ExAblate Blood-Brain Barrier (BBB) Disruption for the Treatment of Alzheimer's Disease

Korábbi kezelés

• Currently in a clinical trial involving an investigational product or non-approved use of a drug or device or in any other type of medical research

Más betegség

• Significant cardiac disease or unstable hemodynamic status
• History of a bleeding disorder
• History of liver disease
• History of seizure disorder or epilepsy
• Chronic pulmonary disorders
• Positive human immunodeficiency virus (HIV)

Egyéb

• MRI Findings
• Presence of unknown or MR unsafe devices anywhere in the body
• Relative contraindications to ultrasound contrast agent or PET amyloid tracer
• Known cerebral or systemic vasculopathy
• Significant depression and at potential risk of suicide
• Any contraindications to MRI scanning
• Any contraindication to lumbar puncture for collection of cerebral spinal fluid
• Untreated, uncontrolled sleep apnea
• Severely Impaired renal function
• Known apolipoprotein E allele (ApoE4) homozygosity

• Male or Female between 50-85 years of age
• Probable Alzheimer's Disease (AD)
• If taking concurrent Alzheimer's medication, has been on the medication for at least 2 months with a stable dose for at least 3 months
• Able to communicate sensations during the ExAblate MRgFUS procedure
• Ambulatory