The Bacterial Secretome in IBD

Más betegség

• Diagnosis of IBD or any other inflammatory condition of the small and large intestine
• Autoimmune disorders
• Intestinal infection by enteric pathogens
• Probiotic therapy
  • Group 2 (Crohn´s disease; CD): n= 20 (10 active CD; 10 inactive CD)
• Intestinal infection by enteric pathogens
  • Definition of active CD Harvey-Bradshaw Index - HBI ≥ 5 and / or Simple Endoscopic Score for Crohn Disease (SES-CD) ≥ 3
  • Except SES-CD scores resulting from isolated lesions only located at the ileocolonic anastomosis consistent with a modified Rutgeerts score i2a (these patients are considered as endoscopically non active)
  • Definition of inactive CD
  • Harvey-Bradshaw Index (HBI) < 5 and Simple Endoscopic Score for Crohn Disease (SES-CD) < 3
  • Except SES-CD scores resulting from isolated lesions only located at the ileocolonic anastomosis consistent with a modified Rutgeerts score i2a (these patients are considered as endoscopically non active)
  • Group 3 (Ulcerative colitis, UC): n= 20 (10 active UC; 10 inactive UC)
• Intestinal infection by enteric pathogens
  • Definition of active UC Total Mayo score ≥ 3 and Endoscopic Mayo subscore ≥ 2
  • Definition of inactive UC Total Mayo score < 3 and Endoscopic Mayo subscore 0 or 1.
  • Group 4 (Colorectal cancer): n= 10

Egyéb

• Diagnosis of IBS
• Obesity (BMI> 30)
• Regular intake of NSAIDs (> 2 tablets/ week), immunosuppressants
• Intake of antibiotics within the last 3 months
• None
  • Group 5 (Colitis/Enteritis of different origin): n= 20
• None

• Colonoscopy performed for the following indications: anemia, blood in stool, constipation, change in bowel habits, screening for colon cancer, follow up after polyps, weight loss
• Macroscopic normal colonoscopy except for diverticulosis (without any signs of inflammation), ≤ 3 polyps (except hyperplastic polyps of the colon and rectum), angiodysplasia
• Colonoscopy indicated by routine clinical care
• Established diagnosis of Crohn´s disease (also if established by the study colonoscopy)
• Colonoscopy indicated by routine clinical care
• Established diagnosis of ulcerative colitis (also if established by the study colonoscopy)
• Diagnosis of a lesion with suspicion for colorectal cancer during endoscopy which is confirmed later by histology
• Diagnosis of intestinal inflammation at endoscopy or histology
• E.g.: Infectious colitis /enteritis; ischemic Colitis; microscopic colitis; GVHD; NSAID colitis; Colitis of unknown cause

A regiszterben nem jelölt feltételek

• Group 1 (healthy controls): n=20