Perioperative Epidural Block and Dexamethasone in Pancreatic Cancer Surgery

Korábbi kezelés

• Previous surgery for pancreatic cancer, scheduled to undergo resurgery for recurrence or metastasis;
• Complicated with primary malignant tumor in other organ(s), either previously or at present;
• Complicated with autoimmune diseases, receiving either glucocorticoids or other immunosuppressants before surgery;

Más betegség

• Clinical evidence of unresectable pancreatic cancer or plan to undergo biopsy;
• Unable to complete preoperative evaluation due to severe dementia, language barrier, coma, or end-stage diseases;
• Contradictions to epidural anesthesia, including spinal malformation, history of spinal surgery, coagulation disorder, suspected infection at the site of puncture, or severe low back pain;
• Other conditions that are considered unsuitable for study participation;

Laborértékek

• Severe hepatic dysfunction (Child-Pugh C), severe renal insufficiency (serum creatinine \>442 µmol/L or requirement of renal replacement therapy), or American Society of Anesthesiologists classification ≥V；

Egyéb

• Refused to participate in the study.

• Age ≥45 and \<90 years;
• Clinically diagnosed as resectable or possibly resectable pancreatic cancer and scheduled to undergo radical surgery;
• Agreed to receive epidural block and postoperative patient-controlled analgesia;
• Agreed to participate in the study and provided written informed consent.