Technology-Enhanced Acceleration of Germline Evaluation for Therapy, TARGET Study

Korábbi kezelés

• Having had prior germline genetic testing for inherited cancer risk (pertains to aim 2)

Más betegség

• Mental or cognitive impairment that interferes with ability to provide informed consent

Életkor

• Age \< 18 years

Egyéb

• Non-English speaking

• AIM 1: Medical oncologists, radiation oncologists and urologists spanning Veterans Affairs (VA), academic, and community settings
• AIM 2: Any English speaking man \>= 18 with PCA who has computer and web-access and meets any one of the following:
  • Metastatic disease
  • T3a or higher
  • Prostate specific antigen (PSA) \> 20
  • Grade group 4 or higher
  • Intraductal or cribriform histology
  • Biochemical recurrence
  • Ashkenazi Jewish ancestry
  • Family history criteria (see below) \*\* Family history: If any one of the following levels are met, the person is eligible:
  • Level 1: \>= 1 close blood relative (first degree relative \[FDR\], second degree relative \[SDR\], third degree relative \[TDR\]) diagnosed with breast cancer =\< age 50 or the following cancers at any age: pancreatic, ovarian, or metastatic or intraductal/cribriform prostate cancer
  • Level 2: \>= 2 close blood relatives (FDR, SDR, TDR) on same side of the family with breast or prostate cancer at any age
  • Level 3: one brother, father, or \>= 2 family members (close blood relatives - FDR, SDR, TDR) on the same side of the family diagnosed with prostate cancer at \< 60
  • Level 4: \>= 3 cancers on the same side of the family (especially if diagnosed =\< 50): bile duct, breast, colorectal, endometrial, gastric, kidney, melanoma, ovarian, pancreatic, prostate (grade groups 2-5 if known), small bowel, or urothelial