MIcrovascular dysfuNction In Moderate-severe Psoriasis

Korábbi kezelés

• Prior history of untreated chronic infection (tuberculosis), severe fungal infection, or known HIV positive, chronic hepatitis B or C infection), prior history of active solid malignancy, myeloproliferative or lymphoproliferative disease within 5 years, excluding treated non-melanoma skin cancer
• Patients requiring chronic treatment with oral prednisone >10mg/day, methotrexate, or other immunosuppressive agents.

Más betegség

• Documented history of other systemic inflammatory diseases, including SLE and RA, which in the opinion of the investigator would be inappropriate for enrollment.
• Renal insufficiency (CrCl <40 ml/min)
• NYHA class IV heart failure

Egyéb

• Pregnancy and Breastfeeding

• Moderate-to-severe psoriasis
• Ages 18-90
• Body surface area (BSA) involvement ≥ 3% OR 5-point Physician Global Assessment (PGA) Score ≥ 3 OR Psoriasis Area and Severity Index (PASI) score ≥ 12
• Patients who have failed biologic therapy, topical steroids, phototherapy, or other systemic therapies will be required to have a wash-out period, which will be calculated accordingly to the specific drug (Appendix 1)
• Evidence of at least one cardiovascular risk factor which includes hsCRP ≥ 2 mg/L, DM, obesity (BMI>25), hyperlipidemia, hypertension, family history of early coronary artery disease, or evidence of metabolic syndrome
  • ---Metabolic syndrome defined as at least three of the following: glucose>100mg/dl or taking hypoglycemic agent, HDL<40mg/dl (men) or 50 mg/dl (women), triglycerides ≥150mg/dl, waist circumference >40 in mean or >35 in women, or blood pressure ≥130/85 or taking anti-hypertensive.
• If the patient is on a statin therapy, they must be on a stable dose for at least 6 months prior to enrollment.

A regiszterben nem jelölt feltételek

• In order for an individual to participate, they must meet all of the inclusion and exclusion criteria as outlined below.