Childhood Cancer Predisposition Study (CCPS)

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• Individuals with a strong personal or family history of cancer without a genetic or clinical diagnosis of a specific CPS are not eligible for enrollment.

• Primary Subjects must meet all of the below criteria to be eligible for enrollment:
• Be less than 21 years of age at the time of enrollment
• Have a diagnosis of a specific CPS, whether they have had cancer or not
  • Based on clinical laboratory testing demonstrating a Pathogenic or Likely Pathogenic germline variant and/or
  • Based on well-established clinical diagnostic criteria and/or
  • Based on high clinical suspicion of a specific CPS with clinical laboratory testing demonstrating a variant of uncertain significance (VUS)
  • Affected Parents must meet all of the following criteria to be eligible for enrollment:
• Be the biologic parent of a Primary Subject and
• Carry a diagnosis (or obligate diagnosis) of the familial CPS
  • Adult Affected Siblings must meet all of the following criteria to be eligible for enrollment:
• Be the biologic sibling of a Primary Subject and
• Carry a diagnosis (or obligate diagnosis) of the familial CPS
  • Unaffected Parents and Siblings must meet all of the following criteria to be eligible for enrollment
• Be the biologic parent or sibling of a Primary Subject and
• Not carry a diagnosis (or obligate diagnosis) of the familial CPS
  • Affected Family Members must meet all of the following criteria to be eligible for enrollment:
• Carry a diagnosis of (or obligate diagnosis of) the familial CPS. Documentation is requested but not required.
  • More than one child from a Primary Family Unit may be a Primary Subject. An Unaffected Sibling may be reclassified as a Primary Subject if diagnosed with a CPS during childhood.