A Study Comparing Risankizumab to Placebo in Participants With Active Psoriatic Arthritis (PsA) Who Have a History of Inadequate Response to or Intolerance to at Least One Disease Modifying Anti-Rheumatic Drug (DMARD) Therapy

Korábbi kezelés

• Participant has previous treatment with biologic agent.

Más betegség

• Participant has a known hypersensitivity to risankizumab.

Egyéb

• Participant is considered by investigator, for any reason, to be an unsuitable candidate for the study.

• Clinical diagnosis of PsA with symptom onset at least 6 months prior to the Screening Visit and fulfillment of the Classification Criteria for PsA (CASPAR) at the Screening Visit.
• Participant has active disease at Baseline defined as ≥ 5 tender joints (based on 68 joint counts) and ≥ 5 swollen joints (based on 66 joint counts)
• Diagnosis of active plaque psoriasis with at least one psoriatic plaque of ≥ 2 cm diameter or nail changes consistent with psoriasis at Screening Visit.
• Participant has demonstrated an inadequate response or intolerance to or contraindication for conventional synthetic disease modifying anti-rheumatic drugs (csDMARD) therapy(ies).
• Presence of either at Screening:
  • ≥ 1 erosion on radiograph as determined by central imaging review or;
  • High sensitivity C-reactive protein (hsCRP) ≥ 3.0 mg/L.