Effects of Vagal Dysfunction on Gastrointestinal and Inflammatory Pathways in HIV

Más betegség

• Known or suspected obstructive disease of the GI tract (e.g. bezoar, strictures, fistulae, physiologic GI obstruction)
• GI surgery within 3m, Crohn's disease, diverticulitis, any electromechanical medical device (e.g. pacemaker, infusion pump).
• Contraindication to pyridostigmine (e.g. mechanical intestinal or urinary obstruction, hypersensitivity to pyridostigmine, cardiac arrhythmias, asthma, chronic obstructive pulmonary disease); use of pyridostigmine within the past 6m.
• History of intracranial aneurysm/hemorrhage, brain tumor, abnormal neck anatomy, or implants or metal hardware near site of stimulation; exposure to VNS within the past 6m.

Egyéb

• Dysphagia to food or pills

• Greater than or equal to18 years old (18 to 64 Years, 65 Years and Over)
• Documentation of HIV-1 infection
• Stable CART for greater or equal to 3 months
• HIV-1 viral load <100 copies/ml (within 3m)
• No diagnosis known to cause autonomic or GI dysfunction other than HIV (e.g. Parkinson's disease, diabetes, peptic ulcer disease, infectious diarrhea)
• Willing to refrain from nicotine use for 24h prior to all testing
• No contraindication to autonomic testing (e.g. uncontrolled glaucoma, heart rate not under sinus control)
• No medications with significant autonomic or GI effects (e.g. sympathomimetics, prokinetics, anti-diarrheals, antibiotics)
• Urine test negative for stimulants and opiates/opioids and pregnancy test (if applicable)