Influence of Oxygen on Perioperative Outcome in Patients Undergoing General Anaesthesia for Elective Non-cardiac Surgery

Korábbi kezelés

• Acute coronary event 30 days before surgery
• Hemodynamic instability before induction of aneasthesia (vasopressor or inotrope infusion since hospitalization for index surgery)
• Scheduled surgery in the thoracic cavity
• Emergency surgery (to be performed within less than 12 hours of scheduling)
• Ambulatory surgery

Más betegség

• Acute congestive heart failure
• Atrial fibrillation or other severe arrhythmia
• Severe pulmonary disease (dependent on oxygen therapy or the Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage 4 or severe carbon monoxide diffusion impairment or severe pulmonary hypertension)
• Increased risk of oxygen toxicity (e.g., chemotherapy for malignancy within 3 months, bleomycin treatment, airway laser surgery)
• Pre-existing surgical site infection (SSI)
• Current active signs of systemic inflammatory response syndrome (SIRS) or sepsis according The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

Egyéb

• Preoperative oxygen saturation (SpO2) below 90% on room air
• ICU admission for respirator weaning and delayed extubation
• Pregnancy
• Baseline hs-TnT level elevated above 65ng/L

• Written informed consent
• Patients eligible for the study should be scheduled for elective or non-emergent non-cardiac vascular surgery under general anaesthesia with endotracheal intubation, and have either
• proven CAD and will undergo high- or intermediate surgical risk procedure according to European (European Society of Cardiology, ESC / European Society of Anaesthesiology and Intensive Care, ESAIC) guidelines on non-cardiac surgery.
  • or
• two or more risk factors for CAD and will undergo high- or intermediate surgical risk procedures according to European ESC/ESAIC guidelines on non-cardiac surgery.