Aspirin and a PoTent P2Y12 Inhibitor Versus Aspirin and Clopidogrel in Patients Undergoing PCI for Complex Lesion

Korábbi kezelés

• ③ Previous history of intracerebral hemorrhage, transient ischemic attack, or stroke

Más betegség

• ② Subjects with serious bleeding (Intracerebral hemorrhage, gastrointestinal bleeding, hematuria, hemoptysis, and etc.)
• ④ Known hypersensitivity or contraindications to study medications (aspirin, clopidogrel, and prasugrel)
• ⑥ Non-cardiac co-morbid conditions are present with life expectancy <1 year or that may result in protocol non-compliance (per site investigator's medical judgment)
• ⑦ Patients presenting with biomarker positive acute coronary syndrome
• ⑩ Patients taking warfarin or novel oral anticoagulants (dabigatran, rivaroxaban, edoxaban, or apixaban)
  • Eligible patients will be randomly assigned to treatment arms, stratified by participating centers, presence of diabetes mellitus, and stent types.

Életkor

• ⑨ Subjects ≥75 years of age or <60 kg of body weight

Egyéb

• ① Hemodynamic instability or cardiogenic shock
• ⑤ Female of childbearing potential, unless a recent pregnancy test is negative, who possibly plan to become pregnant any time after enrollment into this study
• ⑧ Patients chronically taking prasugrel or ticagrelor (≥1 week)

• ① Subject must be at least 19 years of age
• ② Subject who can verbally confirm understandings of risks, benefits and treatment alternatives and he/she or his/her legally authorized representative provides written informed consent prior to any study related procedure
• ③ Patients undergoing elective PCI as follows:
  • True bifurcation lesion (Medina 1,1,1/1,0,1/0,1,1) with side branch ≥2.5 mm size
  • Chronic total occlusion (≥3 months) as target lesion
  • PCI for unprotected left main disease (left main ostium, body, or distal bifurcation including non-true bifurcation lesions)
  • Long coronary lesions (expected stent length ≥38 mm)
  • Multi-vessel PCI (≥2 vessels treated at one PCI session)
  • Multiple stent needed (≥3 stents per patient)
  • In-stent restenosis lesion as target lesion
  • Severely calcified lesion (encircling calcium in angiography)
  • Ostial lesions of left anterior descending artery, left circumflex artery, or right coronary artery