NCT04339738Fut, nem toboroz2. fázis
Testing the Addition of Nivolumab to Chemotherapy in Treatment of Soft Tissue Sarcoma
A Multicenter Phase II Trial of Paclitaxel With and Without Nivolumab in Taxane Naive, and Nivolumab and Cabozantinib in Taxane Pretreated Subjects With Angiosarcoma
Forrás: ClinicalTrials.gov · Utoljára frissítve: 2026. szept. 8.
Rövid összefoglaló (regiszter, angolul)
This phase II trial studies how well paclitaxel with and without nivolumab works in treating patients with soft tissue sarcoma that have not received taxane drugs, and how well nivolumab and cabozantinib work in treating taxane pretreated patients with soft tissue sarcoma. Nivolumab works through the body's immune system to help the immune system act against tumor cells. Chemotherapy drugs, such as paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Cabozantinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. This trial is being done to see if the combination of nivolumab and paclitaxel or cabozantinib can shrink soft tissue sarcoma and possibly prevent it from coming back.
- Állapot (regiszter)
- Fut, nem toboroz
- Fázis (regiszter)
- 2. fázis
- Vizsgálattípus
- Beavatkozással járó
- Résztvevők száma
- 90 (tényleges)
- Első benyújtás
- 2020. ápr. 8.
- Kezdés
- 2020. nov. 4.
- Elsődleges befejezés
- 2025. márc. 30.
- Fő szponzor
- National Cancer Institute (NCI)
- Betegségek
- Szarkóma
- NCT-szám
- NCT04339738
Mit vállalsz
- Vizsgálat típusa: Beavatkozással járó · 2. fázis
- Bevont résztvevők: 90
- 2020. nov. 4. és az elsődleges befejezés (2025. márc. 30.) között
- 171 helyszín, 2 országban
- Vizitek és vizsgálatok: kérdezd a vizsgálat csapatát, a regiszter nem sorolja fel őket
A(z) ClinicalTrials.gov regisztermezőiből összeállítva. A vizsgálat felépítését írja le.
Ki nem vehet részt
Szó szerint a(z) ClinicalTrials.gov forrásból, témák szerint csoportosítva. Hogy ki vehet részt, azt csak a vizsgálat csapata dönti el.
Kiket keres a vizsgálat
- Histologically confirmed cutaneous or visceral angiosarcoma, where curative treatment is either not possible or curative modality therapy is declined by the subject. Note: If a subject declines curative modality therapy, the reason must be documented (e.g. excessive morbidity to necessary surgery)
- Note: Radiation induced angiosarcomas are permitted
- All local diagnostic slides AND 5 x 4-6 micron unstained slides from diagnostic tumor tissue should be available for retrospective central pathology review
- Must have measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1. Per RECIST v1.1, clinical lesions will only be considered measurable when they are superficial and >= 10 mm diameter as assessed using calipers or ruler (e.g. skin nodules). For the case of skin lesions, documentation by color photography including a ruler to estimate the size of the lesion is required. When lesions can be evaluated by both clinical exam and imagining, imaging evaluation should be undertaken since it is more objective and may also be reviewed at the end of the study. The same method of measurement should be used throughout the study, preferably performed by the same investigator. Areas previously radiated must have demonstrated disease progression at some point over the past 6 months and growth must be subsequent to the last line of anti-cancer directed therapy (e.g. chemotherapy, radiation therapy, surgery)
- Not pregnant and not nursing, because this study involves an investigational agent whose genotoxic, mutagenic and teratogenic effects on the developing fetus and newborn are unknown
- Therefore, for women of childbearing potential only, a negative pregnancy test done =< 3 days prior to registration is required
- Age >= 18 years
- Eastern Cooperative Oncology Group (ECOG) performance status 0-1
- Prior Treatment
- Patient must have completed all prior cancer directed therapies (including investigational) >= 7 days prior to cycle 1 day 1
- Exception: prostate patients who are allowed to concurrently receive androgen suppression therapy
- Note: Radiation therapy must be completed >= 7 days of day 1 of study treatment, and must not be expected to significantly impact blood count recovery
- There is no limit to overall number of prior lines of therapy
- No prior PD-1 inhibitor or PD-L1 inhibitor therapy is permitted
- No prior administration of VEGF TKI therapy is permitted
- Recovery to baseline or' =< grade 1 CTCAE version 5.0 from toxicity related to any prior treatment, unless adverse events are clinically non-significant and/or stable on supportive therapy, with the exception of fatigue (which should be =< grade 2) or alopecia. Note: Patients should be expected to have experienced any nadir and have adequate blood count recovery prior to cycle 1 day 1
- Taxane Naive Patients Only: No prior exposure to taxane therapy of any duration for angiosarcoma
- Taxane Pre-treated Patients Only (Effective 10/28/2021, new patient accrual to Arm 3 was permanently closed): Prior taxane therapy is allowed at any point prior to registration as long as prior treatment eligibility criteria are met prior to cycle 1 day 1
- No major surgery (except the diagnostic biopsy) =< 28 days of study registration. Procedures such as thoracentesis, paracentesis, percutaneous biopsy, Lasik eye surgery are not considered major surgery. Subjects with clinically relevant ongoing complications from prior surgery are not eligible
- Absolute neutrophil count (ANC) >= 1,500/mm\^3
- Platelet count >= 100,000/mm\^3
- Hemoglobin >= 9.0 g/dL
- Calculated (Calc.) creatinine clearance >= 30 mL/min (per Cockcroft-Gault)
- Total bilirubin =< 1.5 x upper limit of normal (ULN)
- For patients with documented/suspected Gilbert's disease, bilirubin =< 3 x ULN
- Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN)
- For patients with significant hepatic metastases, ALT and AST =< 5 x ULN. No clinically active or chronic liver disease resulting in moderate/severe hepatic impairment (Child-Pugh class B or C), ascites, coagulopathy or bleeding due to liver dysfunction
- Urine protein:creatinine (UPC) ratio < 1 or urine protein =< 1+ (Only for Arm 3 Taxane pre-treated and crossover patients)
- No uncontrolled central nervous system (CNS) metastases. Patients with history of CNS metastasis will be allowed as long as the metastatic sites were adequately treated as demonstrated by clinical and radiographic improvement, and the patient has recovered from the intervention (no residual adverse events > CTCAE grade 1), and the patient has remained without recurrence of new or worsening CNS symptoms for a period of 28 days prior to registration. Treated CNS metastasis (mets) should have no ongoing requirement for steroids, and no evidence of hemorrhage after treatment for at least 28 days prior to registration
- No uncontrolled intercurrent illness that would put the patient at undue risk by participation in the study, in the opinion of the investigator
- No history of syncope of cardiovascular etiology, uncontrolled cardiac arrhythmia, history of Mobitz II second degree or third degree heart block without a permanent pacemaker in place, myocardial ischemia or infarction, severe or unstable angina, New York Heart Association (NYHA) class II to IV heart failure, or stroke/transient ischemic attack (TIA) within the past 3 months
- No thromboembolic event (e.g., deep venous thrombosis, pulmonary embolism) within 1 month before randomization. Subjects with a diagnosis of incidental, subsegmental pulmonary embolism (PE) or deep vein thrombosis (DVT) within 6 months are allowed if stable, asymptomatic, and treated with low molecular weight heparin (LMWH) for at least 2 weeks before first dose. Iatrogenic arterial embolization procedures such as tumor arterial embolization or splenic artery embolization are allowed
- Patients with a requirement for steroid treatment or other immunosuppressive treatment: Patients should be excluded if they have a condition requiring systemic treatment with either corticosteroids (> 10 mg daily prednisone equivalents) or other immunosuppressive medications within 14 days of study drug administration. Inhaled or topical steroids and adrenal replacement doses > 10 mg daily prednisone equivalents are permitted in the absence of active autoimmune disease. Patients are permitted to use topical, ocular, intra-articular, intranasal, and inhalational corticosteroids (with minimal systemic absorption). A brief course of corticosteroids for prophylaxis (e.g., contrast dye allergy) or for treatment of non-autoimmune conditions (e.g., delayed-type hypersensitivity reaction caused by contact allergen) is permitted
- Patients are permitted to enroll if they have vitiligo, type I diabetes mellitus, residual hypothyroidism due to autoimmune condition only requiring hormone replacement, psoriasis not requiring systemic treatment, or conditions not expected to recur in the absence of an external trigger (precipitating event)
- Active autoimmune disease requiring systemic treatment (i.e. disease modifying agents, corticosteroids, or immunosuppressive drugs) within the past 2 years. These include but are not limited to patients with a history of immune-related neurologic disease, multiple sclerosis, autoimmune (demyelinating) neuropathy, Guillain-Barre syndrome, myasthenia gravis; systemic autoimmune disease such as systemic lupus erythematosus (SLE), rheumatoid arthritis, connective tissue diseases, scleroderma, inflammatory bowel disease (IBD), Crohn's, ulcerative colitis, hepatitis; and patients with a history of toxic epidermal necrolysis (TEN), Stevens-Johnson syndrome, or phospholipid syndrome should be excluded because of the risk of recurrence or exacerbation of disease
- Note: Patients are permitted to enroll if they have vitiligo; type I diabetes mellitus; hypothyroidism, pituitary or adrenal insufficiency requiring only hormone replacement; psoriasis not requiring systemic treatment, or conditions not expected to recur in the absence of an external trigger (precipitating event)
- Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial
- No planned palliative procedures for alleviation of pain such as radiation therapy or surgery
- No untreated or impending spinal cord compression or evidence of spinal metastases with a risk of impending fracture or spinal cord compression
- No known or suspected contraindications or hypersensitivity to paclitaxel, cabozantinib or nivolumab or to any of the excipients
- Disorders associated with a high risk of perforation or fistula formation: active inflammatory bowel disease, active diverticulitis, active cholecystitis, active symptomatic cholangitis or active appendicitis, active acute pancreatitis or active acute obstruction of the pancreatic or biliary duct, or active gastric outlet obstruction; abdominal fistula, gastrointestinal perforation, bowel obstruction, or intra-abdominal abscess within 6 months before randomization. Note: Complete healing of an intra-abdominal abscess must be confirmed before randomization
- No clinically significant hematuria, hematemesis, or hemoptysis, or other history of significant bleeding (e.g., pulmonary hemorrhage) within 3 months before randomization
- No lesions invading major pulmonary blood vessels
- No other clinically significant disorders: uncompensated/symptomatic hypothyroidism; requirements for hemodialysis or peritoneal dialysis; history of solid organ transplantation
- Serious non-healing wounds unrelated to cancer are excluded
- Note: Wounds that are cutaneous angiosarcoma are allowed
- Chronic concomitant treatment with strong inhibitors and inducers of CYP3A4 is not allowed on this study. Patients on strong CYP3A4 inhibitors and inducers must discontinue the drug 7 days and 14 days, respectively prior to registration on the study
- Taxane Naive Patients Only: No clinically significant neuropathy (grade >= 2 per NCI CTCAE v5.0)
- Taxane Pre-treated only (Effective 10/28/2021, new patient accrual to Arm 3 was permanently closed):
- Stroke (including transient ischemic attack [TIA]), myocardial infarction (MI), or other ischemic event, or thromboembolic event (e.g., deep venous thrombosis, pulmonary embolism) within 6 months before first dose. Subjects with a diagnosis of DVT within 6 months are allowed if stable and treated with LMWH for at least 2 weeks before first dose
- No history of clinically significant coagulopathy
- No uncontrolled hypertension, defined as systolic blood pressure of > 140 mmHg or diastolic pressure > 90 mmHg on anti-hypertensive medications
- No known or suspected gastrointestinal disorder affecting absorption of oral medications (for patients getting cabozantinib)
- No clinical, laboratory or radiographic evidence of an active bacterial, fungal, or viral infection requiring treatment at the time of registration. No concurrent use of parenteral (IV) antibiotics is permitted. Oral antibiotics administered for a defined course with expectation of resolution of infection are permitted at the discretion of the investigator
- No use of ongoing systemic steroid therapy within 7 days prior to study registration. Dose equivalence of prednisone 10mg daily or less is permitted
- Taxane Pre-treated only:
- No current use of aspirin (> 81 mg/day), or any other antiplatelet agents
- Concomitant anticoagulation with oral anticoagulants (e.g., warfarin, direct thrombin inhibitors, and factor Xa inhibitors) or platelet inhibitors (e.g., clopidogrel) is not permitted. Low-dose (prophylactic) low molecular weight heparins (LMWH) are permitted. Anticoagulation with therapeutic doses of LMWH is allowed in subjects with no known brain metastases, no clinically significant hemorrhage, or no complications from a thromboembolic event on the anticoagulation regimen, and who have been on a stable dose of LMWH for at least 2 weeks before first dose
- Patients must be able to speak and comprehend English or Spanish in order to complete the mandatory patient-completed measures
- Re-Registration Eligibility Criteria (upon progression on Arm 2 only): Not pregnant and not nursing, because this study involves an investigational agent whose genotoxic, mutagenic and teratogenic effects on the developing fetus and newborn are unknown
- Therefore, for women of childbearing potential only, a negative pregnancy test done =< 3 days prior to re-registration is required
- Re-Registration Eligibility Criteria (upon progression on Arm 2 only): Age >= 18 years
- Re-Registration Eligibility Criteria (upon progression on Arm 2 only): ECOG performance status 0-1
- Re-Registration Eligibility Criteria (upon progression on Arm 2 only): Prior Treatment
- Patient must have completed all prior treatments (including investigational Arm 2 paclitaxel) >= 28 days prior to cycle 1 day 1
- Exception: prostate patients who are allowed to concurrently receive androgen suppression therapy
- Note: Re-registration is only permitted after progression on Arm 2
- No prior PD-1 inhibitor or PD-L1 inhibitor therapy is permitted
- Recovery to baseline, or =< grade 1 CTCAE version 5.0 from toxicity related to any prior treatment, unless adverse events are clinically non-significant and/or stable on supportive therapy, with the exception of fatigue (which should be =< grade 2) or alopecia. Note: Patients should be expected to have experienced any nadir and have adequate blood count recovery prior to cycle 1 day 1
- Re-Registration Eligibility Criteria (upon progression on Arm 2 only): No major surgery (except the diagnostic biopsy) =< 28 days of study re-registration. Procedures such as thoracentesis, paracentesis, percutaneous biopsy, Lasik eye surgery are not considered major surgery. Subjects with clinically relevant ongoing complications from prior surgery are not eligible
- Re-Registration Eligibility Criteria (upon progression on Arm 2 only): Absolute neutrophil count (ANC) >= 1,500/mm\^3
- Re-Registration Eligibility Criteria (upon progression on Arm 2 only): Platelet count >= 100,000/mm\^3
- Re-Registration Eligibility Criteria (upon progression on Arm 2 only): Hemoglobin >= 9.0 g/dL
- Re-Registration Eligibility Criteria (upon progression on Arm 2 only): Calc. creatinine clearance >= 30 mL/min (per Cockcroft-Gault)
- Re-Registration Eligibility Criteria (upon progression on Arm 2 only): Total bilirubin =< 1.5 x upper limit of normal (ULN)
- For patients with documented/suspected Gilbert's disease, bilirubin =< 3 x ULN
- Re-Registration Eligibility Criteria (upon progression on Arm 2 only): AST/ALT =< 2.5 x upper limit of normal (ULN)
- For patients with significant hepatic metastases, ALT and AST =< 5 x ULN. No clinically active or chronic liver disease resulting in moderate/severe hepatic impairment (Child-Pugh class B or C), ascites, coagulopathy or bleeding due to liver dysfunction
- Re-Registration Eligibility Criteria (upon progression on Arm 2 only): UPC ratio < 1 or urine protein =< 1+
- Re-Registration Eligibility Criteria (upon progression on Arm 2 only): No uncontrolled CNS metastases. Patients with history of CNS metastasis will be allowed as long as the metastatic sites were adequately treated as demonstrated by clinical and radiographic improvement, and the patient has recovered from the intervention (no residual adverse events > CTCAE grade 1), and the patient has remained without recurrence of new or worsening CNS symptoms for a period of 28 days prior to registration. Treated CNS mets should have no ongoing requirement for steroids, and no evidence of hemorrhage after treatment for at least 28 days prior to registration
- Re-Registration Eligibility Criteria (upon progression on Arm 2 only): No uncontrolled intercurrent illness that would put the patient at undue risk by participation in the study, in the opinion of the investigator
- Re-Registration Eligibility Criteria (upon progression on Arm 2 only): No history of syncope of cardiovascular etiology, uncontrolled cardiac arrhythmia, History of Mobitz II second degree or third degree heart block without a permanent pacemaker in place, myocardial ischemia or infarction, severe or unstable angina, New York Heart Association (NYHA) class II to IV heart failure, or stroke/transient ischemic attack (TIA) within the past 3 months
- Re-Registration Eligibility Criteria (upon progression on Arm 2 only): No thromboembolic event (e.g., deep venous thrombosis, pulmonary embolism) within 1 month before randomization. Subjects with a diagnosis of incidental, subsegmental PE or DVT within 6 months are allowed if stable, asymptomatic, and treated with LMWH for at least 2 weeks before first dose. Iatrogenic arterial embolization procedures such as tumor arterial embolization or splenic artery embolization are allowed
- Re-Registration Eligibility Criteria (upon progression on Arm 2 only): Patients with a requirement for steroid treatment or other immunosuppressive treatment: Patients should be excluded if they have a condition requiring systemic treatment with either corticosteroids (> 10 mg daily prednisone equivalents) or other immunosuppressive medications within 14 days of study drug administration. Inhaled or topical steroids and adrenal replacement doses > 10 mg daily prednisone equivalents are permitted in the absence of active autoimmune disease. Patients are permitted to use topical, ocular, intra-articular, intranasal, and inhalational corticosteroids (with minimal systemic absorption). A brief course of corticosteroids for prophylaxis (e.g., contrast dye allergy) or for treatment of non-autoimmune conditions (e.g., delayed-type hypersensitivity reaction caused by contact allergen) is permitted
- Re-Registration Eligibility Criteria (upon progression on Arm 2 only): Active autoimmune disease requiring systemic treatment (i.e. disease modifying agents, corticosteroids, or immunosuppressive drugs) within the past 2 years. These include but are not limited to patients with a history of immune-related neurologic disease, multiple sclerosis, autoimmune (demyelinating) neuropathy, Guillain-Barre syndrome, myasthenia gravis; systemic autoimmune disease such as SLE, rheumatoid arthritis, connective tissue diseases, scleroderma, inflammatory bowel disease (IBD), Crohn's, ulcerative colitis, hepatitis; and patients with a history of toxic epidermal necrolysis (TEN), Stevens-Johnson syndrome, or phospholipid syndrome should be excluded because of the risk of recurrence or exacerbation of disease
- Note: Patients are permitted to enroll if they have vitiligo; type I diabetes mellitus; hypothyroidism, pituitary or adrenal insufficiency requiring only hormone replacement; psoriasis not requiring systemic treatment, or conditions not expected to recur in the absence of an external trigger (precipitating event)
- Re-Registration Eligibility Criteria (upon progression on Arm 2 only): HIV-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial
- Re-Registration Eligibility Criteria (upon progression on Arm 2 only): No planned palliative procedures for alleviation of pain such as radiation therapy or surgery
- Re-Registration Eligibility Criteria (upon progression on Arm 2 only): No untreated or impending spinal cord compression or evidence of spinal metastases with a risk of impending fracture or spinal cord compression
- Re-Registration Eligibility Criteria (upon progression on Arm 2 only): No known or suspected contraindications or hypersensitivity to cabozantinib or nivolumab or to any of the exc
Életkor a regiszterben: 18 év – - · Nem: nők és férfiak · Egészséges önkénteseket nem fogad
Helyszínek (171)
Helyszínek a regiszter sorrendjében. Ha a profilodba mented a városodat, távolság szerint rendeződnek.
| Helyszín | Város | Ország | Helyszín állapota |
|---|---|---|---|
| FHP Health Center-Guam | Tamuning | Guam | Ismeretlen állapot |
| The Cancer Center of Hawaii-Pali Momi | ‘Aiea | Egyesült Államok | Ismeretlen állapot |
| Pali Momi Medical Center | ‘Aiea | Egyesült Államok | Ismeretlen állapot |
| Queen's Cancer Center - Pearlridge | ‘Aiea | Egyesült Államok | Ismeretlen állapot |
| Hawaii Cancer Care - Westridge | ‘Aiea | Egyesült Államok | Ismeretlen állapot |
| OSF Saint Anthony's Health Center | Alton | Egyesült Államok | Ismeretlen állapot |
| Mary Greeley Medical Center | Ames | Egyesült Államok | Ismeretlen állapot |
| McFarland Clinic - Ames | Ames | Egyesült Államok | Ismeretlen állapot |
| University of Michigan Rogel Cancer Center | Ann Arbor | Egyesült Államok | Ismeretlen állapot |
| Emory University Hospital Midtown | Atlanta | Egyesült Államok | Ismeretlen állapot |
| Rush-Copley Medical Center | Aurora | Egyesült Államok | Ismeretlen állapot |
| UCHealth University of Colorado Hospital | Aurora | Egyesült Államok | Ismeretlen állapot |
| Mercy Oncology and Hematology - Clayton-Clarkson | Ballwin | Egyesült Államok | Ismeretlen állapot |
| Johns Hopkins University/Sidney Kimmel Cancer Center | Baltimore | Egyesült Államok | Ismeretlen állapot |
| Central Care Cancer Center - Bolivar | Bolivar | Egyesült Államok | Ismeretlen állapot |
| McFarland Clinic - Boone | Boone | Egyesült Államok | Ismeretlen állapot |
| Massachusetts General Hospital Cancer Center | Boston | Egyesült Államok | Ismeretlen állapot |
| Dana-Farber Cancer Institute | Boston | Egyesült Államok | Ismeretlen állapot |
| Roswell Park Cancer Institute | Buffalo | Egyesült Államok | Ismeretlen állapot |
| Minnesota Oncology - Burnsville | Burnsville | Egyesült Államok | Ismeretlen állapot |
| Fairview Ridges Hospital | Burnsville | Egyesült Államok | Ismeretlen állapot |
| Cambridge Medical Center | Cambridge | Egyesült Államok | Ismeretlen állapot |
| UNC Lineberger Comprehensive Cancer Center | Chapel Hill | Egyesült Államok | Ismeretlen állapot |
| Carolinas Medical Center/Levine Cancer Institute | Charlotte | Egyesült Államok | Ismeretlen állapot |
| Atrium Health Pineville/LCI-Pineville | Charlotte | Egyesült Államok | Ismeretlen állapot |
| Rush MD Anderson Cancer Center | Chicago | Egyesült Államok | Ismeretlen állapot |
| University of Chicago Comprehensive Cancer Center | Chicago | Egyesült Államok | Ismeretlen állapot |
| Northwestern University | Chicago | Egyesült Államok | Ismeretlen állapot |
| Siteman Cancer Center at Saint Peters Hospital | City of Saint Peters | Egyesült Államok | Ismeretlen állapot |
| Ohio State University Comprehensive Cancer Center | Columbus | Egyesült Államok | Ismeretlen állapot |
| Mercy Hospital | Coon Rapids | Egyesült Államok | Ismeretlen állapot |
| Siteman Cancer Center at West County Hospital | Creve Coeur | Egyesült Államok | Ismeretlen állapot |
| Carle at The Riverfront | Danville | Egyesült Államok | Ismeretlen állapot |
| Northwestern Medicine Cancer Center Kishwaukee | DeKalb | Egyesült Államok | Ismeretlen állapot |
| Smilow Cancer Hospital-Derby Care Center | Derby | Egyesült Államok | Ismeretlen állapot |
| City of Hope Comprehensive Cancer Center | Duarte | Egyesült Államok | Ismeretlen állapot |
| Duke University Medical Center | Durham | Egyesült Államok | Ismeretlen állapot |
| Marshfield Medical Center-EC Cancer Center | Eau Claire | Egyesült Államok | Ismeretlen állapot |
| Fairview Southdale Hospital | Edina | Egyesült Államok | Ismeretlen állapot |
| Carle Physician Group-Effingham | Effingham | Egyesült Államok | Ismeretlen állapot |
| NorthShore University HealthSystem-Evanston Hospital | Evanston | Egyesült Államok | Ismeretlen állapot |
| The Queen's Medical Center - West Oahu | ‘Ewa Beach | Egyesült Államok | Ismeretlen állapot |
| Smilow Cancer Hospital Care Center-Fairfield | Fairfield | Egyesült Államok | Ismeretlen állapot |
| McFarland Clinic - Trinity Cancer Center | Fort Dodge | Egyesült Államok | Ismeretlen állapot |
| Mercy Hospital Fort Smith | Fort Smith | Egyesült Államok | Ismeretlen állapot |
| Parkview Regional Medical Center | Fort Wayne | Egyesült Államok | Ismeretlen állapot |
| Vanderbilt-Ingram Cancer Center Cool Springs | Franklin | Egyesült Államok | Ismeretlen állapot |
| Unity Hospital | Fridley | Egyesült Államok | Ismeretlen állapot |
| Gibbs Cancer Center-Gaffney | Gaffney | Egyesült Államok | Ismeretlen állapot |
| UF Health Cancer Institute - Gainesville | Gainesville | Egyesült Államok | Ismeretlen állapot |
| Central Care Cancer Center - Garden City | Garden City | Egyesült Államok | Ismeretlen állapot |
| Northwestern Medicine Cancer Center Delnor | Geneva | Egyesült Államok | Ismeretlen állapot |
| Smilow Cancer Hospital Care Center at Glastonbury | Glastonbury | Egyesült Államok | Ismeretlen állapot |
| NorthShore University HealthSystem-Glenbrook Hospital | Glenview | Egyesült Államok | Ismeretlen állapot |
| Central Care Cancer Center - Great Bend | Great Bend | Egyesült Államok | Ismeretlen állapot |
| Smilow Cancer Hospital Care Center at Greenwich | Greenwich | Egyesült Államok | Ismeretlen állapot |
| Gibbs Cancer Center-Pelham | Greer | Egyesült Államok | Ismeretlen állapot |
| Smilow Cancer Hospital Care Center - Guilford | Guilford | Egyesült Államok | Ismeretlen állapot |
| Hackensack University Medical Center | Hackensack | Egyesült Államok | Ismeretlen állapot |
| Smilow Cancer Hospital Care Center at Saint Francis | Hartford | Egyesült Államok | Ismeretlen állapot |
| NorthShore University HealthSystem-Highland Park Hospital | Highland Park | Egyesült Államok | Ismeretlen állapot |
| Island Urology | Honolulu | Egyesült Államok | Ismeretlen állapot |
| Hawaii Cancer Care Inc - Waterfront Plaza | Honolulu | Egyesült Államok | Ismeretlen állapot |
| Queen's Medical Center | Honolulu | Egyesült Államok | Ismeretlen állapot |
| Queen's Cancer Cenrer - POB I | Honolulu | Egyesült Államok | Ismeretlen állapot |
| Kapiolani Medical Center for Women and Children | Honolulu | Egyesült Államok | Ismeretlen állapot |
| University of Hawaii Cancer Center | Honolulu | Egyesült Államok | Ismeretlen állapot |
| The Cancer Center of Hawaii-Liliha | Honolulu | Egyesült Államok | Ismeretlen állapot |
| Straub Clinic and Hospital | Honolulu | Egyesült Államok | Ismeretlen állapot |
| Hawaii Diagnostic Radiology Services LLC | Honolulu | Egyesült Államok | Ismeretlen állapot |
| Queen's Cancer Center - Kuakini | Honolulu | Egyesült Államok | Ismeretlen állapot |
| Hawaii Cancer Care Inc-Liliha | Honolulu | Egyesült Államok | Ismeretlen állapot |
| Kuakini Medical Center | Honolulu | Egyesült Államok | Ismeretlen állapot |
| Mayo Clinic in Florida | Jacksonville | Egyesült Államok | Ismeretlen állapot |
| McFarland Clinic - Jefferson | Jefferson | Egyesült Államok | Ismeretlen állapot |
| Mercy Hospital Joplin | Joplin | Egyesült Államok | Ismeretlen állapot |
| Freeman Health System | Joplin | Egyesült Államok | Ismeretlen állapot |
| Straub Medical Center - Kahului Clinic | Kahului | Egyesült Államok | Ismeretlen állapot |
| Castle Medical Center | Kailua | Egyesült Államok | Ismeretlen állapot |
| Northwestern Medicine Lake Forest Hospital | Lake Forest | Egyesült Államok | Ismeretlen állapot |
| Northwell Health/Center for Advanced Medicine | Lake Success | Egyesült Államok | Ismeretlen állapot |
| Cancer Centers of Southwest Oklahoma Research | Lawton | Egyesült Államok | Ismeretlen állapot |
| Wilcox Memorial Hospital and Kauai Medical Clinic | Lihue | Egyesült Államok | Ismeretlen állapot |
| Fairview Clinics and Surgery Center Maple Grove | Maple Grove | Egyesült Államok | Ismeretlen állapot |
| Saint John's Hospital - Healtheast | Maplewood | Egyesült Államok | Ismeretlen állapot |
| Minnesota Oncology Hematology PA-Maplewood | Maplewood | Egyesült Államok | Ismeretlen állapot |
| McFarland Clinic - Marshalltown | Marshalltown | Egyesült Államok | Ismeretlen állapot |
| Marshfield Medical Center-Marshfield | Marshfield | Egyesült Államok | Ismeretlen állapot |
| Carle Physician Group-Mattoon/Charleston | Mattoon | Egyesült Államok | Ismeretlen állapot |
| Medical College of Wisconsin | Milwaukee | Egyesült Államok | Ismeretlen állapot |
| Health Partners Inc | Minneapolis | Egyesült Államok | Ismeretlen állapot |
| Abbott-Northwestern Hospital | Minneapolis | Egyesült Államok | Ismeretlen állapot |
| Hennepin County Medical Center | Minneapolis | Egyesült Államok | Ismeretlen állapot |
| Marshfield Medical Center - Minocqua | Minocqua | Egyesült Államok | Ismeretlen állapot |
| UPMC Hillman Cancer Center - Monroeville | Monroeville | Egyesült Államok | Ismeretlen állapot |
| Monticello Cancer Center | Monticello | Egyesült Államok | Ismeretlen állapot |
| SSM Health Good Samaritan | Mount Vernon | Egyesült Államok | Ismeretlen állapot |
| Vanderbilt Breast Center at One Hundred Oaks | Nashville | Egyesült Államok | Ismeretlen állapot |
| Vanderbilt University/Ingram Cancer Center | Nashville | Egyesült Államok | Ismeretlen állapot |
| Yale University | New Haven | Egyesült Államok | Ismeretlen állapot |
| Cancer Center of Western Wisconsin | New Richmond | Egyesült Államok | Ismeretlen állapot |
| New Ulm Medical Center | New Ulm | Egyesült Államok | Ismeretlen állapot |
| NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center | New York | Egyesült Államok | Ismeretlen állapot |
| Memorial Sloan-Kettering Cancer Center | New York | Egyesült Államok | Ismeretlen állapot |
| Yale-New Haven Hospital North Haven Medical Center | North Haven | Egyesült Államok | Ismeretlen állapot |
| Mercy Hospital Oklahoma City | Oklahoma City | Egyesült Államok | Ismeretlen állapot |
| University of Oklahoma Health Sciences Center | Oklahoma City | Egyesült Államok | Ismeretlen állapot |
| Nebraska Methodist Hospital | Omaha | Egyesült Államok | Ismeretlen állapot |
| Smilow Cancer Hospital-Orange Care Center | Orange | Egyesült Államok | Ismeretlen állapot |
| Thomas Jefferson University Hospital | Philadelphia | Egyesült Államok | Ismeretlen állapot |
| Fox Chase Cancer Center | Philadelphia | Egyesült Államok | Ismeretlen állapot |
| Mayo Clinic Hospital in Arizona | Phoenix | Egyesült Államok | Ismeretlen állapot |
| UPMC-Saint Margaret | Pittsburgh | Egyesült Államok | Ismeretlen állapot |
| UPMC Hillman Cancer Center | Pittsburgh | Egyesült Államok | Ismeretlen állapot |
| Oregon Health and Science University | Portland | Egyesült Államok | Ismeretlen állapot |
| Fairview Northland Medical Center | Princeton | Egyesült Államok | Ismeretlen állapot |
| Marshfield Medical Center-Rice Lake | Rice Lake | Egyesült Államok | Ismeretlen állapot |
| VCU Massey Comprehensive Cancer Center | Richmond | Egyesült Államok | Ismeretlen állapot |
| North Memorial Medical Health Center | Robbinsdale | Egyesült Államok | Ismeretlen állapot |
| Mayo Clinic in Rochester | Rochester | Egyesült Államok | Ismeretlen állapot |
| Phelps Health Delbert Day Cancer Institute | Rolla | Egyesült Államok | Ismeretlen állapot |
| Mercy Clinic-Rolla-Cancer and Hematology | Rolla | Egyesült Államok | Ismeretlen állapot |
| Heartland Regional Medical Center | Saint Joseph | Egyesült Államok | Ismeretlen állapot |
| Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Egyesült Államok | Ismeretlen állapot |
| United Hospital | Saint Paul | Egyesült Államok | Ismeretlen állapot |
| Regions Hospital | Saint Paul | Egyesült Államok | Ismeretlen állapot |
| Huntsman Cancer Institute/University of Utah | Salt Lake City | Egyesült Államok | Ismeretlen állapot |
| University of Utah Sugarhouse Health Center | Salt Lake City | Egyesült Államok | Ismeretlen állapot |
| Mayo Clinic in Arizona | Scottsdale | Egyesült Államok | Ismeretlen állapot |
| Fred Hutchinson Cancer Center | Seattle | Egyesült Államok | Ismeretlen állapot |
| University of Washington Medical Center - Montlake | Seattle | Egyesült Államok | Ismeretlen állapot |
| Saint Francis Regional Medical Center | Shakopee | Egyesült Államok | Ismeretlen állapot |
| LSU Health Sciences Center at Shreveport | Shreveport | Egyesült Államok | Ismeretlen állapot |
| Spartanburg Medical Center | Spartanburg | Egyesült Államok | Ismeretlen állapot |
| Spartanburg Medical Center - Mary Black Campus | Spartanburg | Egyesült Államok | Ismeretlen állapot |
| North Grove Medical Park | Spartanburg | Egyesült Államok | Ismeretlen állapot |
| Mercy Hospital Springfield | Springfield | Egyesült Államok | Ismeretlen állapot |
| CoxHealth South Hospital | Springfield | Egyesült Államok | Ismeretlen állapot |
| Marshfield Medical Center-River Region at Stevens Point | Stevens Point | Egyesült Államok | Ismeretlen állapot |
| Lakeview Hospital | Stillwater | Egyesült Államok | Ismeretlen állapot |
| Mercy Hospital South | St Louis | Egyesült Államok | Ismeretlen állapot |
| Washington University School of Medicine | St Louis | Egyesült Államok | Ismeretlen állapot |
| Siteman Cancer Center at Christian Hospital | St Louis | Egyesült Államok | Ismeretlen állapot |
| Mercy Hospital Saint Louis | St Louis | Egyesült Államok | Ismeretlen állapot |
| Siteman Cancer Center-South County | St Louis | Egyesült Államok | Ismeretlen állapot |
| Mercy Infusion Center - Chippewa | St Louis | Egyesült Államok | Ismeretlen állapot |
| Moffitt Cancer Center | Tampa | Egyesült Államok | Ismeretlen állapot |
| Moffitt Cancer Center - McKinley Campus | Tampa | Egyesült Államok | Ismeretlen állapot |
| Moffitt Cancer Center-International Plaza | Tampa | Egyesült Államok | Ismeretlen állapot |
| Smilow Cancer Hospital-Torrington Care Center | Torrington | Egyesült Államok | Ismeretlen állapot |
| Smilow Cancer Hospital Care Center-Trumbull | Trumbull | Egyesült Államok | Ismeretlen állapot |
| University of Arizona Cancer Center-North Campus | Tucson | Egyesült Államok | Ismeretlen állapot |
| Banner University Medical Center - Tucson | Tucson | Egyesült Államok | Ismeretlen állapot |
| University of Arizona Cancer Center-Orange Grove Campus | Tucson | Egyesült Államok | Ismeretlen állapot |
| SMC Center for Hematology Oncology Union | Union | Egyesült Államok | Ismeretlen állapot |
| The Carle Foundation Hospital | Urbana | Egyesült Államok | Ismeretlen állapot |
| Carle Cancer Center | Urbana | Egyesült Államok | Ismeretlen állapot |
| Ridgeview Medical Center | Waconia | Egyesült Államok | Ismeretlen állapot |
| Northwestern Medicine Cancer Center Warrenville | Warrenville | Egyesült Államok | Ismeretlen állapot |
| Mercy Hospital Washington | Washington | Egyesült Államok | Ismeretlen állapot |
| Sibley Memorial Hospital | Washington D.C. | Egyesült Államok | Ismeretlen állapot |
| Smilow Cancer Hospital-Waterbury Care Center | Waterbury | Egyesült Államok | Ismeretlen állapot |
| Smilow Cancer Hospital Care Center - Waterford | Waterford | Egyesült Államok | Ismeretlen állapot |
| Smilow Cancer Hospital Care Center - Westerly | Westerly | Egyesült Államok | Ismeretlen állapot |
| Marshfield Medical Center - Weston | Weston | Egyesült Államok | Ismeretlen állapot |
| Divine Providence Hospital | Williamsport | Egyesült Államok | Ismeretlen állapot |
| UPMC Susquehanna | Williamsport | Egyesült Államok | Ismeretlen állapot |
| Rice Memorial Hospital | Willmar | Egyesült Államok | Ismeretlen állapot |
| Minnesota Oncology Hematology PA-Woodbury | Woodbury | Egyesült Államok | Ismeretlen állapot |
| Fairview Lakes Medical Center | Wyoming | Egyesült Államok | Ismeretlen állapot |
| Rush-Copley Healthcare Center | Yorkville | Egyesült Államok | Ismeretlen állapot |
Ez az oldal tájékoztatás, nem orvosi tanács. Bármely vizsgálatról az orvosoddal beszélj.