Multinational Clinical Study Comparing Isatuximab, Carfilzomib And Dexamethasone To Carfilzomib And Dexamethasone In Relapse And/Or Refractory Multiple Myeloma Patients

Korábbi kezelés

• Participants previously pretreated with carfilzomib, who never achieved at least one minor response during previous therapies and/or last previous therapy completed within 14 last days.

Más betegség

• Participants with previous cancer unless disease free for more than 5 years or in situ cancer curatively treated.
• Participants with known acquired immunodeficiency syndrome related illness or human immunodeficiency virus requiring antiretroviral treatment, or hepatitis A, B, or C active infection.

Laborértékek

• Participants with serum free light chain (FLC) measurable disease only.
• Participants with myocardial infarction, severe/unstable angina pectoris, coronary/peripheral artery bypass graft, New York Heart Association class III or IV congestive heart failure, superior or equal to grade 3 arrhythmias, stroke or transient ischemic attack within last 6 months, and/or left ventricular ejection fraction lower than 40%.

Életkor

• Participants less than 18 years old, participants with Eastern Cooperative Oncology Group performance status more than 2.

Egyéb

• Participants with inadequate biological tests.
• Women of childbearing potential or male participant with women of childbearing potential who do not agree to use highly effective method of birth control.
  • The above information is not intended to contain all considerations relevant to a participant's potential participation in a clinical trial.

• Participants with MM previously treated with prior 1 to 3 lines and with measurable serum M-protein (\>= 0.5 gram/deciliter) and/or urine M-protein (\>= 200 milligram/24 hours).