NCT03361020Fut, nem toboroz
Obstructive Sleep Apnea in Survivors of Hodgkin Lymphoma Treated With Thoracic Radiation
Forrás: ClinicalTrials.gov · Utoljára frissítve: 2026. jún. 17.
Rövid összefoglaló (regiszter, angolul)
While thoracic radiation therapy (TRT) has been a primary component in successful treatment of Hodgkin lymphoma, exposure to this treatment has been associated with significant cardiovascular, cerebrovascular, and pulmonary morbidity in long-term survivors. Survivors of Hodgkin lymphoma (HL) are also at risk for fatigue and excessive daytime sleepiness. Insufficient sleep is recognized as an important public health concern, and is associated with cardiovascular disease, diabetes, obesity, neurocognitive problems, and reduced quality of life and productivity. Survivors of HL, who are already at risk for cardiac and neurologic morbidity due to their treatment exposures, could face catastrophic cardiovascular and cerebrovascular events with the added risk associated with obstructive sleep apnea (OSA). The investigators propose to examine indices of sleep quality using polysomnography, and associated neurocognitive performance, brain MRI, and structure and strength of neck muscles in 220 long-term adult survivors of Hodgkin lymphoma treated with thoracic radiation. OBJECTIVES: 1. To estimate the prevalence of OSA in adult survivors of HL treated with thoracic radiation, and compare the frequency to community controls matched on age, gender, race and body mass index. 2. To identify specific therapeutic factors associated with OSA in adult survivors of HL treated with thoracic radiation. 3. To identify biomarkers of OSA in adult survivors of HL treated with thoracic radiation. 4. To examine associations between OSA and cardiac morbidity and brain integrity in the adult survivors of HL treated with thoracic radiation.
- Állapot (regiszter)
- Fut, nem toboroz
- Vizsgálattípus
- Megfigyeléses
- Résztvevők száma
- 434 (tényleges)
- Első benyújtás
- 2017. nov. 28.
- Kezdés
- 2018. jan. 23.
- Elsődleges befejezés
- 2023. júl. 31.
- Fő szponzor
- St. Jude Children's Research Hospital
- Betegségek
- Hodgkin-limfóma
- NCT-szám
- NCT03361020
Mit vállalsz
- Vizsgálat típusa: Megfigyeléses
- Bevont résztvevők: 434
- 2018. jan. 23. és az elsődleges befejezés (2023. júl. 31.) között
- 1 helyszín, 1 országban
- Vizitek és vizsgálatok: kérdezd a vizsgálat csapatát, a regiszter nem sorolja fel őket
A(z) ClinicalTrials.gov regisztermezőiből összeállítva. A vizsgálat felépítését írja le.
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Más betegség
- History of cranial or total-body radiation therapy
- History of intrathecal Methotrexate, high-dose Methotrexate, or high-dose Cytarabine.
- History of head injury or diagnosis of a genetic disorder associated with neurocognitive impairment
- History of a neurodevelopmental disorder or birth complication associated with neurocognitive impairment
- History of congenital heart disease reported in the literature to be associated with neurocognitive status as determined by the PIs
- History of cranial, total-body or thoracic radiation therapy
- History of intrathecal Methotrexate, high-dose Methotrexate, or high-dose Cytarabine.
- History of head injury or diagnosis of a genetic disorder associated with neurocognitive impairment
- History of a neurodevelopmental disorder or birth complication associated with neurocognitive impairment
- History of congenital heart disease reported in the literature to be associated with neurocognitive status as determined by the PIs
- History of cancer
Egyéb
- Currently pregnant
- Secondary central nervous system (CNS) neoplasm
- COMPARISON GROUP (CONTROL) ELIGIBILITY CRITERIA
- Currently pregnant
- 1st degree relative of a survivor included in the current study.
Kiket keres a vizsgálat
- Current participant in the SJLIFE clinical trial ongoing at St. Jude Children's Research Hospital (SJCRH) and was treated with thoracic radiation for Hodgkin lymphoma
- Currently ≥ 18 years of age
- ≥ 5 years from original diagnosis
- Research participant is a sibling, parent, relative or friend of a current or former St. Jude patient
- Research participant must be at least 18 years of age at the time of the scheduled evaluation
A regiszterben nem jelölt feltételek
- HODGKIN LYMPHOMA SURVIVOR ELIGIBILITY CRITERIA
Életkor a regiszterben: 18 év – - · Nem: nők és férfiak · Egészséges önkénteseket nem fogad
Helyszínek (1)
Helyszínek a regiszter sorrendjében. Ha a profilodba mented a városodat, távolság szerint rendeződnek.
| Helyszín | Város | Ország | Helyszín állapota |
|---|---|---|---|
| St. Jude Children's Research Hospital | Memphis | Egyesült Államok | Ismeretlen állapot |
Ez az oldal tájékoztatás, nem orvosi tanács. Bármely vizsgálatról az orvosoddal beszélj.