Blood PREssure Augmentation in Large-vessel Occlusion Stroke Study

Korábbi kezelés

• Participation in any investigational study in the previous 30 days
• Treatment with Monoamine oxidase inhibitors (MAO-I) within last 7 days

Más betegség

• Intracranial hemorrhage (ICH) identified by CT or MRI
• A history of a left ventricular heart failure (NYHA Class ≥ III, or EF < 50%) or angina (either unstable or CCS Grade II) involving symptoms at rest or with ordinary physical activity
• Acute myocardial infarction in the past 6 months
• Signs or symptoms of acute myocardial infarction, including electrocardiogram find-ings, on admission

Laborértékek

• Elevated serum troponin concentration on admission (>0.1 μg/L)

Egyéb

• Baseline SBP>200 mm Hg
• Inability to access the cerebral vasculature in the opinion of the neurointerventional team
• Contraindication to imaging with MR
• Suspicion of aortic dissection on admission

• Age is ≥18 years
• Patients presenting with anterior circulation acute ischemic stroke
• Enrollment within 24 hours of stroke onset
• Treatment with endovascular thrombectomy
• Arterial occlusion on CTA or MRA of the ICA, M1 or M2
• Mismatch - Using CT or MRI with a Tmax >6 second delay perfusion volume and either CT-rCBF or DWI infarct core volume.
  • Mismatch ratio of greater than 1.8, and
  • Absolute mismatch volume of greater than 15 ml, and
  • Infarct core lesion volume of less than 70 mL