Deep TMS for Comorbid Depression and Cognitive Impairment in Older Adults

Korábbi kezelés

• have a metal plate in their head, except in the mouth (such as an ear implant, implanted brain stimulators, aneurysm clips)
• have an implanted medication pump

Más betegség

• have known increased pressure or a history of increased pressure in their brain, which may increase their risk for having seizures
• have a cardiac pacemaker
• have a significant heart disease or history of stroke
• have a history of any psychotic disorder, bipolar disorder, eating disorder, obsessive compulsive disorder, post-traumatic stress disorder, or dementia other than AD
• have a history of substance abuse in the last 6 months
• have a history of stroke or other brain lesions
• have a personal history of epilepsy
• have a family history of epilepsy
• are taking psychotropic medications including antidepressant medications, antipsychotics or mood stabilizing medications due to increased risk of seizure
• have a history of abnormal MRI of the brain

Egyéb

• have a central venous line
• Modified Hachinski Score (MHIS) > 3 (to exclude those with significant vascular component to memory loss)
• are a pregnant or breast-feeding woman
• are taking memantine
• have significant hearing loss requiring use of hearing aids
• have untreated hypo- or hyper-thyroidism

• meet DSM 5 criteria for Major or Mild Neurocognitive Disorder due to Alzheimer's disease with Clinical Dementia Rating Scale (CDR) score of at least 0.5
• have been diagnosed with DSM5 Major Depressive Disorder, with the current episode longer than 4 weeks but less than 5 years
• did not respond to or did not tolerate antidepressant treatment
• are willing to provide informed consent
• are able to follow the treatment schedule
• are stable on medications for 2 months and are not expected to change medication during the entire study period (if they are taking medications)
• have a satisfactory safety screening questionnaire for TMS
• have an informant/study partner who is able to complete study questionnaires regarding the participant