Investigation of Chronic Obstructive Pulmonary Disease (COPD) Phenotypes and Endotypes in China

Korábbi kezelés

• Having undergone lung surgery.
• Participating or plan to participant in any clinical studies where investigational drugs were tested.
• Have evidence of alcohol or drug abuse.
• Have received a blood transfusion in the 4 weeks prior to study start.
• On long-term oral corticosteroids.

Más betegség

• Known respiratory disorders or significant inflammatory disease other than COPD.
• Serious, uncontrolled disease (including serious psychological disorders)
• Confirmed cancer, unless participants in remission for more than or equal to (>=)5 years.
• Known disorders other than COPD that may significantly impact clinical assessments
  • Additional exclusion criteria for chronic bronchitis participants and healthy participants:
• Known disorders that may significantly impact clinical assessments.

Egyéb

• Unable or unwilling to use required digital devices (sub- cohort only).
• Unable to walk.
• Unable to read and understand Mandarin Chinese.
  • Additional exclusion criteria for COPD participants:
• Current primary diagnosis of asthma (participants with a primary diagnosis of COPD but who also had asthma [Asthma COPD overlap {ACO}] could be included).
• FVC <80% Predicted.

• Male or female participants, aged 50-80 years inclusive. A female is eligible only if she is of non-child bearing potential.
• Body mass index (BMI) less than (<)35.
• A signed and dated written informed consent is obtained prior to participation.
  • Additional inclusion criteria for COPD participants:
• A Baseline (post-bronchodilator) (FEV1/FVC) ratio <70 percent (%).
• Clinically stable and has no exacerbations for at least 1 month prior to recruitment.
• Ever smoker or never smoker.
  • Additional inclusion criteria for chronic bronchitis participants:
• Free from other significant diseases.
• Baseline post-bronchodilator FEV1/FVC ratio more than (>)70%.
• Chronic bronchitis is defined as at least 3 months of cough and phlegm in a year in the past 2 years.
• Clinically stable and has no exacerbations for at least 1 month prior to recruitment.
• Ever smoker or never smoker
  • Additional inclusion criteria for healthy participants:
• Free from any significant diseases
• Baseline post-bronchodilator FEV1/FVC ratio >70%.
• A CAT score <10.
• Never smoker. Passive smoker is not eligible.