NCT04419649Toboroz2. fázis

A Study of Elritercept to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS)

A Phase 2, Open-Label, Ascending Dose Study of KER-050 for the Treatment of Anemia in Patients With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS)

Forrás: ClinicalTrials.gov · Utoljára frissítve: 2026. okt. 19.

Rövid összefoglaló (regiszter, angolul)

The main aim of this study is to learn how safe elritercept is and how well adults with anemia associated with lower-risk MDS tolerate treatment with different doses of elritercept. Other aims are to learn how safe elritercept is by looking at how many participants have MDS that worsens during the study and learn about the effects of elritercept on anemia linked to MDS. The study will also look to learn how elritercept affects the production of healthy RBCs.

Állapot (regiszter): Toboroz
Fázis (regiszter): 2. fázis
Vizsgálattípus: Beavatkozással járó
Résztvevők száma: 210 (tervezett)
Első benyújtás: 2020. jún. 3.
Kezdés: 2020. aug. 19.
Elsődleges befejezés: 2029. okt. 30.
Fő szponzor: Takeda
Betegségek: Mielodiszplasztikus szindróma (MDS)
NCT-szám: NCT04419649
EU CT-szám: 2023-507469-24-00
EudraCT-szám: 2021-001838-19

Mit vállalsz

Vizsgálat típusa: Beavatkozással járó · 2. fázis
Tervezett résztvevők: 210
2020. aug. 19. és az elsődleges befejezés (2029. okt. 30.) között
45 helyszín, 8 országban
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Ability to understand the purpose and risks of the study and provide signed and dated informed consent and authorization to use protected health information in accordance with national and local study participant privacy regulations.
Male or female ≥ 18 years of age, at the time of signing informed consent.
Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2 (if related to anemia).
Females of childbearing potential and sexually active males must agree to use highly effective methods of contraception.
In the opinion of the Investigator, the participant is able and willing to comply with the requirements of the protocol (e.g., all study procedures, return for follow-up visits).
- Part 1 Inclusion Criteria
- Participants are eligible to be included in Part 1 of the study only if all the following criteria apply:
Diagnosis of MDS according to WHO classification that meets International Prognostic Scoring System-Revised (IPSS-R) classification of very low, low, or intermediate risk disease.
Less than (\<)5 percent (%) blasts in bone marrow during the Pretreatment Period.
Peripheral blood white blood cell (WBC) count \<13,000/microliter (μL) during the Pretreatment Period.
Anemia defined as:
- In non-transfused participants, having received no RBC transfusions within 8 weeks, Hgb concentration ≤ 10.0 g/dL during the Pretreatment Period. OR
- In LTB participants, having received 1 to 3 units of RBCs for Hgb ≤ 9.0 g/dL within 8 weeks of the Pretreatment Period. OR
- In HTB participants, having received ≥ 4 units of RBCs for Hgb ≤ 9.0 g/dL within 8 weeks of the Pretreatment Period.
- Part 1 Extension - Abbreviated Inclusion Criteria
- Participants from Part 1 are eligible to be included in Part 1 Extension of the study only if all the following criteria apply:
Previously completed 4 cycles of elritercept in Part 1 with no dose-limiting toxicities (DLTs).
Participant has the potential to benefit from administration of elritercept, in the opinion of the Investigator.
\< 5% blasts in bone marrow.
Peripheral WBC count \< 13,000/μL during the 28 days prior to cycle 5 day 1 (C5D1).
- Part 2 Inclusion Criteria
- Participants are eligible to be included in Part 2 of the study only if all the following criteria apply:
Cohort A:
- Diagnosis of MDS according to WHO 2016 classification that meets IPSS-R classification of very low, low, or intermediate risk disease.
- ring sideroblast (RS)-positive as defined by WHO 2016 criteria.
- Requiring at least 2 units of RBC transfusions in the preceding 8 weeks before cycle 1 day 1 (C1D1).
Cohort B:
- Diagnosis of MDS according to WHO 2016 classification that meets IPSS-R classification of very low, low, or intermediate risk disease.
- Non-RS as defined by WHO 2016 criteria.
- Requiring at least 2 units of RBC transfusions in the 8 weeks before C1D1.
Cohort C:
- Diagnosis of MDS according to WHO 2016 classification that meets IPSS-R classification of very low, low, or intermediate risk disease.
- Has anemia, defined by Hgb ≤ 10 g/dL during the Pretreatment Period, and received no RBC transfusion in the 8 weeks before C1D1.
Cohort D:
- Diagnosis of CMML according to WHO 2016 classification.
- Has anemia, defined by Hgb ≤ 10 g/dL during the Pretreatment Period, and received no RBC transfusion in the 8 weeks before C1D1. OR
- Received at least 2 units of RBC transfusions for anemia in the 8 weeks before C1D1.
Cohort E:
- Diagnosis of MDS according to WHO 2016 classification that meets IPSS-R classification of very low, low, or intermediate risk disease.
- Requiring ≥ 2 units of RBC transfusions in the preceding 8 weeks before C1D1.
- Receipt of ≥ 20 units of RBC in transfusion over the participant's lifetime.
- Serum ferritin \> 1000 nanograms per milliliter (ng/mL) on ≥ 2 assessments in the preceding 8 weeks before C1D1.
- Treated with stable dose of iron chelation therapy for ≥ 8 weeks prior to C1D1.
Cohort F:
- Diagnosis of MDS according to WHO 2016 classification that meets IPSS-R classification of very low, low, or intermediate risk disease.
- Requiring ≥ 2 units of RBC transfusions in the preceding 8 weeks before C1D1.
- Receipt of ≥ 20 units of RBC in transfusion over the participant's lifetime.
- Serum ferritin \> 1000 ng/mL on ≥ 2 assessments in the preceding 8 weeks before C1D1.
- Not treated with iron chelation therapy in the preceding 8 weeks before C1D1 and not eligible to initiate iron chelation therapy in the opinion of the Investigator and in accordance with local treatment guidelines for initiation of iron chelation therapy.
Cohort G:
- Diagnosis of MDS according to WHO 2016 classification that meets IPSS-R classification of very low, low, or intermediate risk disease.
- RS-positive as defined by WHO 2016 criteria OR non-RS as defined by WHO 2016 criteria.
- Relapsed, refractory, or intolerant to luspatercept treatment
- Relapsed is defined as documentation of response to luspatercept therapy followed by subsequent development of a need for transfusion(s), whether the transfusion need develops during luspatercept treatment or after luspatercept has been discontinued.
- Refractory is defined as documentation of no response with luspatercept ≥ 1 mg/kg administered for ≥ 12 weeks duration.
- Intolerant is defined as documentation of discontinuation of luspatercept therapy due to intolerance including, discontinuation because of any adverse event (serious or nonserious) at any time after treatment initiation.
- Has anemia, defined as either of the following:
- Has received at least 1 unit of RBC transfusions for anemia in the 8 weeks before C1D1; OR
- Hgb ≤ 10 g/dL, and received no RBC transfusion in the 8 weeks before C1D1
- Erythropoietin (EPO) \< 500 international units per liter (U/L) at Baseline.
- Last dose of luspatercept is ≥ 3 weeks from C1D1.
\< 5% blasts in bone marrow assessed by bone marrow aspirate during the Pretreatment Period.
- Part 1 Exclusion Criteria
- Participants are excluded from Part 1 of the study if any of the following criteria apply.
- Medical History
Diagnosis of MDS with deletion of chromosome 5q (Del5q).
Active infection requiring parenteral antibiotic therapy within 28 days prior to C1D1 or oral antibiotics within 14 days of C1D1. Prophylactic antibiotics and/or antifungals for neutropenia are allowed.
Presence of uncontrolled heart disease or New York Heart Association (NYHA) Class III or IV heart failure.
History of drug or alcohol abuse (as defined by the Investigator) within the past 2 years.
History of stroke, deep venous thrombosis (DVT), or arterial embolism within 6 months prior to C1D1.
Major surgery within 28 days prior to C1D1. Participants must be completely recovered from any previous surgery prior to C1D1.
Known positive for human immunodeficiency virus (HIV), active infectious hepatitis B virus (HBV), or active infectious hepatitis C virus (HCV). Participants without known positive history of HIV, HBV, and/or HCV do not require further testing, unless testing is mandated per local guidelines.
Any malignancy other than MDS that has not been in remission and/or has required systemic therapy including radiation, chemotherapy, hormonal therapy, or surgery, within 1 year prior to C1D1. Diagnosis of secondary MDS (i.e., MDS known to have arisen as the result of chemical injury or treatment with chemotherapy and/or radiation for other diseases).
History of solid organ or hematological transplantation.
Presence of uncontrolled hypertension, defined as systolic blood pressure (BP) ≥ 150 mmHg or diastolic BP ≥ 100 mmHg despite adequate treatment.
Body mass index (BMI) ≥ 40 kilograms per meter square (kg/m\^2) during the Pretreatment Period.
History of severe allergic or anaphylactic reaction(s) or hypersensitivity to recombinant proteins or excipients in the investigational medicinal product (IMP).
- Treatment History
Prior treatment with azacitidine, decitabine, lenalidomide, luspatercept, or sotatercept.
Treatment with ESA within 56 days prior to C1D1.
Prior or concurrent chronic treatment with granulocyte colony-stimulating factor (G-CSF) or granulocyte-macrophage colony-stimulating factor (GM-CSF).
Iron chelation therapy if initiated within 8 weeks prior to C1D1.
Vitamin B12 therapy initiated within 8 weeks prior to C1D1. Participants on stable replacement doses for ≥ 8 weeks and without concurrent vitamin B12 or folate deficiency are allowed.
Treatment with another investigational drug or device or approved therapy for investigational use ≤ 28 days prior to C1D1, or, if the half-life of the previous product is known, within 5 times the half-life prior to C1D1, whichever is longer.
- Laboratory Exclusions (during Pretreatment Period)
Platelet count \> 450 ✕ 10\^9/L or \< 30 ✕ 10\^9/L.
Transferrin saturation \< 15%.
Ferritin \< 50 nanograms per milliliter (ng/mL).
Folate \< 4.5 nanomoles per liter (nmol/L) (\< 2.0 ng/mL).
Vitamin B12 \< 148 picomoles per liter (pmol/L) (\< 200 picograms per milliliter \[pg/mL\]).
Estimated glomerular filtration rate (GFR) \< 30 milliliter per minute per 1.73 meter square (mL/min/1.73 m\^2), as determined by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation.
Positive for HIV.
- Miscellaneous
Pregnant or lactating females.
Any other condition not specifically noted above which, in the opinion of the Investigator, would preclude the participant from participating in the study.
Participants who are investigational site staff members directly involved in the conduct of the trial and their immediate family members, site staff members otherwise supervised by the Investigator, or participants who are Sponsor or contract research organization (CRO) employees directly involved in the conduct of the study. Immediate family is defined as a spouse, parent, child, or sibling, whether biological or legally adopted.
- Part 1 Extension - Exclusion Criteria
- Participants from Part 1 are excluded from Part 1 Extension of the study if any of the following criteria apply.
- Medical History
Discontinuation of IMP in Part 1 for any reason.
Has not completed a study visit in the past 12 months.
Active infection requiring parenteral antibiotic therapy within 28 days prior to C5D1 or oral antibiotics within 14 days of C5D1. Prophylactic antibiotics and/or antifungals for neutropenia are allowed.
Presence of uncontrolled heart disease or NYHA Class III or IV heart failure.
History of drug or alcohol abuse (as defined by the Investigator) within the past 2 years.
History of stroke, DVT, or arterial embolism within 6 months prior to C5D1.
Major surgery within 28 days prior to C5D1. Participants must be completely recovered from any previous surgery prior to C5D1.
Known positive for HIV, active infectious HBV, or active infectious HCV. Participants without known positive history of HIV, HBV, and/or HCV do not require further testing, unless testing is mandated per local guidelines.
Any malignancy other than MDS that has not been in remission and/or has required systemic therapy including radiation, chemotherapy, hormonal therapy, or surgery, within 1 year prior to C5D1.
History of solid organ or hematological transplantation.
Presence of uncontrolled hypertension, defined as systolic BP ≥ 150 mmHg or diastolic BP ≥ 100 mmHg despite adequate treatment.
BMI ≥ 40 kg/m\^2 during the 28 days prior to C5D1.
- Treatment History
Prior treatment with azacitidine, decitabine, lenalidomide, luspatercept, or sotatercept.
Treatment with ESA within 56 days prior to C5D1.
Prior or concurrent chronic treatment with G-CSF or GM-CSF.
Iron chelation therapy if initiated within 8 weeks prior to C5D1.
Vitamin B12 with treatment initiated within 8 weeks prior to C5D1. Participants on stable replacement doses for ≥ 8 weeks and without concurrent vitamin B12 or folate deficiency are allowed.
Treatment with another investigational drug or device or approved therapy for investigational use ≤ 28 days prior to C5D1, or, if the half-life of the previous product is known, within 5 times the half-life prior to C5D1, whichever is longer. Previous treatment with elritercept is acceptable.
- Laboratory Exclusions (during Abbreviated Pretreatment Period)
Platelet count \> 450 × 10\^9/L or \< 30 × 10\^9/L.
Transferrin saturation \< 15%.
Ferritin \< 50 ng/mL.
Folate \< 4.5 nmol/L (\< 2.0 ng/mL).
Vitamin B12 \< 148 pmol/L (\< 200 pg/mL).
Estimated GFR \< 30 mL/min/1.73 m\^2, as determined by the CKD-EPI equation.
- Miscellaneous
Pregnant or lactating females.
Any other condition not specifically noted above which, in the opinion of the Investigator, would preclude the participant from participating in the study.
Participants who are investigational site staff members directly involved in the conduct of the trial and their immediate family members, site staff members otherwise supervised by the Investigator, or participants who are Sponsor or CRO employees directly involved in the conduct of the study. Immediate family is defined as a spouse, parent, child, or sibling, whether biological or legally adopted.
- Part 2 Exclusion Criteria
- Participants are excluded from Part 2 of the study if any of the following criteria apply.
- Medical History
Diagnosis of MDS with Del5q.
Diagnosis of secondary MDS (i.e., MDS known to have arisen as the result of chemical injury or treatment with chemotherapy and/or radiation for other diseases).
Active infection requiring parenteral antibiotic therapy within 28 days prior to C1D1 or oral antibiotics within 14 days of C1D1. Prophylactic antibiotics and/or antifungals for neutropenia are allowed.
Presence of the following cardiac conditions:
- Presence of uncontrolled heart disease or NYHA Class III or IV heart failure.
- QTcF (QT interval corrected by Fridericia's formula) \> 500 msec on the screening or C1D1 electrocardiogram (ECG; mean of 3 measurements).
- Uncontrolled clinically significant arrhythmia (participants with rate-controlled atrial fibrillation are not excluded).
- Acute myocardial infarction or unstable angina pectoris ≤ 6 months prior to C1D1.
Presence of uncontrolled hypertension, defined as systolic BP ≥ 160 mmHg or diastolic BP ≥ 100 mmHg despite adequate treatment.
History of stroke, DVT, or arterial embolism within 6 months prior to C1D1.
History of drug or alcohol abuse (as defined by the Investigator) within the past 2 years.
Major surgery within 28 days prior to C1D1. Participants must be completely recovered from any previous surgery prior to C1D1.
Any malignancy other than MDS or CMML that has not been in remission and/or has required major surgery or systemic therapy including radiation, chemotherapy, targeted therapy, or hormonal therapy within 1 year prior to C1D1.
History of solid organ or hematological transplantation.
Diagnosis of hemolytic anemia, active bleeding, hemoglobinopathies, or congenital disorders as a cause of the participant's anemia.
NCI-CTCAE Grade ≥ 2 bleeding events within the 3 months prior to C1D1.
Receipt of an RBC or platelet transfusion for any reason(s) or combination of reasons other than underlying MDS within the 16 weeks prior to C1D1. If a participant requires a transfusion for an unanticipated reason during the Pretreatment Period, a prolonged screening period may be considered after discussion with the Medical Monitor.
Known positive for HIV, active infectious HBV with positive viral load (HBV DNA), or active infectious HCV with positive viral load (HCV RNA). Participants without known positive history of HIV, HBV, and/or HCV do not require further testing, unless testing is mandated per local guidelines.
BMI ≥ 40 kg/m\^2.
History of severe allergic or anaphylactic reaction(s) or hypersensitivity to recombinant proteins or excipients in the IMP.
Diagnosis of cirrhosis, non-alcoholic steatohepatitis, alcoholic liver disease, hepatitis, or other liver disease (acute or chronic) meeting Child-Pugh C criteria for hepatic impairment. Participants with elevated liver enzymes are allowed if the liver enzyme elevation is suspected to be due to iron-overload or iron chelation, and other hepatic causes have been ruled out, in the opinion of the Investigator.
- Treatment History
Prior treatment with azacitidine, decitabine, lenalidomide, or sotatercept.
Prior treatment with luspatercept (Cohorts A, B, C, D, E, and F only).
Treatment with ESA within 8 weeks prior to C1D1.
Iron chelation therapy if initiated within 8 weeks prior to C1D1. Participants on stable doses of iron chelation therapy for ≥ 8 weeks are allowed.
Vitamin B12 and/or folate therapy initiated within 8 weeks prior to C1D1. Participants on stable replacement doses for ≥ 8 weeks and without concurrent vitamin B12 or folate deficiency are allowed.
Any need to receive a prohibited medication.
Treatment with another investigational drug or device or approved therapy for investigational use within 8 weeks prior to C1D1, or, if the half-life of the previous product is known, within 5 times the half-life prior to C1D1, whichever is longer.
- Laboratory Exclusions (during Pretreatment Period)
Platelet count \> 800 × 10\^9/L or \< 25 × 10\^9/L.
Ferritin \< 50 ng/mL.
Folate \< 4.5 nmol/L (\< 2.0 ng/mL).
Vitamin B12 \< 148 pmol/L (\< 200 pg/mL).
Estimated GFR \< 30 mL/min/1.73 m\^2 as determined by the CKD-EPI equation.
- Miscellaneous
Pregnant or lactating females.
Any other condition not specifically noted above which, in the opinion of the Investigator, would preclude the participant from participating in the study.
Participants who are investigational site staff members directly involved in the conduct of the trial and their immediate family members, site staff members otherwise supervised by the Investigator, or participants who are Sponsor or CRO employees directly involved in the conduct of the study. Immediate family is defined as a spouse, parent, child, or sibling, whether biological or legally adopted.
- For Cohort G ONLY:
Any luspatercept related AE Grade ≥ 3 that has not resolved to baseline or Grade ≤ 1.
History of allergy/anaphylaxis/hypersensitivity to luspatercept.
Prior treatment with imetelstat.

Életkor a regiszterben: 18 év – - · Nem: nők és férfiak · Egészséges önkénteseket nem fogad

A teljes feltétellista: ClinicalTrials.gov

Helyszínek (45)

Helyszínek a regiszter sorrendjében. Ha a profilodba mented a városodat, távolság szerint rendeződnek.

Helyszín	Város	Ország	Helyszín állapota
Royal Adelaide Hospital Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Adelaide	Ausztrália	Toboroz
Border Medical Oncology Research Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Albury	Ausztrália	Toboroz
Flinders Medical Centre Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Bedford Park	Ausztrália	Toboroz
Boxhill Hospital Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Box Hill	Ausztrália	Toboroz
Townsville University Hospital Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Douglas	Ausztrália	Befejeződött
University Hospital Geelong Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Geelong	Ausztrália	Toboroz
Austin Health Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Heidelberg	Ausztrália	Toboroz
St Vincent's Hospital Melbourne Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Melbourne	Ausztrália	Toboroz
Royal Melbourne Hospital Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Melbourne	Ausztrália	Toboroz
Tweed Hospital Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Tweed Heads	Ausztrália	Toboroz
Ballarat Oncology & Haematology Service Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Wendouree	Ausztrália	Befejeződött
Westmead Hospital Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Westmead	Ausztrália	Toboroz
Fakultni nemocnice Kralovske Vinohrady Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Prague	Csehország	Fut, nem toboroz
Klinikum Bayreuth GmbH Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Bayreuth	Németország	Fut, nem toboroz
Charite Universitaetsmedizin Berlin KöR Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Berlin	Németország	Fut, nem toboroz
Praxis am Volkspark Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Berlin	Németország	Fut, nem toboroz
Universitaetsklinikum Bonn AöR Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Bonn	Németország	Fut, nem toboroz
Marien Hospital Duesseldorf GmbH Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Duesseldorf	Németország	Fut, nem toboroz
Klinikum Esslingen GmbH Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Esslingen am Neckar	Németország	Fut, nem toboroz
Martin-Luther-Universitaet Halle-Wittenberg Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Halle (Saale)	Németország	Fut, nem toboroz
Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz KöR Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Mainz	Németország	Fut, nem toboroz
Hospital Universitari Vall d'Hebron Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Barcelona	Spanyolország	Toboroz
Institut Catala D'oncologia Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	L'Hospitalet de Llobregat	Spanyolország	Toboroz
Hospital Universitario Central De Asturias Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Oviedo	Spanyolország	Toboroz
Hospital Universitario De Salamanca Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Salamanca	Spanyolország	Toboroz
Hospital Universitario Y Politecnico La Fe Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Valencia	Spanyolország	Toboroz
Centre Hospitalier Universitaire de Nantes Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Nantes	Franciaország	Toboroz
Centre Hospitalier Universitaire de Nice Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Nice	Franciaország	Toboroz
Hopital Saint Louis Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Paris	Franciaország	Toboroz
Hopital Haut-Leveque Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Pessac	Franciaország	Toboroz
Hôpital NOVO Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Pontoise	Franciaország	Toboroz
Sheba Medical Center - Sheba Fund for Health Services and Research Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Ramat Gan	Izrael	Toboroz
Sourasky Medical Center - Infrastructure and Health Services Fund of the Tel Aviv Medical Center Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Tel Aviv	Izrael	Befejeződött
Middlemore Hospital Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Auckland	Új-Zéland	Befejeződött
The Center for Cancer and Blood Disorders (CCBD) - Bethesda Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Bethesda	Egyesült Államok	Toboroz
City of Hope National Medical Center Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Duarte	Egyesült Államok	Toboroz
Hackensack Medical Center Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Hackensack	Egyesült Államok	Toboroz
Genesis Cancer and Blood Institute Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Hot Springs	Egyesült Államok	Toboroz
Univ of Texas MD Anderson Cancer Center, Division of Cancer Medicine Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Houston	Egyesült Államok	Toboroz
Karmanos Cancer Institute at McLaren Greater Lansing Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Lansing	Egyesült Államok	Befejeződött
Baptist Clinical Research Institute Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Memphis	Egyesült Államok	Toboroz
University of Miami School of Medicine Sylvester Comprehensive Cancer Center (SCCC) Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Miami	Egyesült Államok	Toboroz
University of Pittsburgh Medical Health Center Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Pittsburgh	Egyesült Államok	Befejeződött
New York Cancer and Blood Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Shirley	Egyesült Államok	Toboroz
H. Lee Moffitt Cancer Center and Research Center Ennek a helyszínnek vagy a koordinátora? Erősítsd meg az állapotát	Tampa	Egyesült Államok	Toboroz

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