Study comparing a metformin treatment to standard care to extend time without diabetes after bariatric surgery

Más betegség

• Known type 1 diabetes

Laborértékek

• Known contraindication to metformin: o Acute metabolic acidosis o Acute affection which could lead to renal deterioration (ex: dehydration, serious infection, shock, intravascular administration of iodinated contrast agent within the last 48 hours) o Acute or chronic disease which could lead to a tissue hypoxia (ex : severe cardiac insufficiency, severe respiratory insufficiency, myocardial infarction within the last 3 months, shock) o Hepatocellular insufficiency o Prothrombin ratio ≤ 50% o SGOT or SGPT levels ≥ 10 times the upper limits of the normal range o Alcohol use disorder
• Medications and medical conditions likely to confound the assessment of diabetes: o glucocorticoids treatment o renal graft o Cushing’s syndrome o acromegaly o fasting plasma triglyceride > 600 mg/dl despite treatment

Egyéb

• Pregnancy and breastfeeding
• Estimated glomerular filtration rate ≤44 ml/min (MDRD)
• Known intolerance to metformin
• Patient under legal protection

• Adults 18-70 years-old
• Having undergone gastric bypass or sleeve gastrectomy 12 to 36 ±3 months before inclusion
• Ex-T2D treated with at least one anti-diabetic drug before bariatric surgery or HbA1c ≥ 6.5% before bariatric surgery
• HbA1C < 6.5 % at inclusion with no anti-hyperglycemic medications for the last three months
• Written consent