Biliary Drainage Plus HAIC in Locally Advanced pCCA

Korábbi kezelés

• Previous systematic chemotherapy or radiotherapy.

Más betegség

• Allergic to contrast agent.
• Allergic to 5-fluorouracil, or have metabolic disorder of 5-fluorouracil.
• Patients with complications such as bile leakage and bleeding after PTCD
• N2 lymphatic metastasis, extrahepatic metastasis, or coinstantaneous a lot of malignant hydrothorax or ascites.
• History of organ transplantation.
• Coinstantaneous infection and need anti-infection therapy.
• Coinstantaneous peripheral nervous system disorder or with history of obvious mental disorder and central nervous system disorder.
• Diagnosed other kinds of malignant within 5 years, except for non-melanoma skin cancer and carcinoma in situ of cervix.
• Uncorrectable coagulation disorder.
• Obvious abnormal in ECG or obvious clinical symptoms of heartdisease, like congestive heart failure (CHF), coronary heart disease with obvious clinical symptoms, unmanageable arrhythmia and hypertension.
• Severe liver disease (like cirrhosis), renal disease, respiratory disease,unmanageable diabetes or other kinds of systematic disease.

Egyéb

• Pregnant or lactational.
• Without legal capacity.

• Locally advanced perihilar cholangiocarcinoma proved by histology or cytology.
• Locally advanced unresectable perihilar cholangiocarcinoma, decided by hepatobiliary doctor and radiologist.
• Age from 18 years old to 80 years old.
• The performance of Eastern Cooperative Oncology Group (ECOG) <2
• Child-Pugh A or Child-Pugh B (≤ grade 7).
• Expectant survival time ≥ 3 months.
• Baseline blood count test and blood biochemical must meet following criteria:
  • Hemoglobin ≥ 90 g/L;
  • Absolute neutrophil count ≥ 1.5×10\^9/L;
  • Blood platelet count ≥ 100×10\^9/L;
  • Serum creatinine ≤ 1.5 times of ULN;
  • Albumin ≥ 30 g/L
• Patients sign informed consent.