Video-oculography and Parkinson's Disease

A regiszterben nem jelölt feltételek

• \*Inclusion Criteria:
• Male or Female;
• Clinically defined idiopathic Parkinson's Disease (PD);
• Brain MRI performed in routine care in the 12 months preceding inclusion;
• Cerebral DaTSCAN or cerebral PET with F-DOPA, performed as routine care before inclusion (no time limit), confirming presynaptic dopaminergic denervation;
• Hoehn \& Yahr score: 1 to 3;
• Normal clinical examination of oculomotricity (slight impairment of smooth pursuit accepted);
• Neuro-cognitive disorders: absent or minor (according to DSM5);
• Sufficient written and oral expression in French;
• Covered by a health insurance system;
• Written informed consent signed by the patient;
• Presence of a caregiver.
  • \* Exclusion Criteria:
• Psychiatric comorbidity (except anxiety or mild to moderate depression);
• Neurological comorbidity, if significant;
• Brain MRI showing:
  • significant cerebrovascular pathology (Fazekas I admitted),
  • another brain disease, including stroke.
• Major cognitive impairment;
• Absolute exclusion criteria and "Red flags" of the 2015 criteria orienting towards another degenerative pathology of the extrapyramidal system:
  • Cerebellar syndrome
  • Vertical oculomotricity disorders on clinical examination
  • Motor symptoms restricted to the lower limbs
  • Bilateral and perfectly symmetrical parkinsonism
  • Early dystonia
  • Clinical profile suggestive of behavioral variant frontotemporal dementia (bvFTD)
  • Progressive aphasia or apraxia
  • Moderate or severe postural instability and / or early falls
  • Early bulbar dysfunction (dysarthria, swallowing disorders)
  • Ventilatory dysfunction (inspiration)
  • Severe dysautonomia
  • DOPA-resistance
  • Neuroleptic treatment or related
• Normal MIBG myocardial scintigraphy (if performed).