Steroid Sparing Treatment With in Newly Diagnosed Transplant Ineligible Patients With Multiple Myeloma

Korábbi kezelés

• Receiving cancer therapy
• Radiation therapy within 14 days of enrollment
• Major surgery within 2 weeks before enrollment

Más betegség

• A diagnosis of Waldenström's disease
• Human immunodeficiency virus -infected patients must be on effective anti-retroviral therapy with undetectable viral load within the past 6 months
• Seropositive for hepatitis B, or seropositive for hepatitis C
• Ongoing systemic bacterial, fungal or viral infection
• Severe and/or uncontrolled medical conditions
• Malignancy within 2 years of study enrollment
• Contraindications to required prophylaxis for deep vein thrombosis and pulmonary embolism.

Egyéb

• A diagnosis of primary amyloidosis; monoclonal gammopathy of undetermined significance, smoldering multiple myeloma; non-secretory myeloma
• Women who are pregnant or lactating

• Diagnosis of multiple myeloma with diagnosis
• Must not have received previous therapy for multiple myeloma
• Newly diagnosed and not considered candidate for high-dose chemotherapy
• Adequate organ system function
• A performance status ≤ 3
• Ability to swallow and retain oral medication
• Female subjects of child bearing potential must be surgically sterile, be post-menopausal