Stereotactic Body Radiation Therapy for Spinal Metastases in Favorite Tumors

Korábbi kezelés

• The metastatic area previously received radiation;

Más betegség

• Uncontrolled co-morbid illnesses;
  • 9.refused to signed informed consent;

Egyéb

• There were significant changes in the shape of the vertebral body (the height of the vertebral body was compressed≥ 50%) or the vertebral body was unchanged but the volume of the dissolving bone was≥ 50% and could lead to serious bone adverse events;
• There were >3 consecutive vertebral bodies involved;
• Spinal cord compression has occurred;
• The gap between tumor and spinal cord was less than 3mm;
• Pregnant and Nursing women;

• WHO scores 0-2;
• The primary lesion was confirmed by pathology or cytology;
• The metastatic lesions were diagnosed by imaging(CT,MRI,PET-CT,ECT),or the lesions were confirmed by biopsy;
• The metastatic lesion was limited in 3 consecutive vertebral bodies;
• The baseline pain score was ≥5(NRPS) and the use of analgesic drugs was recorded;
• The enhanced MRI scan of involved vertebral bodies was required in the 2 weeks before radiotherapy;
  • Adequate bone marrow, hepatic and renal function as assessed by the following laboratory requirements conducted within 7 days of starting study treatment:
• Leukocytes ≥ 3.0 x109/ L;
• Absolute neutrophil count (ANC) ≥ 1.5 x109/ L;
• Platelet count ≥ 100 x109/ L;
• Hemoglobin (Hb) ≥ 9g/ dL;
• Total bilirubin ≤1.5 x the upper limit of normal (ULN);
• Alanine aminotransferase (ALT) ≤ 3 x ULN;
• Aspartate aminotransferase (AST) ≤ 3 x ULN;
• Serum creatinine ≤ 1.5 x the ULN;
• Signed informed consent;