Zanubrutinib Combined With Standard Chemotherapy in the Treatment for Patients With Diffuse Large B Cell Lymphoma

Korábbi kezelés

• Serious surgery and trauma less than two weeks
• Vaccination with live attenuated vaccine less than 4 weeks

Más betegség

• Active malignant tumor need be treated at the same time
• Other malignant tumor history
• Systemic therapy for serious acute/chronic infection
• Congestive heart failure, uncontrolled coronary heart disease, arrhythmia and heart infarction less than 6 months
• HIV-positive, AIDS patients and untreated active hepatitis
• Patients with a history of deep vein thrombosis or pulmonary embolism less than 12 months
• Patients with a history of mental illness

Egyéb

• Diagnosed as high-grade B-cell lymphoma, including non-specified and double-strike or triple-strike
• Diagnosed as grey-zone lymphoma
• Diagnosed as primary mediastinal large B-cell lymphoma
• Diagnosed as CD20 negative diffuse large B-cell lymphoma
• Researchers determine unsuited to participate in this trial

• Age between 18 to 75 years old (including 18 and 75)
• Diagnosed as diffuse large B cell lymphoma
• CD79A/CD79B genetic abnormality
• Subjects with untreated or relapsed/refractory DLBCL
• Having at least one measurable lesions
• World health organization-Eastern Cooperative Oncology Group Performance Status (ECOG) 0-1
• Life expectancy no less than 3 months
• enough main organ function
• Pregnancy test within 7 days must be negative for women of childbearing period, and appropriate measures should be taken for contraception for women in childbearing period during the study and six months after this study
• Agreeing to sign the written informed consents