Regulating Blood Pressure During Recovery From Intracerebral Hemorrhage and Ischemic Stroke

Korábbi kezelés

• Contraindication to discontinuing mineralocorticoid antagonist therapy for 3-12 months per the investigator's discretion (e.g., refractory proteinuria)

Más betegség

• Known hypersensitivity to spironolactone
• Any condition which, in the judgement of the investigator, increases the risk to the patient
• History of Addison's disease

Laborértékek

• eGFR \<45
• Serum potassium greater than or equal to the upper limit of normal of the lab on the two most recent consecutive potassium levels prior to enrollment

Egyéb

• Secondary ICH due to trauma, vascular malformation, or tumor
• Life expectancy \< 1 year
• Upper arm greater than 17 inches in circumference
• Pregnancy, planned pregnancy, or breastfeeding
• Systolic BP \>200 mmHg or diastolic BP \>110 mmHg at the time of randomization
• Systolic BP \<120 mmHg at the time of randomization

• Age ≥ 18 years
• Symptomatic ICH confirmed by head CT or brain MRI during hospitalization OR ischemic stroke patients. Ischemic stroke will be defined by focal signs/symptoms of any duration associated with evidence of acute arterial infarction on neuroimaging or clinical evidence of cerebral focal arterial ischemic injury with symptoms persisting ≥ 24 hours.
• Written, informed consent by patient or surrogate
• Ability to comply with all study procedures and available for the duration of the study