Defining the Role of the Skin Microbiome in Immune-related Adverse Events
Megadott ok: target number of patients not reached and disabling team changes
Key facts
- Where
- Bordeaux, FranciaországSee the site
Where in Franciaország
- Service de Dermatologie - Hôpital Saint-AndréBordeaux, FranciaországNo longer taking part
Trial details
- Who runs it
- University Hospital, Bordeaux
- Trial code
- NCT04734704
- Record updated
- 2026. június 23.
- Original description
The skin microbiome has been implicated in several cutaneous autoimmune pathologies such as psoriasis and atopic dermatitis. However, its role in vitiligo and vitiligo lesions occuring in patients receiving anti-PD-1 for metastatic melanomaRead full original descriptionShow less
Defining the Role of the Skin Microbiome in Vitiligo and Immune-related Adverse Events in Advanced Melanoma Patients Treated With Anti-PD1
The skin microbiome has been implicated in several cutaneous autoimmune pathologies such as psoriasis and atopic dermatitis. However, its role in vitiligo and vitiligo lesions occuring in patients receiving anti-PD-1 for metastatic melanoma
Inclusion: Adult patients diagnosed with Vitiligo according to usual criteria; Adult patients with metastatic melanoma, under anti-PD-1 who developed vitiligo; Adult patients with metastatic melanoma who did not develop Immune related adverse events under anti-PD-1; Adult patients with metastatic melanoma who developed vitiligo under anti-PD-1 and discontinued the treatment; Free, informed by the participant and the investigator (at the latest on the day of inclusion and before any examination required by the research).
Exclusion: Patients under 18 years old; No treatment for vitiligo in the past 4 weeks; Patients under legal protection or unable to express their consent; Patients not affiliated to a health insurance system; Patients deprived of liberty by judiciary or administrative decision or hospitalized without consent or admitted in a sanitary or social institution for another reason than research.