Egyesült ÁllamokTaking people
PCR OncologyArroyo Grande, Egyesült ÁllamokNo longer taking part
Duluth Clinic AshlandAshland, Egyesült ÁllamokNo longer taking part
Northwest Wisconsin Cancer CenterAshland, Egyesült ÁllamokNo longer taking part
Emory University Hospital/Winship Cancer InstituteAtlanta, Egyesült ÁllamokTaking people
Augusta University Medical CenterAugusta, Egyesült ÁllamokTaking people
Rocky Mountain Cancer Centers-AuroraAurora, Egyesült ÁllamokNo longer taking part
The Medical Center of AuroraAurora, Egyesült ÁllamokNo longer taking part
Saint Alphonsus Cancer Care Center-Baker CityBaker City, Egyesült ÁllamokNo longer taking part
Mercy Oncology and Hematology - Clayton-ClarksonBallwin, Egyesült ÁllamokNo longer taking part
University of Maryland/Greenebaum Cancer CenterBaltimore, Egyesült ÁllamokTaking people
Medical Center of Baton RougeBaton Rouge, Egyesült ÁllamokNo longer taking part
Ochsner Health Center-SummaBaton Rouge, Egyesült ÁllamokNo longer taking part
Ochsner High GroveBaton Rouge, Egyesült ÁllamokNo longer taking part
Bronson Battle CreekBattle Creek, Egyesült ÁllamokNo longer taking part
Nebraska Medicine-BellevueBellevue, Egyesült ÁllamokTaking people
Overlake Medical CenterBellevue, Egyesült ÁllamokNo longer taking part
PeaceHealth Saint Joseph Medical CenterBellingham, Egyesült ÁllamokNo longer taking part
Saint Charles Health SystemBend, Egyesült ÁllamokNo longer taking part
Lehigh Valley Hospital - MuhlenbergBethlehem, Egyesült ÁllamokTaking people
Billings Clinic Cancer CenterBillings, Egyesült ÁllamokTaking people
Saint Vincent Frontier Cancer CenterBillings, Egyesült ÁllamokNo longer taking part
Saint Vincent HealthcareBillings, Egyesült ÁllamokNo longer taking part
University of Alabama at Birmingham Cancer CenterBirmingham, Egyesült ÁllamokNo longer taking part
Prisma Health Cancer Institute - SpartanburgBoiling Springs, Egyesült ÁllamokTaking people
Saint Alphonsus Cancer Care Center-BoiseBoise, Egyesült ÁllamokTaking people
Saint Luke's Cancer Institute - BoiseBoise, Egyesült ÁllamokTaking people
Central Care Cancer Center - BolivarBolivar, Egyesült ÁllamokNo longer taking part
Beth Israel Deaconess Medical CenterBoston, Egyesült ÁllamokNo longer taking part
Dana-Farber Cancer InstituteBoston, Egyesült ÁllamokNo longer taking part
Massachusetts General Hospital Cancer CenterBoston, Egyesült ÁllamokNo longer taking part
Boulder Community Foothills HospitalBoulder, Egyesült ÁllamokNo longer taking part
Rocky Mountain Cancer Centers-BoulderBoulder, Egyesült ÁllamokNo longer taking part
Bozeman Health Deaconess HospitalBozeman, Egyesült ÁllamokTaking people
Essentia Health Saint Joseph's Medical CenterBrainerd, Egyesült ÁllamokNo longer taking part
Cox Cancer Center BransonBranson, Egyesült ÁllamokNo longer taking part
Trinity Health IHA Medical Group Hematology Oncology - BrightonBrighton, Egyesült ÁllamokTaking people
Trinity Health Medical Center - BrightonBrighton, Egyesült ÁllamokTaking people
Roswell Park Cancer InstituteBuffalo, Egyesült ÁllamokTaking people
Providence Saint Joseph Medical Center/Disney Family Cancer CenterBurbank, Egyesült ÁllamokNo longer taking part
Fairview Ridges HospitalBurnsville, Egyesült ÁllamokNo longer taking part
Minnesota Oncology - BurnsvilleBurnsville, Egyesült ÁllamokNo longer taking part
Loyola Center for Health at Burr RidgeBurr Ridge, Egyesült ÁllamokNo longer taking part
Saint James Community Hospital and Cancer Treatment CenterButte, Egyesült ÁllamokNo longer taking part
Saint Alphonsus Cancer Care Center-CaldwellCaldwell, Egyesült ÁllamokTaking people
Cambridge Medical CenterCambridge, Egyesült ÁllamokNo longer taking part
Trinity Health IHA Medical Group Hematology Oncology - CantonCanton, Egyesült ÁllamokTaking people
Trinity Health Medical Center - CantonCanton, Egyesült ÁllamokTaking people
Caro Cancer CenterCaro, Egyesült ÁllamokNo longer taking part
Saint Anthony Regional HospitalCarroll, Egyesült ÁllamokNo longer taking part
Carson Tahoe Regional Medical CenterCarson City, Egyesült ÁllamokNo longer taking part
Sandra L Maxwell Cancer CenterCedar City, Egyesült ÁllamokNo longer taking part
Rocky Mountain Cancer Centers - CentennialCentennial, Egyesült ÁllamokNo longer taking part
Providence Regional Cancer System-CentraliaCentralia, Egyesült ÁllamokNo longer taking part
UNC Lineberger Comprehensive Cancer CenterChapel Hill, Egyesült ÁllamokTaking people
Chelsea HospitalChelsea, Egyesült ÁllamokTaking people
Trinity Health IHA Medical Group Hematology Oncology - Chelsea HospitalChelsea, Egyesült ÁllamokTaking people
Cheyenne Regional Medical Center-WestCheyenne, Egyesült ÁllamokNo longer taking part
Northwestern UniversityChicago, Egyesült ÁllamokTaking people
Rush MD Anderson Cancer CenterChicago, Egyesült ÁllamokTaking people
University of Chicago Comprehensive Cancer CenterChicago, Egyesült ÁllamokTaking people
University of IllinoisChicago, Egyesült ÁllamokTaking people
University of Cincinnati Cancer Center-UC Medical CenterCincinnati, Egyesült ÁllamokTaking people
Siteman Cancer Center at Saint Peters HospitalCity of Saint Peters, Egyesült ÁllamokTaking people
Clackamas Radiation Oncology CenterClackamas, Egyesült ÁllamokNo longer taking part
Providence Cancer Institute Clackamas ClinicClackamas, Egyesült ÁllamokNo longer taking part
Hematology Oncology Consultants-ClarkstonClarkston, Egyesült ÁllamokNo longer taking part
Newland Medical Associates-ClarkstonClarkston, Egyesült ÁllamokNo longer taking part
Case Western Reserve UniversityCleveland, Egyesült ÁllamokTaking people
Cleveland Clinic FoundationCleveland, Egyesült ÁllamokTaking people
Prisma Health Cancer Institute - LaurensClinton, Egyesült ÁllamokNo longer taking part
Community Cancer InstituteClovis, Egyesült ÁllamokTaking people
University Oncology AssociatesClovis, Egyesült ÁllamokNo longer taking part
Billings Clinic-CodyCody, Egyesült ÁllamokNo longer taking part
Kootenai Health - Coeur d'AleneCoeur d'Alene, Egyesült ÁllamokTaking people
Prisma Health Richland HospitalColumbia, Egyesült ÁllamokTaking people
Ohio State University Comprehensive Cancer CenterColumbus, Egyesült ÁllamokTaking people
Mercy HospitalCoon Rapids, Egyesült ÁllamokNo longer taking part
Bay Area HospitalCoos Bay, Egyesült ÁllamokNo longer taking part
UC Irvine Health Cancer Center-NewportCosta Mesa, Egyesült ÁllamokTaking people
Siteman Cancer Center at West County HospitalCreve Coeur, Egyesült ÁllamokTaking people
Essentia Health - Deer River ClinicDeer River, Egyesült ÁllamokNo longer taking part
Cancer Center of Colorado at Sloan's LakeDenver, Egyesült ÁllamokNo longer taking part
Colorado Blood Cancer InstituteDenver, Egyesült ÁllamokNo longer taking part
National Jewish Health-Main CampusDenver, Egyesült ÁllamokNo longer taking part
Presbyterian - Saint Lukes Medical Center - Health OneDenver, Egyesült ÁllamokNo longer taking part
Rocky Mountain Cancer Centers-MidtownDenver, Egyesült ÁllamokNo longer taking part
Rocky Mountain Cancer Centers-RoseDenver, Egyesült ÁllamokNo longer taking part
Rose Medical CenterDenver, Egyesült ÁllamokNo longer taking part
Saint Joseph Hospital - Cancer Centers of ColoradoDenver, Egyesült ÁllamokNo longer taking part
The Women's Imaging CenterDenver, Egyesült ÁllamokNo longer taking part
Western Surgical CareDenver, Egyesült ÁllamokNo longer taking part
Blank Children's HospitalDes Moines, Egyesült ÁllamokNo longer taking part
Broadlawns Medical CenterDes Moines, Egyesült ÁllamokNo longer taking part
Iowa Lutheran HospitalDes Moines, Egyesült ÁllamokNo longer taking part
Iowa Methodist Medical CenterDes Moines, Egyesült ÁllamokNo longer taking part
UI Health Care Mission Cancer and Blood - Des Moines ClinicDes Moines, Egyesült ÁllamokNo longer taking part
Wayne State University/Karmanos Cancer InstituteDetroit, Egyesült ÁllamokTaking people
Henry Ford Health Saint John HospitalDetroit, Egyesült ÁllamokNo longer taking part
Essentia Health Saint Mary's - Detroit Lakes ClinicDetroit Lakes, Egyesült ÁllamokNo longer taking part
Kaiser Permanente DublinDublin, Egyesült ÁllamokTaking people
Essentia Health Cancer CenterDuluth, Egyesült ÁllamokTaking people
Essentia Health Saint Mary's Medical CenterDuluth, Egyesült ÁllamokNo longer taking part
Miller-Dwan HospitalDuluth, Egyesült ÁllamokNo longer taking part
Duke University Medical CenterDurham, Egyesült ÁllamokNo longer taking part
Prisma Health Cancer Institute - EasleyEasley, Egyesült ÁllamokTaking people
Henry Ford River District HospitalEast China Township, Egyesült ÁllamokNo longer taking part
Pocono Medical CenterEast Stroudsburg, Egyesült ÁllamokNo longer taking part
Fairview Southdale HospitalEdina, Egyesült ÁllamokNo longer taking part
Swedish Cancer Institute-EdmondsEdmonds, Egyesült ÁllamokTaking people
Walter Knox Memorial HospitalEmmett, Egyesült ÁllamokNo longer taking part
Mountain Blue Cancer Care Center - SwedishEnglewood, Egyesült ÁllamokNo longer taking part
Rocky Mountain Cancer Centers - SwedishEnglewood, Egyesült ÁllamokNo longer taking part
Swedish Medical CenterEnglewood, Egyesült ÁllamokNo longer taking part
The Melanoma and Skin Cancer InstituteEnglewood, Egyesült ÁllamokNo longer taking part
NorthShore University HealthSystem-Evanston HospitalEvanston, Egyesült ÁllamokTaking people
Providence Regional Cancer PartnershipEverett, Egyesült ÁllamokNo longer taking part
Fairbanks Memorial HospitalFairbanks, Egyesült ÁllamokNo longer taking part
Inova Schar Cancer InstituteFairfax, Egyesült ÁllamokNo longer taking part
Inova Fairfax HospitalFalls Church, Egyesült ÁllamokNo longer taking part
Essentia Health Cancer Center-South University ClinicFargo, Egyesült ÁllamokNo longer taking part
Weisberg Cancer Treatment CenterFarmington Hills, Egyesült ÁllamokTaking people
Lake Region Healthcare Corporation-Cancer CareFergus Falls, Egyesült ÁllamokNo longer taking part
Cancer Hematology Centers - FlintFlint, Egyesült ÁllamokTaking people
Genesys Hurley Cancer InstituteFlint, Egyesült ÁllamokTaking people
Hurley Medical CenterFlint, Egyesült ÁllamokTaking people
Genesee Hematology Oncology PCFlint, Egyesült ÁllamokNo longer taking part
UI Healthcare Mission Cancer and Blood - Fort DodgeFort Dodge, Egyesült ÁllamokNo longer taking part
Holy Cross HospitalFort Lauderdale, Egyesült ÁllamokNo longer taking part
Mercy Hospital Fort SmithFort Smith, Egyesült ÁllamokNo longer taking part
Essentia Health - FosstonFosston, Egyesült ÁllamokNo longer taking part
Kaiser Permanente-FremontFremont, Egyesült ÁllamokTaking people
Kaiser Permanente Fresno Orchard PlazaFresno, Egyesült ÁllamokTaking people
Kaiser Permanente-FresnoFresno, Egyesült ÁllamokTaking people
Fresno Cancer CenterFresno, Egyesült ÁllamokNo longer taking part
Unity HospitalFridley, Egyesült ÁllamokNo longer taking part
Saint Luke's Cancer Institute - FruitlandFruitland, Egyesült ÁllamokTaking people
Central Care Cancer Center - Garden CityGarden City, Egyesült ÁllamokNo longer taking part
NorthShore University HealthSystem-Glenbrook HospitalGlenview, Egyesült ÁllamokTaking people
National Jewish Health-Western Hematology OncologyGolden, Egyesült ÁllamokNo longer taking part
Saint Mary's Hospital and Regional Medical CenterGrand Junction, Egyesült ÁllamokNo longer taking part
Corewell Health Grand Rapids Hospitals - Butterworth HospitalGrand Rapids, Egyesült ÁllamokTaking people
Trinity Health Grand Rapids HospitalGrand Rapids, Egyesült ÁllamokTaking people
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's HospitalGrand Rapids, Egyesült ÁllamokNo longer taking part
Central Care Cancer Center - Great BendGreat Bend, Egyesült ÁllamokNo longer taking part
Benefis Sletten Cancer InstituteGreat Falls, Egyesült ÁllamokTaking people
Great Falls ClinicGreat Falls, Egyesült ÁllamokNo longer taking part
Banner North Colorado Medical CenterGreeley, Egyesült ÁllamokNo longer taking part
East Carolina UniversityGreenville, Egyesült ÁllamokTaking people
Prisma Health Cancer Institute - ButternutGreenville, Egyesült ÁllamokTaking people
Prisma Health Cancer Institute - EastsideGreenville, Egyesült ÁllamokTaking people
Prisma Health Cancer Institute - FarisGreenville, Egyesült ÁllamokTaking people
Prisma Health Greenville Memorial HospitalGreenville, Egyesült ÁllamokTaking people
Saint Francis Cancer CenterGreenville, Egyesült ÁllamokTaking people
Saint Francis HospitalGreenville, Egyesült ÁllamokTaking people
BI-LO Charities Children's Cancer CenterGreenville, Egyesült ÁllamokNo longer taking part
Prisma Health Cancer Institute - GreerGreer, Egyesült ÁllamokTaking people
Henry Ford Saint John Hospital - AcademicGrosse Pointe Woods, Egyesült ÁllamokNo longer taking part
Henry Ford Saint John Hospital - BreastGrosse Pointe Woods, Egyesült ÁllamokNo longer taking part
Henry Ford Saint John Hospital - Van ElslanderGrosse Pointe Woods, Egyesült ÁllamokNo longer taking part
Smilow Cancer Hospital Care Center at Saint FrancisHartford, Egyesült ÁllamokNo longer taking part
Essentia Health-Hayward ClinicHayward, Egyesült ÁllamokNo longer taking part
Lehigh Valley Hospital-HazletonHazleton, Egyesült ÁllamokNo longer taking part
Cancer and Blood Specialists-HendersonHenderson, Egyesült ÁllamokNo longer taking part
Comprehensive Cancer Centers of Nevada - HendersonHenderson, Egyesült ÁllamokNo longer taking part
Comprehensive Cancer Centers of Nevada-Horizon RidgeHenderson, Egyesült ÁllamokNo longer taking part
Comprehensive Cancer Centers of Nevada-Southeast HendersonHenderson, Egyesült ÁllamokNo longer taking part
Las Vegas Cancer Center-HendersonHenderson, Egyesült ÁllamokNo longer taking part
Las Vegas Urology - Green ValleyHenderson, Egyesült ÁllamokNo longer taking part
Las Vegas Urology - PebbleHenderson, Egyesült ÁllamokNo longer taking part
Oncology Las Vegas - HendersonHenderson, Egyesült ÁllamokNo longer taking part
Urology Specialists of Nevada - Green ValleyHenderson, Egyesült ÁllamokNo longer taking part
Essentia Health Hibbing ClinicHibbing, Egyesült ÁllamokNo longer taking part
NorthShore University HealthSystem-Highland Park HospitalHighland Park, Egyesült ÁllamokTaking people
Island Urology-HiloHilo, Egyesült ÁllamokNo longer taking part
Memorial Regional Hospital/Joe DiMaggio Children's HospitalHollywood, Egyesült ÁllamokTaking people
Loyola Medicine Homer GlenHomer Glen, Egyesült ÁllamokNo longer taking part
Kapiolani Medical Center for Women and ChildrenHonolulu, Egyesült ÁllamokTaking people
Straub Clinic and HospitalHonolulu, Egyesült ÁllamokTaking people
Hawaii Cancer Care Inc - Waterfront PlazaHonolulu, Egyesült ÁllamokNo longer taking part
Hawaii Cancer Care Inc-LilihaHonolulu, Egyesült ÁllamokNo longer taking part
Island UrologyHonolulu, Egyesült ÁllamokNo longer taking part
Kaiser Permanente Moanalua Medical CenterHonolulu, Egyesült ÁllamokNo longer taking part
Kuakini Medical CenterHonolulu, Egyesült ÁllamokNo longer taking part
Queen's Cancer Cenrer - POB IHonolulu, Egyesült ÁllamokNo longer taking part
Queen's Cancer Center - KuakiniHonolulu, Egyesült ÁllamokNo longer taking part
Queen's Medical CenterHonolulu, Egyesült ÁllamokNo longer taking part
The Cancer Center of Hawaii-LilihaHonolulu, Egyesült ÁllamokNo longer taking part
University of Hawaii Cancer CenterHonolulu, Egyesült ÁllamokNo longer taking part
Houston Methodist HospitalHouston, Egyesült ÁllamokTaking people
University of Iowa/Holden Comprehensive Cancer CenterIowa City, Egyesült ÁllamokTaking people
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory CareIrvine, Egyesült ÁllamokTaking people
Swedish Cancer Institute-IssaquahIssaquah, Egyesült ÁllamokNo longer taking part
Essentia Health - Jamestown ClinicJamestown, Egyesült ÁllamokNo longer taking part
Freeman Health SystemJoplin, Egyesült ÁllamokNo longer taking part
Mercy Hospital JoplinJoplin, Egyesült ÁllamokNo longer taking part
Beacon Kalamazoo Cancer CenterKalamazoo, Egyesült ÁllamokTaking people
Bronson Methodist HospitalKalamazoo, Egyesült ÁllamokTaking people
West Michigan Cancer CenterKalamazoo, Egyesült ÁllamokTaking people
Beacon KalamazooKalamazoo, Egyesült ÁllamokNo longer taking part
Logan Health Medical CenterKalispell, Egyesült ÁllamokTaking people
University of Kansas Cancer CenterKansas City, Egyesült ÁllamokTaking people
Kadlec Clinic Hematology and OncologyKennewick, Egyesült ÁllamokNo longer taking part
Kingman Regional Medical CenterKingman, Egyesült ÁllamokNo longer taking part
Providence Regional Cancer System-LaceyLacey, Egyesült ÁllamokNo longer taking part
Good Samaritan Hospital - Cancer Centers of ColoradoLafayette, Egyesült ÁllamokNo longer taking part
Northwestern Medicine Lake Forest HospitalLake Forest, Egyesült ÁllamokNo longer taking part
Northwell Health/Center for Advanced MedicineLake Success, Egyesült ÁllamokTaking people
Rocky Mountain Cancer Centers-LakewoodLakewood, Egyesült ÁllamokNo longer taking part
University of Michigan Health - Sparrow LansingLansing, Egyesült ÁllamokNo longer taking part
Alliance for Childhood Diseases/Cure 4 the Kids FoundationLas Vegas, Egyesült ÁllamokNo longer taking part
Ann M Wierman MD LTDLas Vegas, Egyesült ÁllamokNo longer taking part
Comprehensive Cancer Centers of NevadaLas Vegas, Egyesült ÁllamokNo longer taking part
Comprehensive Cancer Centers of Nevada - Central ValleyLas Vegas, Egyesült ÁllamokNo longer taking part
Comprehensive Cancer Centers of Nevada - NorthwestLas Vegas, Egyesült ÁllamokNo longer taking part
Comprehensive Cancer Centers of Nevada - Town CenterLas Vegas, Egyesült ÁllamokNo longer taking part
Comprehensive Cancer Centers of Nevada-SummerlinLas Vegas, Egyesült ÁllamokNo longer taking part
Desert West SurgeryLas Vegas, Egyesült ÁllamokNo longer taking part
Hope Cancer Care of NevadaLas Vegas, Egyesült ÁllamokNo longer taking part
Las Vegas Cancer Center-Medical CenterLas Vegas, Egyesült ÁllamokNo longer taking part
Las Vegas Prostate Cancer CenterLas Vegas, Egyesült ÁllamokNo longer taking part
Las Vegas Urology - Cathedral RockLas Vegas, Egyesült ÁllamokNo longer taking part
Las Vegas Urology - PecosLas Vegas, Egyesült ÁllamokNo longer taking part
Las Vegas Urology - Smoke RanchLas Vegas, Egyesült ÁllamokNo longer taking part
Las Vegas Urology - SunsetLas Vegas, Egyesült ÁllamokNo longer taking part
Oncology Las Vegas - TenayaLas Vegas, Egyesült ÁllamokNo longer taking part
OptumCare Cancer Care at CharlestonLas Vegas, Egyesült ÁllamokNo longer taking part
OptumCare Cancer Care at Fort ApacheLas Vegas, Egyesült ÁllamokNo longer taking part
OptumCare Cancer Care at MountainViewLas Vegas, Egyesült ÁllamokNo longer taking part
Radiation Oncology Centers of Nevada CentralLas Vegas, Egyesült ÁllamokNo longer taking part
Radiation Oncology Centers of Nevada SoutheastLas Vegas, Egyesült ÁllamokNo longer taking part
Summerlin Hospital Medical CenterLas Vegas, Egyesült ÁllamokNo longer taking part
Sunrise Hospital and Medical CenterLas Vegas, Egyesült ÁllamokNo longer taking part
University Cancer CenterLas Vegas, Egyesült ÁllamokNo longer taking part
University Medical Center of Southern NevadaLas Vegas, Egyesült ÁllamokNo longer taking part
Urology Specialists of Nevada - CentralLas Vegas, Egyesült ÁllamokNo longer taking part
Urology Specialists of Nevada - NorthwestLas Vegas, Egyesült ÁllamokNo longer taking part
Urology Specialists of Nevada - SouthwestLas Vegas, Egyesült ÁllamokNo longer taking part
Lawrence Memorial HospitalLawrence, Egyesült ÁllamokNo longer taking part
University of Kentucky/Markey Cancer CenterLexington, Egyesült ÁllamokTaking people
Wilcox Memorial Hospital and Kauai Medical ClinicLihue, Egyesült ÁllamokNo longer taking part
Rush MD Anderson Cancer Center at Rush LisleLisle, Egyesült ÁllamokNo longer taking part
Rocky Mountain Cancer Centers-LittletonLittleton, Egyesült ÁllamokNo longer taking part
Trinity Health Saint Mary Mercy Livonia HospitalLivonia, Egyesült ÁllamokTaking people
Hope Cancer ClinicLivonia, Egyesült ÁllamokNo longer taking part
Logan Regional HospitalLogan, Egyesült ÁllamokNo longer taking part
Rocky Mountain Cancer Centers-Sky RidgeLone Tree, Egyesült ÁllamokNo longer taking part
Sky Ridge Medical CenterLone Tree, Egyesült ÁllamokNo longer taking part
PeaceHealth Saint John Medical CenterLongview, Egyesült ÁllamokNo longer taking part
Banner North Colorado Medical Center - Loveland CampusLoveland, Egyesült ÁllamokNo longer taking part
Covenant Medical Center-LakesideLubbock, Egyesült ÁllamokNo longer taking part
Henry Ford Saint John Hospital - Macomb MedicalMacomb, Egyesült ÁllamokTaking people
Henry Ford Warren Hospital - Breast MacombMacomb, Egyesült ÁllamokNo longer taking part
University of Wisconsin Carbone Cancer Center - Eastpark Medical CenterMadison, Egyesült ÁllamokTaking people
University of Wisconsin Carbone Cancer Center - University HospitalMadison, Egyesült ÁllamokTaking people
North Shore University HospitalManhasset, Egyesült ÁllamokTaking people
Fairview Clinics and Surgery Center Maple GroveMaple Grove, Egyesült ÁllamokNo longer taking part
Minnesota Oncology Hematology PA-MaplewoodMaplewood, Egyesült ÁllamokNo longer taking part
Saint John's Hospital - HealtheastMaplewood, Egyesült ÁllamokNo longer taking part
Saint Mary's Oncology/Hematology Associates of MarletteMarlette, Egyesült ÁllamokNo longer taking part
Marshfield Medical Center-MarshfieldMarshfield, Egyesült ÁllamokTaking people
Loyola University Medical CenterMaywood, Egyesült ÁllamokTaking people
Marjorie Weinberg Cancer Center at Loyola-GottliebMelrose Park, Egyesült ÁllamokNo longer taking part
Saint Luke's Cancer Institute - MeridianMeridian, Egyesült ÁllamokTaking people
Idaho Urologic Institute-MeridianMeridian, Egyesült ÁllamokNo longer taking part
Miami Cancer InstituteMiami, Egyesült ÁllamokNo longer taking part
Medical College of WisconsinMilwaukee, Egyesült ÁllamokTaking people
Abbott-Northwestern HospitalMinneapolis, Egyesült ÁllamokTaking people
Health Partners IncMinneapolis, Egyesült ÁllamokNo longer taking part
Hennepin County Medical CenterMinneapolis, Egyesült ÁllamokNo longer taking part
Community Medical CenterMissoula, Egyesült ÁllamokTaking people
Saint Patrick Hospital - Community HospitalMissoula, Egyesült ÁllamokNo longer taking part
Kaiser Permanente- Modesto MOB IIModesto, Egyesült ÁllamokTaking people
Kaiser Permanente-ModestoModesto, Egyesült ÁllamokTaking people
Monticello Cancer CenterMonticello, Egyesült ÁllamokNo longer taking part
SSM Health Good SamaritanMount Vernon, Egyesült ÁllamokNo longer taking part
Intermountain Medical CenterMurray, Egyesült ÁllamokNo longer taking part
Trinity Health Muskegon HospitalMuskegon, Egyesült ÁllamokNo longer taking part
Saint Alphonsus Cancer Care Center-NampaNampa, Egyesült ÁllamokTaking people
Saint Luke's Cancer Institute - NampaNampa, Egyesült ÁllamokTaking people
Yale UniversityNew Haven, Egyesült ÁllamokTaking people
Smilow Cancer Center/Yale-New Haven HospitalNew Haven, Egyesült ÁllamokNo longer taking part
Long Island Jewish Medical CenterNew Hyde Park, Egyesült ÁllamokTaking people
UC Comprehensive Cancer Center at Silver CrossNew Lenox, Egyesült ÁllamokTaking people
Ochsner Medical Center JeffersonNew Orleans, Egyesült ÁllamokNo longer taking part
Cancer Center of Western WisconsinNew Richmond, Egyesült ÁllamokNo longer taking part
New Ulm Medical CenterNew Ulm, Egyesült ÁllamokNo longer taking part
Mount Sinai HospitalNew York, Egyesült ÁllamokTaking people
NYP/Weill Cornell Medical CenterNew York, Egyesült ÁllamokTaking people
Providence Newberg Medical CenterNewberg, Egyesült ÁllamokTaking people
Corewell Health Lakeland Hospitals - Niles HospitalNiles, Egyesült ÁllamokTaking people
Cancer and Hematology Centers of Western Michigan - Norton ShoresNorton Shores, Egyesült ÁllamokNo longer taking part
Kaiser Permanente-OaklandOakland, Egyesült ÁllamokTaking people
Kaiser Permanente Oakland-BroadwayOakland, Egyesült ÁllamokNo longer taking part
McKay-Dee Hospital CenterOgden, Egyesült ÁllamokNo longer taking part
University of Oklahoma Health Sciences CenterOklahoma City, Egyesült ÁllamokTaking people
Mercy Hospital Oklahoma CityOklahoma City, Egyesült ÁllamokNo longer taking part
Nebraska Medicine-Village PointeOmaha, Egyesült ÁllamokTaking people
University of Nebraska Medical CenterOmaha, Egyesült ÁllamokTaking people
Saint Alphonsus Cancer Care Center-OntarioOntario, Egyesült ÁllamokTaking people
UC Irvine Health- Chao Family Comprehensive Cancer CenterOrange, Egyesült ÁllamokTaking people
University of Chicago Medicine-Orland ParkOrland Park, Egyesült ÁllamokTaking people
Orlando Health Cancer InstituteOrlando, Egyesült ÁllamokTaking people
Hope Cancer Care of Nevada-PahrumpPahrump, Egyesült ÁllamokNo longer taking part
Stanford Cancer Institute Palo AltoPalo Alto, Egyesült ÁllamokTaking people
Essentia Health - Park RapidsPark Rapids, Egyesült ÁllamokNo longer taking part
Memorial Hospital WestPembroke Pines, Egyesült ÁllamokNo longer taking part
Thomas Jefferson University HospitalPhiladelphia, Egyesült ÁllamokTaking people
University of Pennsylvania/Abramson Cancer CenterPhiladelphia, Egyesült ÁllamokTaking people
Mayo Clinic Hospital in ArizonaPhoenix, Egyesült ÁllamokNo longer taking part
UPMC Hillman Cancer CenterPittsburgh, Egyesült ÁllamokNo longer taking part
Trinity Health Saint Joseph Mercy Oakland HospitalPontiac, Egyesült ÁllamokTaking people
Hope Cancer CenterPontiac, Egyesült ÁllamokNo longer taking part
Michigan Healthcare Professionals PontiacPontiac, Egyesült ÁllamokNo longer taking part
Trinity Health IHA Medical Group-Alice Gustafson CenterPontiac, Egyesült ÁllamokNo longer taking part
Jefferson HealthcarePort Townsend, Egyesült ÁllamokNo longer taking part
Oregon Health and Science UniversityPortland, Egyesült ÁllamokTaking people
Providence Portland Medical CenterPortland, Egyesült ÁllamokTaking people
Providence Saint Vincent Medical CenterPortland, Egyesült ÁllamokTaking people
Kootenai Clinic Cancer Services - Post FallsPost Falls, Egyesült ÁllamokTaking people
Fairview Northland Medical CenterPrinceton, Egyesült ÁllamokNo longer taking part
Rhode Island HospitalProvidence, Egyesült ÁllamokTaking people
Miriam HospitalProvidence, Egyesült ÁllamokNo longer taking part
Utah Valley Regional Medical CenterProvo, Egyesült ÁllamokNo longer taking part
Kaiser Permanente-Rancho Cordova Cancer CenterRancho Cordova, Egyesült ÁllamokNo longer taking part
Saint Charles Health System-RedmondRedmond, Egyesült ÁllamokNo longer taking part
Kaiser Permanente- Marshall Medical OfficesRedwood City, Egyesült ÁllamokNo longer taking part
Kaiser Permanente-Redwood CityRedwood City, Egyesült ÁllamokNo longer taking part
Corewell Health Reed City HospitalReed City, Egyesült ÁllamokTaking people
Radiation Oncology AssociatesReno, Egyesült ÁllamokNo longer taking part
Renown Regional Medical CenterReno, Egyesült ÁllamokNo longer taking part
Saint Mary's Regional Medical CenterReno, Egyesült ÁllamokNo longer taking part
Valley Medical CenterRenton, Egyesült ÁllamokNo longer taking part
Kaiser Permanente-RichmondRichmond, Egyesült ÁllamokTaking people
VCU Massey Comprehensive Cancer CenterRichmond, Egyesült ÁllamokTaking people
Riverton HospitalRiverton, Egyesült ÁllamokNo longer taking part
North Memorial Medical Health CenterRobbinsdale, Egyesült ÁllamokNo longer taking part
Mayo Clinic in RochesterRochester, Egyesült ÁllamokTaking people
University of RochesterRochester, Egyesült ÁllamokTaking people
Henry Ford Rochester HospitalRochester Hills, Egyesült ÁllamokNo longer taking part
Rohnert Park Cancer CenterRohnert Park, Egyesült ÁllamokNo longer taking part
Mercy Clinic-Rolla-Cancer and HematologyRolla, Egyesült ÁllamokNo longer taking part
Phelps Health Delbert Day Cancer InstituteRolla, Egyesült ÁllamokNo longer taking part
Kaiser Permanente-RosevilleRoseville, Egyesült ÁllamokTaking people
The Permanente Medical Group-Roseville Radiation OncologyRoseville, Egyesült ÁllamokNo longer taking part
Kaiser Permanente Downtown CommonsSacramento, Egyesült ÁllamokTaking people
Kaiser Permanente-South SacramentoSacramento, Egyesült ÁllamokTaking people
University of California Davis Comprehensive Cancer CenterSacramento, Egyesült ÁllamokTaking people
Kaiser Permanente Sacramento Medical CenterSacramento, Egyesült ÁllamokNo longer taking part
South Sacramento Cancer CenterSacramento, Egyesült ÁllamokNo longer taking part
MyMichigan Medical Center SaginawSaginaw, Egyesült ÁllamokNo longer taking part
Oncology Hematology Associates of Saginaw Valley PCSaginaw, Egyesült ÁllamokNo longer taking part
Corewell Health Lakeland Hospitals - Marie Yeager Cancer CenterSaint Joseph, Egyesült ÁllamokTaking people
Corewell Health Lakeland Hospitals - Saint Joseph HospitalSaint Joseph, Egyesült ÁllamokNo longer taking part
Heartland Regional Medical CenterSaint Joseph, Egyesült ÁllamokNo longer taking part
Park Nicollet Clinic - Saint Louis ParkSaint Louis Park, Egyesült ÁllamokNo longer taking part
Regions HospitalSaint Paul, Egyesült ÁllamokNo longer taking part
United HospitalSaint Paul, Egyesült ÁllamokNo longer taking part
Huntsman Cancer Institute/University of UtahSalt Lake City, Egyesült ÁllamokTaking people
LDS HospitalSalt Lake City, Egyesült ÁllamokNo longer taking part
Utah Cancer Specialists-Salt Lake CitySalt Lake City, Egyesült ÁllamokNo longer taking part
Kaiser Permanente-San FranciscoSan Francisco, Egyesült ÁllamokTaking people
Kaiser Permanente-Santa Teresa-San JoseSan Jose, Egyesült ÁllamokTaking people
Kaiser Permanente San LeandroSan Leandro, Egyesült ÁllamokTaking people
Kaiser San Rafael-GallinasSan Rafael, Egyesült ÁllamokTaking people
Kaiser Permanente-San RafaelSan Rafael, Egyesült ÁllamokNo longer taking part
Kootenai Clinic Cancer Services - SandpointSandpoint, Egyesült ÁllamokTaking people
Essentia Health SandstoneSandstone, Egyesült ÁllamokNo longer taking part
Kaiser Permanente Medical Center - Santa ClaraSanta Clara, Egyesült ÁllamokTaking people
Kaiser Permanente-Santa RosaSanta Rosa, Egyesült ÁllamokTaking people
Mayo Clinic in ArizonaScottsdale, Egyesült ÁllamokNo longer taking part
Swedish Medical Center-First HillSeattle, Egyesült ÁllamokTaking people
Kaiser Permanente WashingtonSeattle, Egyesült ÁllamokNo longer taking part
Pacific Gynecology SpecialistsSeattle, Egyesült ÁllamokNo longer taking part
Swedish Medical Center-Ballard CampusSeattle, Egyesült ÁllamokNo longer taking part
Swedish Medical Center-Cherry HillSeattle, Egyesült ÁllamokNo longer taking part
PeaceHealth United General Medical CenterSedro-Woolley, Egyesült ÁllamokNo longer taking part
Prisma Health Cancer Institute - SenecaSeneca, Egyesült ÁllamokTaking people
Saint Francis Regional Medical CenterShakopee, Egyesült ÁllamokNo longer taking part
Providence Regional Cancer System-SheltonShelton, Egyesült ÁllamokNo longer taking part
Welch Cancer CenterSheridan, Egyesült ÁllamokNo longer taking part
Kaiser Permanente-South San FranciscoSouth San Francisco, Egyesült ÁllamokTaking people
Kaiser Permanente Cancer Treatment CenterSouth San Francisco, Egyesült ÁllamokNo longer taking part
Essentia Health-Spooner ClinicSpooner, Egyesült ÁllamokNo longer taking part
CoxHealth South HospitalSpringfield, Egyesült ÁllamokNo longer taking part
Mercy Hospital SpringfieldSpringfield, Egyesült ÁllamokNo longer taking part
Mercy Hospital Saint LouisSt Louis, Egyesült ÁllamokTaking people
Mercy Hospital SouthSt Louis, Egyesült ÁllamokTaking people
Siteman Cancer Center-South CountySt Louis, Egyesült ÁllamokTaking people
Washington University School of MedicineSt Louis, Egyesült ÁllamokTaking people
Mercy Infusion Center - ChippewaSt Louis, Egyesült ÁllamokNo longer taking part
Saint George Regional Medical CenterSt. George, Egyesült ÁllamokNo longer taking part
Bhadresh Nayak MD PC-Sterling HeightsSterling Heights, Egyesült ÁllamokNo longer taking part
Lakeview HospitalStillwater, Egyesült ÁllamokNo longer taking part
Kaiser Permanente-StocktonStockton, Egyesült ÁllamokTaking people
Stony Brook University Medical CenterStony Brook, Egyesült ÁllamokNo longer taking part
Essentia Health Saint Mary's Hospital - SuperiorSuperior, Egyesült ÁllamokNo longer taking part
State University of New York Upstate Medical UniversitySyracuse, Egyesült ÁllamokNo longer taking part
MyMichigan Medical Center TawasTawas City, Egyesült ÁllamokNo longer taking part
National Jewish Health-Northern Hematology OncologyThornton, Egyesült ÁllamokNo longer taking part
Rocky Mountain Cancer Centers-ThorntonThornton, Egyesült ÁllamokNo longer taking part
Munson Medical CenterTraverse City, Egyesült ÁllamokTaking people
Saint Luke's Cancer Institute - Twin FallsTwin Falls, Egyesült ÁllamokTaking people
Kaiser Permanente Medical Center-VacavilleVacaville, Egyesült ÁllamokTaking people
Kaiser Permanente-VallejoVallejo, Egyesült ÁllamokTaking people
PeaceHealth Southwest Medical CenterVancouver, Egyesült ÁllamokNo longer taking part
Upstate Cancer Center at VeronaVerona, Egyesült ÁllamokNo longer taking part
Essentia Health Virginia ClinicVirginia, Egyesült ÁllamokNo longer taking part
Ridgeview Medical CenterWaconia, Egyesült ÁllamokNo longer taking part
Providence Saint Mary Regional Cancer CenterWalla Walla, Egyesült ÁllamokNo longer taking part
Kaiser Permanente-Walnut CreekWalnut Creek, Egyesült ÁllamokTaking people
Advanced Breast Care Center PLLCWarren, Egyesült ÁllamokNo longer taking part
Henry Ford Health Warren HospitalWarren, Egyesült ÁllamokNo longer taking part
Henry Ford Madison Heights Hospital - BreastWarren, Egyesült ÁllamokNo longer taking part
Henry Ford Warren Hospital - GLCMSWarren, Egyesült ÁllamokNo longer taking part
Macomb Hematology Oncology PCWarren, Egyesült ÁllamokNo longer taking part
Mercy Hospital WashingtonWashington, Egyesült ÁllamokNo longer taking part
Saint Mary's Oncology/Hematology Associates of West BranchWest Branch, Egyesült ÁllamokNo longer taking part
University of Cincinnati Cancer Center-West ChesterWest Chester, Egyesült ÁllamokTaking people
Methodist West HospitalWest Des Moines, Egyesült ÁllamokNo longer taking part
University of Kansas Hospital-Westwood Cancer CenterWestwood, Egyesült ÁllamokTaking people
Intermountain Health Lutheran HospitalWheat Ridge, Egyesült ÁllamokNo longer taking part
Cancer Center of Kansas - WichitaWichita, Egyesült ÁllamokTaking people
Ascension Via Christi Hospitals WichitaWichita, Egyesült ÁllamokNo longer taking part
Cancer Center of Kansas-Wichita Medical Arts TowerWichita, Egyesült ÁllamokNo longer taking part
Wesley Medical CenterWichita, Egyesült ÁllamokNo longer taking part
Rice Memorial HospitalWillmar, Egyesült ÁllamokNo longer taking part
Wake Forest University Health SciencesWinston-Salem, Egyesült ÁllamokTaking people
Minnesota Oncology Hematology PA-WoodburyWoodbury, Egyesült ÁllamokNo longer taking part
University of Michigan Health - WestWyoming, Egyesült ÁllamokTaking people
Fairview Lakes Medical CenterWyoming, Egyesült ÁllamokNo longer taking part
North Star Lodge Cancer Center at Yakima Valley Memorial HospitalYakima, Egyesült ÁllamokNo longer taking part
Providence Regional Cancer System-YelmYelm, Egyesült ÁllamokNo longer taking part
Huron Gastroenterology PCYpsilanti, Egyesült ÁllamokTaking people
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor CampusYpsilanti, Egyesült ÁllamokTaking people

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Trial details

Who runs it: Alliance for Clinical Trials in Oncology
Trial code: NCT03150693
Record updated: 2026. november 3.
Original description: This phase III trial studies the side effects of inotuzumab ozogamicin and how well it works when given with frontline chemotherapy in treating patients with newly diagnosed B acute lymphoblastic leukemia. Inotuzumab ozogamicin is a monoclonal antibody, called inotuzumab, linked to a chemotherapy drug called ozogamicin. Inotuzumab is a form of targeted therapy because it attaches to specific molecules (receptors) on the surface of cancer cells, known as CD22 receptors, and delivers ozogamicin to kill them. Chemotherapy drugs, such as [intervention], work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving inotuzumab ozogamicin with chemotherapy may work better in treating young adults with B acute lymphoblastic leukemia.Read full original descriptionShow less
A Phase III Trial to Evaluate the Efficacy of the Addition of Inotuzumab Ozogamicin (a Conjugated Anti-CD22 Monoclonal Antibody) to Frontline Therapy in Young Adults (Ages 18-39 Years) With Newly Diagnosed Precursor B-Cell ALL
This phase III trial studies the side effects of inotuzumab ozogamicin and how well it works when given with frontline chemotherapy in treating patients with newly diagnosed B acute lymphoblastic leukemia. Inotuzumab ozogamicin is a monoclonal antibody, called inotuzumab, linked to a chemotherapy drug called ozogamicin. Inotuzumab is a form of targeted therapy because it attaches to specific molecules (receptors) on the surface of cancer cells, known as CD22 receptors, and delivers ozogamicin to kill them. Chemotherapy drugs, such as [intervention], work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving inotuzumab ozogamicin with chemotherapy may work better in treating young adults with B acute lymphoblastic leukemia.
Inclusion: REGISTRATION ELIGIBILITY CRITERIA (STEP 1); Newly diagnosed patients with CD-22 positive B-cell acute lymphoblastic leukemia (WHO criteria) are eligible. Patients with Burkitt type ALL are NOT eligible; REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Single-dose intrathecal cytarabine is allowed prior to registration or prior to initiation of systematic therapy for patient convenience; this is usually done at the time of the diagnostic bone marrow or venous line placement to avoid a second lumbar puncture; systemic chemotherapy must begin within 72 hours of this intrathecal therapy; REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Age >= 18 years and < 40 years; REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Eastern Cooperative Oncology Group (ECOG) performance status 0-2; REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Aspartate aminotransferase (AST), alanine aminotransferase (ALT) =< 3 x upper limit of normal (ULN), unless suspected leukemic involvement of the liver; REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Direct bilirubin =< 3 x upper limit of normal (ULN), unless suspected leukemic involvement of the liver; REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Calculated (calc.) creatinine clearance >= 50 mL/min by Cockcroft-Gault; RANDOMIZATION ELIGIBILITY CRITERIA (STEP 2) CONFIRMATION OF TOLERABILITY AND PHASE III ONLY): Completion of remission induction therapy; RANDOMIZATION ELIGIBILITY CRITERIA (STEP 2) CONFIRMATION OF TOLERABILITY AND PHASE III ONLY):Patients with M2 marrow or better are eligible; patients with M3 or M4 marrow (greater than 25% lymphoblasts) will not be eligible to be randomized; Rating: M0, M1; Blast Cells (%): 0-5.0; Rating: M2; Blast Cells (%): 5.1-25.0; Rating: M3; Blast Cells (%): > 25-50; Rating: M4; Blast Cells (%): > 50.0; The term "blast cell" includes any cell that cannot be classified as a more mature normal element, and includes "leukemic cells," pathologic lymphocytes, and stem cells; RANDOMIZATION ELIGIBILITY CRITERIA (STEP 2) (CONFIRMATION OF TOLERABILITY AND PHASE III ONLY): Absolute neutrophil count (ANC) >= 750/mm\^3; RANDOMIZATION ELIGIBILITY CRITERIA (STEP 2) (CONFIRMATION OF TOLERABILITY AND PHASE III ONLY): Platelet count >= 75,000/mm\^3; RANDOMIZATION ELIGIBILITY CRITERIA (STEP 2) (CONFIRMATION OF TOLERABILITY AND PHASE III ONLY): Total bilirubin =< 1.5 x upper limit of normal (ULN), except for patients with known Gilbert's syndrome; RANDOMIZATION ELIGIBILITY CRITERIA (STEP 2) (CONFIRMATION OF TOLERABILITY AND PHASE III ONLY): Aspartate aminotransferase (AST) =< 8 x upper limit of normal (ULN).
Exclusion: REGISTRATION ELIGIBILITY CRITERIA (STEP 1): No prior therapy for ALL except for limited treatment (=< 7 days) with corticosteroids or hydroxyurea and a single dose of intrathecal cytarabine; however, patients who are being treated with chronic steroids for other reasons (for example, to treat asthma, autoimmune disorders, lupus, etc.) are eligible; REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Patients with down syndrome are excluded from this study due to the likelihood of excessive toxicity resulting; these patients should be treated in consultation with a pediatric oncologist; REGISTRATION ELIGIBILITY CRITERIA (STEP 1): No prior therapy for acute leukemia except emergency therapy (corticosteroids or hydroxyurea) for blast cell crisis, superior vena cava syndrome, or renal failure due to leukemic infiltration of the kidneys; when indicated, leukapheresis or exchange transfusion is recommended to reduce the WBC; REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Not pregnant and not nursing, because this study involves agents that have known genotoxic, mutagenic and teratogenic effects; therefore, for women of childbearing potential only, a negative urine or serum pregnancy test done =< 8 days prior to registration is required; REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Patients who have BCR-ABL fusion transcript determined by fluorescence in situ hybridization (FISH) or real time-polymerase chain reaction (RT-PCR) or t(9;22)(q34;q11) by cytogenetics are not eligible and should be considered for enrollment on studies that incorporate imatinib during induction; please note: patients must also be assessed for CD20 positivity and other markers; positivity for CD22 and CD20 is defined as baseline expression of the CD22 or CD20 antigen in more than 20% of leukemic cells using local multiparameter flow-cytometric immunophenotyping with the use of CD45 expression as a marker to gate the ALL blast population, according to recommendations from the European LeukemiaNet.
ClinicalTrials.gov NCT03150693