A Study to Evaluate Renal Fibrosis Using MRI Techniques

Korábbi kezelés

• Patients have clinically significant medical conditions within the prior six months: e.g. myocardial infarction, congestive heart failure, stroke, that would, in the opinion of the investigators, compromise the safety of the patient.
• Requirement for potentially nephrotoxic drugs; e.g., non-steroidal anti-inflammatory drugs.
• Kidney transplant.

Más betegség

• Uncontrolled hypertension (Systolic BP >180 mmHg despite therapy).
• Diabetes requiring insulin or oral hypoglycemic medications.
• Evidence of hepatitis B or C, or HIV infection.
• History of deep venous thrombosis within 3 months of enrollment.
• Any active malignancy and undergoing therapy
• Another known acute or chronic kidney disease
• Latex allergy

Laborértékek

• Patient has serum creatinine >2.2 mg/dL for men and >2.0 mg/dL for women (Caucasians); >2.4 mg/dL for men and >2.1 mg/dL for women (African American).
• Cardiac ejection fraction less than 30%.

Egyéb

• RVD in a solitary kidney
• Pacemaker, implantable defibrillator or other contraindication to MRI
• Inability to comply with breath-hold for 20 seconds
• Patients are pregnant.
• Kidney or ureteric stone
• Federal medical center inmates.

• Between ages 40 and 80 years old.
• Patients with hypertension (BP>140/90 mmHg) and/or requirement for two or more antihypertensive medications for more than 4 weeks.
• Serum creatinine under 2.2 and 2.0 mg/dL for men and women, respectively (Caucasians). Values for African-American subjects are slightly higher (2.4 mg/dL, males; 2.1 mg/dL females).
• No contraindications to angiography: severe contrast allergy.
• No contraindications to no-contrast MR evaluations: e.g. pacemaker or magnetically active metal fragments, claustrophobia.
• Patients have the ability to comply with protocol
• Patients are competent and able to provide written informed consent