Interventions Against Insulin Resistance in Pulmonary Arterial Hypertension

Korábbi kezelés

• Diagnosis of PAH etiology other than idiopathic, heritable, or associated with drugs or toxins
• Requirement of > 1 diuretic adjustment in the prior 30 days
• Prior diagnosis of cirrhosis

Más betegség

• Prohibited from normal activity due to wheelchair bound status, bed bound status, reliance on a cane/walker, activity-limiting angina, activity-limiting osteoarthritis, or other condition that limits activity
• WHO Functional class IV heart failure
• Type I diabetes mellitus

Laborértékek

• estimated glomerular filtration rate (eGFR) by modification of diet in renal disease (MDRD) <60 milliliters per minute (mL/min)

Egyéb

• Pregnancy
• FEV1> or = 65% predicted AND normal chest imaging
• Preferred form of activity is not measured by an activity tracker (swimming, ice skating, stair master, or activities on wheels such as bicycling or rollerblading)
• Untreated hypo- or hyper-thyroidism

• Diagnosed with idiopathic, heritable, or drug- or toxin-associated pulmonary arterial hypertension (PAH) according to World Health Organization consensus recommendations.
• Stable PAH-specific medication regimen for three months prior to enrollment. Subjects with only a single diuretic adjustment in the prior three months will be included. Adjustments in IV prostacyclin for side effect management are allowed.
• Subjects must own a Bluetooth capable modern smartphone capable of receiving and sending text messages and an active data plan.
• WHO Functional Class I-III
• Ambulatory