Winter-Swimming and Brown Adipose Tissue Activity in Middel-aged Obese Subjects (WinterBAT).

Más betegség

• Any history of Cancer,
• Clinically significant liver, kidney, heart, inflammatory or lung-disease.
• Abnormal ultrasound echocardiography of the heart found at the health-examination day.
• Contraindications to cold exposure including severe Raynauds disease.
• History of alcohol abuse or use of more than 14 units pr. Week.
• History of drug abuse, including marihuana.
• History of contrast allergy.

Laborértékek

• Taking medication (not for hay fever), including glucose-lowering treatment.
• HbA1c >55 mmol/mol and/or 2-h plasma glucose in the 75-g OGTT > 15 mmol/L, fasting plasma glucose above 6.9.
• Increased International Normalised Ratio for coagulation (INR).

Egyéb

• Winter swimmer
• Pregnancy
• Iron deficiency
• Femoral hernia, vene prostheses (pants prosthesis), thrombs in v. Femoralis.
• Smoking including occasional smoking.
• Pacemaker or other electronics implanted in the body.
• Claustrophobia, communication problems, including understanding the experimental protocol.

• Waist circumference above 80 cm for women and 94 cm for men.
• BMI > 25 but <40 kg/m2
• Age > 40 years.
• Low to moderate physical activity level (no physical activity or on average 30 minutes of moderate physical activity per day and not more than 3 hours of training pr. Week)
  • Subjects will be included in either one of these cases after the screening:
• Fasting plasma glucose above 5.6 millimol per liter (mmoL/L).
• HbA1C >39 millimol per mol (mmol/mol).
• 2 hour plasma glucose after a 75 g. oral glucose tolerance test (OGTT) above 7.8 mmol/L.