Cohort Study of Airway Microecology and the Pathogenesis and Evolution of Chronic Obstructive Pulmonary Disease

Más betegség

• Patients suffering from any of the following diseases: active tuberculosis, severe bronchiectasis, lung abscess, aspiration pneumonia, lung tumor, non-infectious interstitial lung disease, pulmonary edema, atelectasis, pneumothorax, pleural effusion , Pulmonary embolism, pulmonary eosinophilic infiltration, and pulmonary vasculitis;
• Patients with a history of tumors or patients with current tumors;
• Severe heart disease, such as coronary heart disease, heart failure, etc.;
• diabetes;

Laborértékek

• The patient has severe renal impairment: creatinine clearance rate <30ml/min/1.73m2 or serum creatinine>265μmol/L (>3mg/dL);
• Patients suffering from liver disease or severe liver damage: ALT, AST> 2 times the upper limit of normal;
• Severe coagulopathy: INR>1.4, PTT>40s, PLT<150x103 cells

Egyéb

• pregnancy;
• Severe COPD, FEV1 predicted value ≤50%;
• Bronchial Asthma;
• Severe alcoholism;
• Have used antibiotics within two months,
• Used systemic and local hormones;
• Cannot sign the informed consent form;

• Have the ability to communicate orally or in writing and sign an informed consent form;
• Age from 18 to 70 years (the age of patients with mild to moderate COPD <75 years), regardless of gender;
• Meet the above-mentioned early diagnosis criteria for high-risk patients with COPD/early-stage COPD/mild to moderate COPD.