Yield of Diagnostic Tests and Effects of Crofelemer for Chronic Idiopathic Diarrhea In Non-HIV Patients

Korábbi kezelés

• Pregnant females (crofelemer is a Category C drug due to lack of well-controlled studies to study its effects in this population).
• Persons receiving antibiotics currently or have received antimicrobials in the past 4 weeks.
• Persons receiving chemo-radiation or immune-modulators for oncologic or rheumatologic conditions.
• Gluten free diet for previous 3 months and refusal to ingest gluten.

Más betegség

• HIV positive individuals.
• Persons with history of alcohol abuse or binge drinking.
• Persons with history of surgical bowel resection or bariatric surgery in the past 12 months.
• Persons with end-organ failures including end-stage renal disease, end-stage liver disease, or severe heart failure.
• Persons with metastatic hematologic and oncologic malignancies.
• Persons with any other known organic gastrointestinal or non-gastrointestinal disease process in which diarrhea is a recognized clinical feature.

Életkor

• Subjects less than 18 years of age more than 75 years of age (safety and effectiveness of crofelemer has not been established in these age groups).

Egyéb

• Hematochezia (potentially related to an organic cause).
• Lactating females (it is unknown if crofelemer is excreted in the human milk and thus may have unknown adverse effects on the nursing infants).
• Persons within ability to provide consent and understand the study
• Persons who have undergone cholecystectomy (open or laparoscopic) in the past 3 months.

• Patients with chronic diarrhea (defined as 3 non-bloody loose stools per day or more than 20 non-bloody loose stools per week for more ≥ 4 weeks) and Bristol Stool Form Scale for stool consistency of 6/7 with >50% stool without an obvious cause after evaluation for organic etiologies.
• Patients from any ethnicity