NCT04486586Visszavonva
Effects of tDCS on Apraxia of Speech in Non-Fluent Primary Progressive Aphasia
Effects of Transcranial Direct Current Stimulation in Primary Progressive Aphasia (PPA)
Forrás: ClinicalTrials.gov · Utoljára frissítve: 2025. ápr. 24.
Megadott ok: The study was withdrawn due to a shift in research priorities, with the decision made to focus resources on other studies that align more closely with the current strategic goals.
Rövid összefoglaló (regiszter, angolul)
Primary progressive aphasia (PPA) is a neurodegenerative disease that affects first and foremost language abilities. There are three different variants of PPA, each a relatively distinct speech and language profile. For individuals with non-fluent variant PPA (nfvPPA), a core symptom is apraxia of speech (AOS), which is defined as an oral motor speech disorder. Such a disorder inhibits one's ability to translate speech plans into motor plans and results in longer segmental durations and reduced rate of syllabic production. This research project investigates the behavioral and neuromodulatory effects of transcranial direct current stimulation (tDCS) during language therapy in participants with nfvPPA over time. Anodal tDCS targeting the left inferior frontal gyrus (IFG) administered in combination with language therapy is expected to be more beneficial when compared to language therapy alone (sham). The investigators believe tDCS during language therapy will 1) improve language performance or decrease rate of decline, 2) promote better-sustained effects at 2 weeks and 2 months post-treatment, and 3) produce generalization to untrained language items and some other cognitive functions. Resting-state fMRI, diffusion tensor imaging (DTI), and volumetric data are also collected to investigate changes in functional brain connectivity associated with tDCS in individuals with PPA. A better understanding of the therapeutic and neuromodulatory mechanisms of tDCS as an adjunct to language therapy in nfvPPA may have a significant impact on the development of effective therapies for PPA, and may offer insight into ways of impeding neurodegeneration that may improve patients' quality of life, as well as extend patients' ability to work and manage patients' affairs.
- Állapot (regiszter)
- Visszavonva
- Vizsgálattípus
- Beavatkozással járó
- Résztvevők száma
- 0 (tényleges)
- Első benyújtás
- 2020. júl. 20.
- Kezdés
- 2013. ápr.
- Elsődleges befejezés
- 2025. ápr.
- Fő szponzor
- Johns Hopkins University
- Betegségek
- Frontotemporális demencia
- NCT-szám
- NCT04486586
Ki nem vehet részt
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Más betegség
- Uncorrected visual or hearing impairment by self report.
- Stroke/other premorbid neurological disorder affecting the brain.
- Any other language-based learning disorder other than PPA.
- Western Aphasia Battery Aphasia Quotient (AQ) <30 (indicating severe language impairment).
- Cardiac pacemakers or ferromagnetic implants.
Egyéb
- Inability to follow directions for baseline tasks.
- Severe claustrophobia.
- Pregnant women.
Kiket keres a vizsgálat
- Must be clinically diagnosed with nfvPPA or unclassifiable PPA. Diagnosis will be based on neuropsychological testing, language testing (most commonly the Western Aphasia Battery), MRI and clinical assessment.
- Must be right-handed.
- Must be speaker of English.
- Must have at least 9th grade education.
Életkor a regiszterben: 50 év – 90 év · Nem: nők és férfiak · Egészséges önkénteseket is fogad
Helyszínek (1)
Helyszínek a regiszter sorrendjében. Ha a profilodba mented a városodat, távolság szerint rendeződnek.
| Helyszín | Város | Ország | Helyszín állapota |
|---|---|---|---|
| Johns Hopkins Hospital | Baltimore | Egyesült Államok | Ismeretlen állapot |
Ez az oldal tájékoztatás, nem orvosi tanács. Bármely vizsgálatról az orvosoddal beszélj.