Management of Cardiovascular Disease in Kidney Disease (MaCK) Study

Korábbi kezelés

• Prior history of any dialysis within last 12 months, or history of diagnosed AKI in the prior three months
• History of acute cardiovascular event defined as:
  • myocardial infarction
  • stroke or new diagnosis of congestive heart failure or heart failure related admission in prior 3 months
• Life expectancy less than 12 months or uncontrolled congestive heart failure (CHF)
  • defined as more than 2 admissions in prior 6 months)

Más betegség

• G6PD deficiency or known hypersensitivity to 4-aminoquinoline
• History of documented non-adherence to therapy
  • Inability to attend treatment or follow-up scheduling
• Known chronic active infections like HIV, Hepatitis B or Hepatitis C positive, chronic osteomyelitis etc.
• Recent serious infection including requiring hospitalization within 3 months or Recent minor infection such as skin, soft tissue or respiratory infections within 30 days of enrollment
• Active or recently treated (< 1 year in remission) malignancy, transplantation, or systemic inflammatory diseases
  • Patients with localized squamous cell carcinoma of the skin are eligible
• Use of systemic corticosteroids or other immunosuppression within last 3 months (acute course of steroid for a gouty arthritis or chronic obstructive pulmonary disease is eligible if > 1 month ago)
• Any other condition the PI determines may put the research subject in jeopardy during the course of the study

Laborértékek

• Abnormal liver functions or diagnosis of cirrhosis
  • AST and ALT more than 1.5 times the normal or INR without being anti-coagulated greater than 1.4
• History of prolonged QTc interval 450, For patients with BBB an adjusted QT interval >450

Egyéb

• Conventional contraindications for non-contrast MRI examination including
  • Permanent pacemaker
  • Automatic Implantable Cardioverter Defibrillator
  • Significant fear of closed space
  • Claustrophobia that prevents patients from participating
  • Inability to lie down
• Less than 6 months since initiation of 'Statins'
• Pregnancy, breastfeeding or planning to become pregnant during the course of the study
• Recent unexplained weight loss or vision changes

• Veteran
• Age 18-80 years;
• Moderate to severe CKD at the time of screening, defined as one of the following: 1) Stage 3b or 4 CKD with latest eGFR of 25-59, with diabetes mellitus, OR 2) Stage 3b or 4 CKD with latest eGFR of 25 to 45 mL/min and maximum recorded albuminuria defined as urine albumin/creatinine ratio (UACR) of 30 mg/g, OR 3) Stage 3a CKD with eGFR 46-59 ml/min with urine albumin/creatinine (UACR) 100 mg/gm