A Study of the Pan-immunotherapy in Patients With Relapsed/Refractory Ovarian Cancer

Korábbi kezelés

• Prior organ allograft.
• Women with a positive pregnancy test on enrollment or prior to investigational product administration.
• Subjects with previous or concurrent other malignancies.

Más betegség

• Subjects with any autoimmune disease or history of syndrome that requires corticosteroids or immunosuppressive medications.
• Serious uncontrolled medical disorders or active infections, pulmonary infection especially.
• Subjects who are compulsorily detained for treatment of either a psychiatric or physical (eg, infectious disease) illness.

Egyéb

• Women who are pregnant or breastfeeding.

• Subjects must have histologically proven relapsed or refractory ovarian cancer (Refractory was defined as a lack of response to or progression during the frontline treatment; relapsed was defined as progression after the frontline treatment), including patients diagnosed with primary carcinoma of fallopian tube or peritoneum carcinoma.
• Female.
• ≥ 18 years old.
• Life expectancy of at least 6 months.
• Eastern Cooperative Oncology Group performance status 0-2.
• Radiographic imaging (CT/MRI/PET-CT) indicated recurrence or metastasis; or cancer cells in ascites are positive; or CA125 concentration in the peripheral blood is more than 2 times the upper limit of normal value.
• Subjects must have received at least two frontline therapies, at least one of which is platinum-containing.
• Subjects with Anti-PD-1 antibody treatment history are eligible which must be resistance.
• Adequate organ function.
• Female participants of childbearing potential must be willing to use an adequate method of contraception for the course of the study through 120 days after the last dose of study drug.