A Trial to Learn How Well Finerenone Works and How Safe it is in Adult Participants With Non-diabetic Chronic Kidney Disease

Rövid összefoglaló (regiszter, angolul)

Researchers are looking for a better way to treat people who have non-diabetic chronic kidney disease (non-diabetic CKD). The trial treatment, finerenone, is being developed to help people who have long lasting kidney disease, also known as chronic kidney disease (CKD). It works by blocking a certain hormone called aldosterone that causes injury and inflammation in the heart and kidney which is known to play a role in CKD. In this trial, the researchers want to learn if finerenone helps to slow down the worsening of the participants' non-diabetic CKD compared to a placebo. A placebo looks like a trial treatment but does not have any medicine in it. The trial will include about 1,580 men and women who are at least 18 years old. The participants will take finerenone or a placebo once a day as tablets by mouth. All of the participants will also continue to take their current medicine for their CKD. The participants will be in the trial for up to about 50 months. During the trial, the doctors will collect blood and urine samples and check the participants' health. The participants will also answer questions about how they are feeling and what adverse events they are having. An adverse event is a medical problem that happens during the trial. Doctors keep track of all adverse events that happen in trials, even if they do not think the adverse events might be related to the trial treatments.

Mit vállalsz

• Vizsgálat típusa: Beavatkozással járó · 3. fázis
• Bevont résztvevők: 1584
• 2021. szept. 21. és az elsődleges befejezés (2025. dec. 31.) között
• 316 helyszín, 24 országban
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Kapcsolódó publikációk

• Finerenone in hypertensive non-diabetic chronic kidney disease: a FIND-CKD subgroup analysis.Eur Heart J · 2026 · PMID 42669052
• Finerenone in Patients With Chronic Kidney Disease Due to Glomerular Diseases: A Randomized Clinical Trial.JAMA · 2026 · PMID 42246414
• Finerenone in Persons with Chronic Kidney Disease without Diabetes.N Engl J Med · 2026 · PMID 42246672