Alternate Day Fasting, Exercise, and NAFLD

Korábbi kezelés

• Are not weight stable for 3 months prior to the beginning of study (weight gain or loss \> 4 kg)
• Are taking drugs that induce steatosis (e.g. corticosteroids, estrogens, methotrexate, Ca channel blockers)
• Are taking drugs that benefit NAFLD (e.g. betaine, pioglitazone, rosiglitazone, metformin, or gemifibrozil)
• Are taking drugs that influence study outcomes (weight loss medications)

Más betegség

• Have chronic liver disease other than NAFLD (hepatitis B or C, primary biliary cirrhosis, sclerosing cholangitis, autoimmune hepatitis, hemochromatosis, Wilson's disease, α1-antitrypsin deficiency)
• Have a history of known cardiovascular, pulmonary or renal disease
• Are claustrophobic or have implanted metallic/electrical devices (e.g. cardiac pacemaker, neuro-stimulator)

Egyéb

• Consume excessive amounts of alcohol women: 70 g of ethanol (5 alcoholic drinks per week) and men 140 g of ethanol (10 drinks per week) in the past 6 months)
• Diagnosed T1DM or T2DM
• Are perimenopausal or have an irregular menstrual cycle (menses that does not appear every 27-32 days)
• Are pregnant, or trying to become pregnant
• Are smokers

• Age between 18 to 65 years old
• BMI between 30.0 and 59.9 kg/m2
• NAFLD (hepatic steatosis ≥ 5% confirmed by MRI-PDFF)
• Sedentary (\<20 min, 2x/week of light activity at 3-4 metabolic equivalents (METs) for 3 mo prior to study)