Exercise Therapy and Radiation Therapy (EXERT) for Metastatic Prostate Cancer

Korábbi kezelés

• Performing > 90 minutes/week of exercise therapy prior at time of enrollment
• History of acute coronary syndromes (including myocardial infarction and unstable angina), coronary angioplasty or stenting within the past 6 months prior to the start of radiation therapy
• Uncontrolled arrhythmias; patients with rate-controlled atrial fibrillation for >1 month prior to start of radiation therapy may be eligible
• In-patient receiving radiation therapy for a radiation emergency (e.g. cord compression, Superior vena cava (SVC) syndrome, brain metastases)

Más betegség

• Cardiac exclusion criteria:
• Class II, III or IV heart failure as defined by the New York Heart Association (NYHA) functional classification system
• thrombosis of lower extremities
• respiratory failure
• acute non-cardiopulmonary disorder that may affect exercise performance or be aggravated by exercise
• Mental impairment leading to inability to complete study requirements

Életkor

• Children (the protocol will only include men age 18 and older)

Egyéb

• Evidence in the medical record of an absolute contraindication for exercise
• syncope
• acute myocarditis, pericarditis, or endocarditis
• acute pulmonary embolus or pulmonary infarction
• suspected dissecting aneurysm
• pulmonary edema
• High risk of fracture or spine instability (Mirels score ≥7, SINS ≥7)

• Subjects must have lymph node positive or metastatic disease consistent with prostate cancer
• Males ≥18 years of age receiving RT
• Patient receiving 5 fractions or stereotactic body radiation therapy (SBRT)
• Patient may have received prior hormone therapy. Prior or current use of chemotherapy agents is allowed, but not necessary.
• Fluent in written and spoken English
• Must be able to provide and understand informed consent
• Must have an ECOG Performance Status (PS) of ≤ 3
• Primary attending radiation oncologist approval