Study of the Genetic Factors Involved in Autism and Related Disorders

Más betegség

• Probands with Autism Spectrum Disorder
• Personal neurologic history (epilepsy, or severe neurological disease)
  • Relatives of the probands with ASD, of the controls or the controls:
  • ● Medical condition (psychiatric or somatic) not compatible with the inclusion

Életkor

• Severe Intelectual Deficiency (IQ,35 or developmental age \<18 months)
  • ●. Personal psychiatric history (schizophrenia, bipolar disorder, substance use disorder (except tobacco), recurrent depression disorder, severe instable anxiety disorder)

• Probands with Autism Spectrum Disorder
• Meet the diagnostic criteria for ASD of the DSM-5 \[American Psychiatric Association, 2013\] based on a consensus between the clinical expertise of expert clinicians, the scores of the Autism Diagnostic Interview-Revised (ADI-R) (Rutter et al, 2003) and those of the Autism Diagnosis Observation Schedule (ADOS-2) (Lord et al, 2012)
• Be at least 24 months (no upper age limit)
• Somatic and Intellectual state compatible with a blood test
• Affiliation to the social insurance
• Signature of informed consent by the applicant or by holders of parental authority if the subject is a minor or by the guardian if the subject is under guardianship
  • Controls without ASD
• At least 24 months old
• Somatic and Intellectual state compatible with a blood test
• Affiliation to the social insurance
• Signature of informed consent by the subject or by holders of parental authority if the subject is a minor or by the guardian if the subject is under guardianship
  • Relatives of the probands with ASD or of controls without ASD
• At least 24 months old
• Somatic and Intellectual state compatible with a blood test
• Affiliation to the social insurance
• Signature of informed consent by the subject or by holders of parental authority if the subject is a minor or by the guardian if the subject is under guardianship