New IDEAS: Imaging Dementia-Evidence for Amyloid Scanning Study

Korábbi kezelés

• Amyloid status already known to patient or referring clinician based on prior amyloid imaging or cerebrospinal fluid analysis.
• Current or previous enrollment in an anti-amyloid therapeutic trial.
• Hip/pelvic fracture within the 12 months prior to enrollment.

Más betegség

• Knowledge of amyloid status, in the opinion of the referring dementia expert, may cause significant psychological harm or otherwise negatively impact the patient or family.
• Scan is being ordered solely based on a family history of dementia, presence of apolipoprotein E (ApoE) 4, or in lieu of genotyping for suspected autosomal mutation carriers.
• Cancer requiring active therapy (excluding non-melanoma skin cancer).

Egyéb

• Normal cognition or subjective complaints that are not verified by cognitive testing or key informant.
• Scan being ordered for nonmedical purposes (e.g., legal, insurance coverage, or employment screening).
• Body weight exceeds PET scanner weight limit.
• Currently pregnant or planning to become pregnant within 90 days of registration.
• Life expectancy less than 24 months based on medical co-morbidities.
• Residence in a skilled nursing facility (assisted living facility is not an exclusion criterion).

• Medicare beneficiary with Medicare as primary insurance;
• Meets clinical criteria for Mild Cognitive Impairment (MCI) or Dementia as defined by the 2018 National Institute on Aging - Alzheimer's Association Research Framework
• Brain MRI and/or CT within 24 months prior to enrollment;
• Clinical laboratory assessment (complete blood count \[CBC\], standard blood chemistry profile, thyroid stimulating hormone \[TSH\], vitamin B12) within the 12 months prior to enrollment;
• Able to tolerate amyloid PET required by protocol, to be performed at a participating PET facility;
• English or Spanish speaking (for the purposes of informed consent);
• Willing and able to provide consent. Consent may be by proxy;
• Neuropsychiatric syndrome can be classified into "clinically typical" or "clinically atypical" categories