Breathing Training for Improving Cardiovascular Health in Older Adults With Sleep Apnea

Korábbi kezelés

• Alcohol or illegal drug dependence or abuse
• Uncontrolled thyroid disease or change in thyroid medication within previous 3 months

Más betegség

• Chronic overt and poorly controlled medical condition (e.g., diabetes, chronic kidney disease, cancer, congestive heart failure)

Életkor

• Age <50

Egyéb

• AHI <15
• Individuals with central or mixed sleep disordered breathing
• Severe hypoxemia (<80% for >10% of recording time) during sleep
• ESS >15
• SBP ≥160 or DBP ≥120
• Current smoker
• Cheyne-Stokes Respiration
• Regular/vigorous aerobic exercise (> 4 bouts/week, >30 min/bout at high workload >6 METS)

• Age 50 and older
• Ability to understand study procedures and to comply with them for the entire length of the study
• Ability to provide informed consent;
• Willing to accept random assignment to condition
• AHI ≥15
• Individuals with who are unwilling or unable to adhere to CPAP
• Individuals who are adherent to CPAP therapy (i.e., 4 hours/night on 70%/nights over 30 days in the first 3 months of initial usage)
• Individuals who are adherent to mandibular advancement device each night
• Above-normal SBP (i.e., SBP ≥120)
• BMI ≤40 kg/m2
• Weight stable in the prior 3 months (<3.0 kg weight change) and willing to remain weight stable throughout the study
• No change in anti-hypertensive medications or other medications (prescription or dosing) in the prior 3 months and willingness to maintain current medication regimen throughout the study
• Absence of unstable clinical disease as determined by medical history, physical examination, and blood chemistries
• Total cholesterol <240 mg/dL
• Fasting plasma glucose <300 mg/dL