UV1 Vaccine With Pembrolizumab for Patients With Unresectable or Metastatic Melanoma

Korábbi kezelés

• Prior systemic treatment for unresectable or metastatic melanoma. Exception: Prior treatment with BRAF and MEK inhibitors permitted. A washout period of at least 3-half-lives (median terminal half-life) prior to the first dose of trial treatment must have elapsed.
• Prior therapy with an anti-CTLA4, anti-PD-1, anti-PD-L1, anti-PD-L2 agent or oncolytic virus.
• Men who plan to become a father during the study through 4 months after the last dose of study medication

Más betegség

• Uveal or ocular malignant melanoma
• History of hematologic or primary solid tumor malignancy with the exception of patients in remission for at least 5 years, as judged by the investigator are allowed
• Known hypersensitivity to GM-CSF
• Known history of, or any evidence of active, non-infectious pneumonitis
• History of cardiac disease

Egyéb

• Women who are breastfeeding, pregnant or expect to be pregnant during the study through 6 months after the last dose

• Stage IIIB, IIIC or IV melanoma
• Previously untreated and eligible for pembrolizumab treatment (prior treatment with BRAF and MEK inhibitors permitted) 3) Adequate blood, liver and kidney function 4) Consent to undergo tumor biopsies during the study