Study of Porcine Fibrin Sealant in Preventing Cervical Anastomotic Leakage (PLACE030)

Korábbi kezelés

• Patients with concomitant hemorrhagic disease
• Patients with other uncontrollable status that cannot tolerate surgery
• Patients with concomitant peripheral neuropathy, whose CTC status is 2 or even more

Más betegség

• Patients with known hypersensitivity to the porcine fibrin sealant product
• Have a history of diabetes over 10 years and with poorly controlled blood sugar level
• Patients with serious cardiac, respiratory, hepatic, renal,hematologic, immunological disease or cachexy, who cannot tolerate surgery

Egyéb

• Patients who have undergone definitive chemoradiotherapy
• Pregnant or breast feeding
• Patients cannot signed the informed consent document because of psychological quality, family and social factors

• Histologic diagnosis of squamous cell carcinoma or adenocarcinoma of thoracic esophageal carcinoma or gastroesophageal junction cancer with Stage T1-4aN0-3M0, according to 8th edition of Union for International Cancer Control (UICC) staging system
• More than 6 months of expected survival
• Age ranges from 18 to75 years
• Absolute white blood cells count ≥4.0×109/L, neutrophil ≥1.5×109/L, platelets ≥100.0×109/L, hemoglobin ≥90g/L, and normal functions of liver and kidney.
• WHO performance status (PS) of 0-1
• Informed consent will be obtained before the study