Systems Biology of Diffusion Impairment in Human Immunodeficiency Virus (HIV)
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Where in Egyesült Államok
- Pittsburgh · University of Pittsburgh department of medicine division of Pulmonary, Allergy and Critical Care medicineIsmeretlen állapot
The registry text, word for word
Systems Biology of Diffusion Impairment in HIV--BoDI
Diffusing capacity for carbon monoxide (DLco) abnormalities are common in HIV+ individuals and associated with significant morbidity and mortality. The complexity and the individualized differences in causes of these abnormalities have been challenging to unravel using traditional approaches. In this proposal, the investigators construct a systems' modeling approach to identify novel molecular and clinical pathways contributing to DLco impairment in HIV+ individuals and to determine predictive signatures of DLco decline in order to develop strategies to treat and prevent abnormal lung function in this susceptible population.
Inclusion: Men and women age 18 to 80; HIV positive and participated in previous HLRC(HIV Lung Research Center) study (PRO10060177, PRO09050521, PRO14070355, PRO08030011, PRO00606151, PRO13050229, PRO17060077); Negative pregnancy test (for women of child barring capabilities); Have undergone bronchoscopy with BAL(bronchial lavage) and/or brushing for AECs in storage; Receiving ART (Anti-Retroviral Therapy)and virally-suppressed for at least 6 months.
Exclusion: Intravenous drug use or alcohol use that will impair ability to complete study investigations in the opinion of the investigator; individuals receiving chronic or acute antibiotics in the prior 4 months; Contraindication to pulmonary function testing (i.e. abdominal or cataract surgery within 3 months, recent myocardial infarction, etc.); Uncontrolled hypertension at screening visit (systolic > 180 mm Hg or diastolic > 100 mm Hg) from an average of two or more readings. Subject may return for screening after blood pressure is controlled; Active cancer requiring systemic chemotherapy or radiation; Active infection of lungs, brain, or abdomen; subjects with an upper or lower respiratory tract infection; Pregnancy or breast-feeding. (urine pregnancy done on all females of child bearing potential-males and females who are at least 1 year post menopausal or surgically sterile will not be tested); Increasing respiratory symptoms or febrile (temperature >100.40F [380C]) within 4 weeks of study entry; Acute cardiopulmonary issue in the past 4 months.