Efficacy of Diet on Quality of Life in Multiple Sclerosis

Korábbi kezelés

• Use of insulin, Coumadin, weight loss medications such as orlistat that causes fat malabsorption.
• Worsening of symptoms resulting in the initiation or change of treatment including steroids (solumedrol, prednisone, etc.) or disease-modifying medications in 4 weeks prior to consent.
• Treatment for cancer by radiation or chemotherapy in 12 months prior to consent, other than skin cancer.

Más betegség

• Moderate or severe mental impairment.
• Diagnosis of clinically significant heart disease, liver disease, kidney disease, or history of oxalate kidney stones.
• Diagnosis of type II diabetes that does not have approval from treating physicians to adopt any of the 3 study diets.
• Clinical diagnosis of moderate to severe psychiatric disease that makes study adherence more difficult (e.g., schizophrenia, bi-polar disease, severe depression and/or anxiety).
• An active eating disorder such as anorexia, bulimia, binge eating, or orthorexia.
• History of diagnosed fat intolerance/malabsorption such as cholecystectomy or uncontrolled exocrine pancreatic insufficiency.

Egyéb

• Measurement of BMI <20.
• Confirmation of pregnancy or planning to become pregnant in the next 2 years.
• Participation in another research study investigating MS treatments, diet, or exercise.
• Presence of a contraindication to completing a brain MRI or having claustrophobia which interferes with completion of MRI studies without the use of sedation.

• A definitive diagnosis of RRMS based on the 2017 revised McDonald Criteria.
• The ability to prepare, or availability of someone to prepare, home-cooked meals.
• Must own a computer, smartphone, or tablet device that has internet access to complete online surveys and capable of running study related applications.
• Must be willing to follow study procedures outlined and explained to them.
• Be between the ages of 18 to 70 at the time of consent.
• Must be able to walk 25 feet without support.
• Willingness to be randomized and follow any of the study diets.
• Must consent to sharing the clinical notes from their primary care and neurology providers during the study period.

A regiszterben nem jelölt feltételek

• Eligibility for the run-in phase of the study:
• Participants will be eligible to enroll in the fourteen-day run-in phase of the study if they meet the following inclusion and exclusion criteria: