NCT05058651Toboroz2/3. fázis
Evaluating the Addition of the Immunotherapy Drug Atezolizumab to Standard Chemotherapy Treatment for Advanced or Metastatic Neuroendocrine Carcinomas That Originate Outside the Lung
Randomized Phase II/III Trial of First Line Platinum/Etoposide With or Without Atezolizumab (NSC#783608) in Patients With Advanced or Metastatic Poorly Differentiated Extrapulmonary Neuroendocrine Carcinomas (NEC)
Forrás: ClinicalTrials.gov · Utoljára frissítve: 2026. nov. 6.
Rövid összefoglaló (regiszter, angolul)
This phase II/III trial compares the effect of immunotherapy with atezolizumab in combination with standard chemotherapy with a platinum drug (cisplatin or carboplatin) and etoposide versus standard therapy alone for the treatment of poorly differentiated extrapulmonary (originated outside the lung) neuroendocrine cancer that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced) or that has spread from where it first started (primary site) to other places in the body (metastatic). The other aim of this trial is to compare using atezolizumab just at the beginning of treatment versus continuing it beyond the initial treatment. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Cisplatin and carboplatin are in a class of medications known as platinum-containing compounds that work by killing, stopping or slowing the growth of cancer cells. Etoposide is in a class of medications known as podophyllotoxin derivatives. It blocks a certain enzyme needed for cell division and DNA repair, and it may kill cancer cells. Giving atezolizumab in combination with a platinum drug (cisplatin or carboplatin) and etoposide may work better in treating patients with poorly differentiated extrapulmonary neuroendocrine cancer compared to standard therapy with a platinum drug (cisplatin or carboplatin) and etoposide alone.
- Állapot (regiszter)
- Toboroz
- Fázis (regiszter)
- 2/3. fázis
- Vizsgálattípus
- Beavatkozással járó
- Résztvevők száma
- 189 (tervezett)
- Első benyújtás
- 2021. szept. 25.
- Kezdés
- 2022. jún. 28.
- Elsődleges befejezés
- 2028. okt. 1.
- Fő szponzor
- National Cancer Institute (NCI)
- Betegségek
- Neuroendokrin daganatok
- NCT-szám
- NCT05058651
Mit vállalsz
- Vizsgálat típusa: Beavatkozással járó · 2/3. fázis
- Tervezett résztvevők: 189
- 2022. jún. 28. és az elsődleges befejezés (2028. okt. 1.) között
- 266 helyszín, 1 országban
- Vizitek és vizsgálatok: kérdezd a vizsgálat csapatát, a regiszter nem sorolja fel őket
A(z) ClinicalTrials.gov regisztermezőiből összeállítva. A vizsgálat felépítését írja le.
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Kiket keres a vizsgálat
- Participants must have histologically-confirmed (local site pathological confirmation sufficient) extrapulmonary poorly differentiated, neuroendocrine carcinoma (NEC)
- Participants must have disease that is unresectable or metastatic and not eligible for definitive therapy as deemed per the treating investigator
- Participants must have radiologically evaluable disease, measurable or non-measurable, per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 criteria. All measurable and nonmeasurable lesions must be assessed by CT scan with IV contrast of the chest/abdomen/and pelvis (or CT chest without contrast and MRI abdomen/pelvis with gadolinium contrast, if contraindication to CT iodinated contrast) within 28 days prior to registration. While may be used for routine clinical evaluation, PET scans and bone scans alone are not acceptable for disease assessment while participating in this study. All known sites of disease must be assessed and documented on the Baseline Tumor Assessment Form
- Participants must have brain MRI (or CT head with contrast if there is contraindication to MRI brain) if clinically indicated within 28 days prior to registration. Note: Brain imaging is not required in participants without known and/or clinical concern for brain metastases. Participants with asymptomatic central nervous system (CNS) metastases are eligible if one or more of the following apply:
- Participants who have received treatment for brain metastases must have:
- No evidence of radiological progression (by MRI brain or CT head with contrast if there is contraindication to MRI brain) within 28 days prior to registration
- Discontinued all corticosteroids at least 14 days prior to registration
- Participants with treatment-naive brain lesions must have:
- No lesion measuring > 2.0 cm in size in any axis
- MRI brain or CT head with contrast (if there is contraindication to MRI brain) demonstrating no evidence for mass effect, edema, or other impending neurological compromise within 28 days prior to registration
- No evidence of radiological progression (by MRI brain or CT head with contrast if there is contraindication to MRI brain) within 28 days prior to registration
- No need for > 2 mg of dexamethasone (or equivalent of > 10 mg prednisone) per day at time of registration
- Participants must not have symptomatic central nervous system (CNS) metastases
- Participants must not have known or suspected leptomeningeal disease
- Participants with prior history of non-metastatic (localized/locally advanced disease) extrapulmonary poorly differentiated NEC may have had prior platinum-based therapy +/- radiation +/- surgery provided that all therapy was completed >= 6 months prior to registration
- Participants must discontinue denosumab prior to study registration and plan to replace with a bisphosphonate while on the study
- Participants must not have had prior treatment for advanced or metastatic NEC EXCEPT one cycle of platinum (carboplatin/cisplatin) + etoposide is allowed prior to registration. Other chemotherapy regimens are not allowed. For participants with prostate or urothelial NEC, prior chemotherapy for the non-NEC component (e.g. adenocarcinoma or urothelial) is allowed as long as such therapy was completed >= 24 weeks prior to registration and participants have recovered from all prior toxicities to =< grade 1.
- Participants must not have had prior treatment with an anti-PD-1, anti-PD-L1, antiPD-L2, CD137 agonists, anti-CTLA-4 agent, or any other immune checkpoint inhibitors for any neuroendocrine neoplasm. Immune checkpoint inhibitors given for other cancer indications are allowed provided last therapy was given at least 12 months prior to study registration
- Participants must not have received treatment with systemic immunostimulatory agents including, but not limited to, interferon and interleukin2 [IL-2] within 4 weeks or 5 half-lives of the drug (whichever is longer) prior to registration
- Participants must not have had history of known severe allergy, anaphylactic, or other hypersensitivity reactions to chimeric or humanized antibodies, including to Chinese hamster ovary cell products or to any component of the atezolizumab formulation, cisplatin, carboplatin, or etoposide
- Participants must not be on active systemic therapy for another cancer with the exception of hormonal therapy including androgen deprivation therapy (e.g., gonadotropin-releasing hormone [GnRH] agonists or antagonists), which can be continued while participants are receiving protocol therapy. Use of enzalutamide or apalutamide is permitted after completion of chemotherapy and must be held during chemotherapy for participants receiving prior to enrollment. Use of darolutamide is permitted during chemotherapy. Glucocorticoid-containing regimens, including abiraterone, are not permitted.
- Participants must be >= 18 years of age
- Participants must have a Zubrod performance status of =< 2 within 28 days prior to registration
- Participants must have a complete medical history and physical exam within 28 days prior to registration
- Absolute neutrophil count (ANC) >= 1.5 x 10\^9 /L (obtained within 14 days prior to registration. For participants who received a cycle of chemotherapy prior to registration, at least 21 days must have elapsed between day 1 of platinum + etoposide and performance of these tests)
- Hemoglobin >= 9.0 g/dl (obtained within 14 days prior to registration. For participants who received a cycle of chemotherapy prior to registration, at least 21 days must have elapsed between day 1 of platinum + etoposide and performance of these tests)
- Platelet count >= 100 x 10\^9/L (obtained within 14 days prior to registration. For participants who received a cycle of chemotherapy prior to registration, at least 21 days must have elapsed between day 1 of platinum + etoposide and performance of these tests)
- Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 x institutional upper limit of normal (ULN) (obtained within 14 days prior to registration. For participants who received a cycle of chemotherapy prior to registration, at least 21 days must have elapsed between day 1 of platinum + etoposide and performance of these tests)
- Serum total bilirubin =< 1.5 x ULN (obtained within 14 days prior to registration. For participants who received a cycle of chemotherapy prior to registration, at least 21 days must have elapsed between day 1 of platinum + etoposide and performance of these tests)
- Adequate renal function as defined by any 1 of the following: 1) Measured creatinine clearance (CL) > 50 mL/min OR 2) Calculated creatinine CL > 50 mL/min by the Cockcroft-Gault formula OR by 24-hour urine collection for determination of creatinine clearance (obtained within 14 days prior to registration. For participants who received a cycle of chemotherapy prior to registration, at least 21 days must have elapsed between day 1 of platinum + etoposide and performance of these tests)
- Participants must not have uncontrolled or symptomatic hypercalcemia (> 1.5 mmol/L ionized calcium or calcium > 12 mg/dL or corrected serum calcium > ULN) within 14 days prior to registration. Participants who have asymptomatic hypercalcemia are eligible provided that medical therapy to treat the hypercalcemia is planned
- Participants must not have a diagnosis of immunodeficiency nor be receiving systemic steroid therapy (equivalent of > 20 mg of hydrocortisone per day) or any other form of immunosuppressive therapy within 14 days prior to registration
- Participants must not have active or history of autoimmune disease or immune deficiency, including, but not limited to myasthenia gravis, myositis, autoimmune hepatitis, systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, antiphospholipid antibody syndrome, Wegener granulomatosis, Sjogren syndrome, Guillain-Barre syndrome, or multiple sclerosis with the following exceptions:
- Patients with a history of autoimmune-related hypothyroidism who are on thyroid-replacement hormone are eligible for the study
- Patients with controlled type 1 diabetes mellitus who are on an insulin regimen are eligible for the study
- Patients with eczema, psoriasis, lichen simplex chronicus, or vitiligo with dermatologic manifestations only (e.g., patients with psoriatic arthritis are excluded) are eligible for the study provided all of following conditions are met:
- Rash must cover < 10% of body surface area
- Disease is well controlled at baseline and requires only low-potency topical corticosteroids
- No occurrence of acute exacerbations of the underlying condition requiring psoralen plus ultraviolet A radiation, methotrexate, retinoids, biologic agents, oral calcineurin inhibitors, or high-potency or oral corticosteroids within the previous 12 months
- Participants must not have history of idiopathic pulmonary fibrosis, organizing pneumonia (e.g., bronchiolitis obliterans), drug-induced pneumonitis, idiopathic pneumonitis, or evidence of active pneumonitis on screening chest CT scan. NOTE: History of radiation pneumonitis in the radiation field (fibrosis) is permitted
- Participants must not have significant cardiovascular disease, such as New York Heart Association class II or greater cardiac disease, myocardial infarction within 3 months prior to registration, unstable arrythmias, or unstable angina
- Participants must not have had a major surgical procedure other than for diagnosis within 28 days prior to registration. Participant must not plan to receive a major surgical procedure during the course of protocol treatment. NOTE: Patient port placement is not considered a major surgery
- Participants must not have severe infections (i.e., Common Terminology Criteria for Adverse Events [CTCAE] grade >= 2) at time of registration, including but not limited to hospitalization for complications for infection, bacteremia, or severe pneumonia
- Participants must not have known active tuberculosis
- Participants with evidence of chronic hepatitis B virus (HBV) infection must have undetectable HBV viral load, with testing performed as clinically indicated
- Participants with a history of hepatitis C virus (HCV) infection must have been treated and cured. Participants with active HCV infection who are currently on treatment must have an undetectable HCV viral load, with testing performed as clinically indicated
- Participants with known human immunodeficiency virus (HIV)-infection must be on effective anti-retroviral therapy at time of registration and have undetectable HIV viral load within 6 months of registration
- Participants must not have prior allogeneic bone marrow transplantation or solid organ transplant
- Participants must not have received administration of a live, attenuated vaccine (e.g., FluMist [registered trademark]) within 28 days prior to initiation of study treatment, during treatment with atezolizumab, and not plan to receive for 5 months after the last dose of atezolizumab
- Participants must not be pregnant due to the possibility of harm to the fetus. Individuals who are of reproductive potential must have agreed to use an effective contraceptive method (with details provided as a part of the consent process) during the treatment period and for 5 months after the final dose of atezolizumab. A person who has had menses at any time in the preceding 12 consecutive months or who has semen likely to contain sperm is considered to be of "reproductive potential." In addition to routine contraceptive methods, "effective contraception" also includes refraining from sexual activity that might result in pregnancy and surgery intended to prevent pregnancy (or with a side effect of pregnancy prevention) including hysterectomy, bilateral oophorectomy, bilateral tubal ligation/occlusion, and vasectomy with testing showing no sperm in the semen
- Participants must be offered the opportunity to participate in specimen banking. With participant consent, specimens must be collected and submitted via the Southwest Oncology Group (SWOG) Specimen Tracking System
- Participants must be informed of the investigational nature of this study and must sign and give informed consent in accordance with institutional and federal guidelines
Életkor a regiszterben: 18 év – - · Nem: nők és férfiak · Egészséges önkénteseket nem fogad
Helyszínek (266)
Helyszínek a regiszter sorrendjében. Ha a profilodba mented a városodat, távolság szerint rendeződnek.
| Helyszín | Város | Ország | Helyszín állapota |
|---|---|---|---|
| Hawaii Cancer Care - Westridge | ‘Aiea | Egyesült Államok | Toboroz |
| Pali Momi Medical Center | ‘Aiea | Egyesült Államok | Felfüggesztve |
| Mary Greeley Medical Center | Ames | Egyesült Államok | Toboroz |
| McFarland Clinic - Ames | Ames | Egyesült Államok | Toboroz |
| Community Hospital of Anaconda | Anaconda | Egyesült Államok | Toboroz |
| Kaiser Permanente-Anaheim | Anaheim | Egyesült Államok | Toboroz |
| Alaska Women's Cancer Care | Anchorage | Egyesült Államok | Felfüggesztve |
| UI Health Care Mission Cancer and Blood - Ankeny Clinic | Ankeny | Egyesült Államok | Toboroz |
| Trinity Health Saint Joseph Mercy Hospital Ann Arbor | Ann Arbor | Egyesült Államok | Toboroz |
| University of Michigan Rogel Cancer Center | Ann Arbor | Egyesült Államok | Toboroz |
| Sutter Auburn Faith Hospital | Auburn | Egyesült Államok | Toboroz |
| Sutter Cancer Centers Radiation Oncology Services-Auburn | Auburn | Egyesült Államok | Toboroz |
| Rush-Copley Medical Center | Aurora | Egyesült Államok | Felfüggesztve |
| Kaiser Permanente-Baldwin Park | Baldwin Park | Egyesült Államok | Toboroz |
| LSU Health Baton Rouge-North Clinic | Baton Rouge | Egyesült Államok | Toboroz |
| Our Lady of the Lake Physician Group | Baton Rouge | Egyesült Államok | Toboroz |
| Bronson Battle Creek | Battle Creek | Egyesült Államok | Toboroz |
| Kaiser Permanente-Bellflower | Bellflower | Egyesült Államok | Toboroz |
| Saint Charles Health System | Bend | Egyesült Államok | Toboroz |
| Alta Bates Summit Medical Center-Herrick Campus | Berkeley | Egyesült Államok | Toboroz |
| Saint Vincent Frontier Cancer Center | Billings | Egyesült Államok | Toboroz |
| Billings Clinic Cancer Center | Billings | Egyesült Államok | Toboroz |
| McFarland Clinic - Boone | Boone | Egyesült Államok | Felfüggesztve |
| United Hospital Center | Bridgeport | Egyesült Államok | Toboroz |
| Trinity Health IHA Medical Group Hematology Oncology - Brighton | Brighton | Egyesült Államok | Toboroz |
| Trinity Health Medical Center - Brighton | Brighton | Egyesült Államok | Toboroz |
| Henry Ford Cancer Institute-Downriver | Brownstown | Egyesült Államok | Toboroz |
| Roswell Park Cancer Institute | Buffalo | Egyesült Államok | Fut, nem toboroz |
| Lahey Clinic | Burlington | Egyesült Államok | Toboroz |
| Minnesota Oncology - Burnsville | Burnsville | Egyesült Államok | Toboroz |
| Sutter Cancer Centers Radiation Oncology Services-Cameron Park | Cameron Park | Egyesült Államok | Toboroz |
| Trinity Health Medical Center - Canton | Canton | Egyesült Államok | Toboroz |
| Trinity Health IHA Medical Group Hematology Oncology - Canton | Canton | Egyesült Államok | Toboroz |
| Saint Francis Medical Center | Cape Girardeau | Egyesült Államok | Toboroz |
| Mercy San Juan Medical Center | Carmichael | Egyesült Államok | Toboroz |
| Mercy Cancer Center - Carmichael | Carmichael | Egyesült Államok | Toboroz |
| Saint Anthony Regional Hospital | Carroll | Egyesült Államok | Toboroz |
| Duke Cancer Center Cary | Cary | Egyesült Államok | Felfüggesztve |
| Centralia Oncology Clinic | Centralia | Egyesült Államok | Toboroz |
| WellSpan Medical Oncology and Hematology | Chambersburg | Egyesült Államok | Toboroz |
| Medical University of South Carolina | Charleston | Egyesült Államok | Felfüggesztve |
| Atrium Health Pineville/LCI-Pineville | Charlotte | Egyesült Államok | Toboroz |
| Carolinas Medical Center/Levine Cancer Institute | Charlotte | Egyesült Államok | Toboroz |
| Levine Cancer Institute-Ballantyne | Charlotte | Egyesült Államok | Toboroz |
| Atrium Health University City/LCI-University | Charlotte | Egyesült Államok | Toboroz |
| Levine Cancer Institute-SouthPark | Charlotte | Egyesült Államok | Toboroz |
| Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital | Chelsea | Egyesült Államok | Toboroz |
| Chelsea Hospital | Chelsea | Egyesült Államok | Toboroz |
| Northwestern University | Chicago | Egyesült Államok | Toboroz |
| University of Chicago Comprehensive Cancer Center | Chicago | Egyesült Államok | Toboroz |
| Providence Cancer Institute Clackamas Clinic | Clackamas | Egyesült Államok | Felfüggesztve |
| Southeastern Medical Oncology Center-Clinton | Clinton | Egyesült Államok | Toboroz |
| Henry Ford Macomb Hospital-Clinton Township | Clinton Township | Egyesült Államok | Toboroz |
| UI Health Care Mission Cancer and Blood - West Des Moines Clinic | Clive | Egyesült Államok | Toboroz |
| Mercy Cancer Center-West Lakes | Clive | Egyesült Államok | Toboroz |
| Kootenai Health - Coeur d'Alene | Coeur d'Alene | Egyesült Államok | Toboroz |
| Ohio State University Comprehensive Cancer Center | Columbus | Egyesült Államok | Toboroz |
| Atrium Health Cabarrus/LCI-Concord | Concord | Egyesült Államok | Toboroz |
| Greater Regional Medical Center | Creston | Egyesült Államok | Fut, nem toboroz |
| UChicago Medicine Northwest Indiana | Crown Point | Egyesült Államok | Toboroz |
| Parkland Memorial Hospital | Dallas | Egyesült Államok | Toboroz |
| UT Southwestern Simmons Cancer Center - RedBird | Dallas | Egyesült Államok | Toboroz |
| UT Southwestern/Simmons Cancer Center-Dallas | Dallas | Egyesült Államok | Toboroz |
| Carle at The Riverfront | Danville | Egyesült Államok | Toboroz |
| Henry Ford Medical Center-Fairlane | Dearborn | Egyesült Államok | Toboroz |
| Corewell Health Dearborn Hospital | Dearborn | Egyesült Államok | Toboroz |
| Cancer Care Specialists of Illinois - Decatur | Decatur | Egyesült Államok | Toboroz |
| Decatur Memorial Hospital | Decatur | Egyesült Államok | Toboroz |
| Northwestern Medicine Cancer Center Kishwaukee | DeKalb | Egyesült Államok | Toboroz |
| AdventHealth Porter | Denver | Egyesült Államok | Toboroz |
| Smilow Cancer Hospital-Derby Care Center | Derby | Egyesült Államok | Toboroz |
| UI Health Care Mission Cancer and Blood - Des Moines Clinic | Des Moines | Egyesült Államok | Toboroz |
| Broadlawns Medical Center | Des Moines | Egyesült Államok | Toboroz |
| Mercy Medical Center - Des Moines | Des Moines | Egyesült Államok | Toboroz |
| UI Health Care Mission Cancer and Blood - Laurel Clinic | Des Moines | Egyesült Államok | Toboroz |
| Iowa Methodist Medical Center | Des Moines | Egyesült Államok | Toboroz |
| Wayne State University/Karmanos Cancer Institute | Detroit | Egyesült Államok | Fut, nem toboroz |
| Henry Ford Hospital | Detroit | Egyesült Államok | Toboroz |
| Henry Ford Health Saint John Hospital | Detroit | Egyesült Államok | Toboroz |
| Saint Luke's Hospital of Duluth | Duluth | Egyesült Államok | Fut, nem toboroz |
| Duke University Medical Center | Durham | Egyesült Államok | Toboroz |
| Henry Ford River District Hospital | East China Township | Egyesült Államok | Toboroz |
| Marshfield Medical Center-EC Cancer Center | Eau Claire | Egyesült Államok | Toboroz |
| Fairview Southdale Hospital | Edina | Egyesült Államok | Toboroz |
| Minnesota Oncology - Edina | Edina | Egyesült Államok | Toboroz |
| Crossroads Cancer Center | Effingham | Egyesült Államok | Toboroz |
| Carle Physician Group-Effingham | Effingham | Egyesült Államok | Toboroz |
| Mercy Cancer Center - Elk Grove | Elk Grove | Egyesült Államok | Toboroz |
| Ephrata Cancer Center | Ephrata | Egyesült Államok | Toboroz |
| The Queen's Medical Center - West Oahu | ‘Ewa Beach | Egyesült Államok | Toboroz |
| Smilow Cancer Hospital Care Center-Fairfield | Fairfield | Egyesült Államok | Toboroz |
| Corewell Health Farmington Hills Hospital | Farmington Hills | Egyesült Államok | Toboroz |
| Weisberg Cancer Treatment Center | Farmington Hills | Egyesült Államok | Fut, nem toboroz |
| Cancer Hematology Centers - Flint | Flint | Egyesült Államok | Toboroz |
| Genesys Hurley Cancer Institute | Flint | Egyesült Államok | Toboroz |
| Hurley Medical Center | Flint | Egyesült Államok | Toboroz |
| Genesee Hematology Oncology PC | Flint | Egyesült Államok | Felfüggesztve |
| Kaiser Permanente-Fontana | Fontana | Egyesült Államok | Toboroz |
| McFarland Clinic - Trinity Cancer Center | Fort Dodge | Egyesült Államok | Toboroz |
| Holy Cross Hospital | Fort Lauderdale | Egyesült Államok | Toboroz |
| UT Southwestern/Simmons Cancer Center-Fort Worth | Fort Worth | Egyesült Államok | Toboroz |
| Palo Alto Medical Foundation-Fremont | Fremont | Egyesült Államok | Toboroz |
| Levine Cancer Institute-Gaston | Gastonia | Egyesült Államok | Toboroz |
| Northwestern Medicine Cancer Center Delnor | Geneva | Egyesült Államok | Toboroz |
| Adams Cancer Center | Gettysburg | Egyesült Államok | Toboroz |
| Smilow Cancer Hospital Care Center at Glastonbury | Glastonbury | Egyesült Államok | Felfüggesztve |
| Northwestern Medicine Glenview Outpatient Center | Glenview | Egyesült Államok | Toboroz |
| Southeastern Medical Oncology Center-Goldsboro | Goldsboro | Egyesült Államok | Toboroz |
| Trinity Health Grand Rapids Hospital | Grand Rapids | Egyesült Államok | Toboroz |
| Corewell Health Grand Rapids Hospitals - Butterworth Hospital | Grand Rapids | Egyesült Államok | Toboroz |
| Northwestern Medicine Grayslake Outpatient Center | Grayslake | Egyesült Államok | Toboroz |
| Benefis Sletten Cancer Institute | Great Falls | Egyesült Államok | Toboroz |
| Smilow Cancer Hospital Care Center at Greenwich | Greenwich | Egyesült Államok | Toboroz |
| Henry Ford Saint John Hospital - Van Elslander | Grosse Pointe Woods | Egyesült Államok | Toboroz |
| Henry Ford Saint John Hospital - Academic | Grosse Pointe Woods | Egyesült Államok | Toboroz |
| Henry Ford Saint John Hospital - Breast | Grosse Pointe Woods | Egyesült Államok | Toboroz |
| Smilow Cancer Hospital Care Center - Guilford | Guilford | Egyesült Államok | Toboroz |
| WellSpan Medical Oncology and Hematology | Hanover | Egyesült Államok | Toboroz |
| Kaiser Permanente South Bay | Harbor City | Egyesült Államok | Toboroz |
| Smilow Cancer Hospital Care Center at Saint Francis | Hartford | Egyesült Államok | Felfüggesztve |
| Ingalls Memorial Hospital | Harvey | Egyesült Államok | Toboroz |
| University of Hawaii Cancer Center | Honolulu | Egyesült Államok | Toboroz |
| Queen's Cancer Center - Kuakini | Honolulu | Egyesült Államok | Toboroz |
| Queen's Medical Center | Honolulu | Egyesült Államok | Toboroz |
| Straub Clinic and Hospital | Honolulu | Egyesült Államok | Toboroz |
| Queen's Cancer Cenrer - POB I | Honolulu | Egyesült Államok | Toboroz |
| Hawaii Cancer Care Inc - Waterfront Plaza | Honolulu | Egyesült Államok | Toboroz |
| Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center | Houston | Egyesült Államok | Toboroz |
| Ben Taub General Hospital | Houston | Egyesült Államok | Toboroz |
| Kaiser Permanente-Irvine | Irvine | Egyesült Államok | Toboroz |
| Allegiance Health | Jackson | Egyesült Államok | Toboroz |
| Mayo Clinic in Florida | Jacksonville | Egyesült Államok | Toboroz |
| Southeastern Medical Oncology Center-Jacksonville | Jacksonville | Egyesült Államok | Toboroz |
| McFarland Clinic - Jefferson | Jefferson | Egyesült Államok | Felfüggesztve |
| Mercy Hospital Joplin | Joplin | Egyesült Államok | Toboroz |
| West Michigan Cancer Center | Kalamazoo | Egyesült Államok | Toboroz |
| Bronson Methodist Hospital | Kalamazoo | Egyesült Államok | Toboroz |
| Logan Health Medical Center | Kalispell | Egyesült Államok | Toboroz |
| Gundersen Lutheran Medical Center | La Crosse | Egyesült Államok | Toboroz |
| Northwestern Medicine Lake Forest Hospital | Lake Forest | Egyesült Államok | Toboroz |
| Karmanos Cancer Institute at McLaren Greater Lansing | Lansing | Egyesült Államok | Fut, nem toboroz |
| Cancer Centers of Southwest Oklahoma Research | Lawton | Egyesült Államok | Toboroz |
| Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center | Lebanon | Egyesült Államok | Toboroz |
| Sechler Family Cancer Center | Lebanon | Egyesült Államok | Toboroz |
| AdventHealth Littleton | Littleton | Egyesült Államok | Toboroz |
| Trinity Health Saint Mary Mercy Livonia Hospital | Livonia | Egyesült Államok | Toboroz |
| Kaiser Permanente West Los Angeles | Los Angeles | Egyesült Államok | Toboroz |
| Kaiser Permanente Los Angeles Medical Center | Los Angeles | Egyesült Államok | Toboroz |
| Henry Ford Warren Hospital - Breast Macomb | Macomb | Egyesült Államok | Toboroz |
| Henry Ford Saint John Hospital - Macomb Medical | Macomb | Egyesült Államok | Toboroz |
| McFarland Clinic - Marshalltown | Marshalltown | Egyesült Államok | Toboroz |
| Marshfield Medical Center-Marshfield | Marshfield | Egyesült Államok | Toboroz |
| Carle Physician Group-Mattoon/Charleston | Mattoon | Egyesült Államok | Toboroz |
| East Jefferson General Hospital | Metairie | Egyesült Államok | Toboroz |
| LSU Healthcare Network / Metairie Multi-Specialty Clinic | Metairie | Egyesült Államok | Toboroz |
| Medical College of Wisconsin | Milwaukee | Egyesült Államok | Toboroz |
| Hennepin County Medical Center | Minneapolis | Egyesült Államok | Toboroz |
| Abbott-Northwestern Hospital | Minneapolis | Egyesült Államok | Toboroz |
| Marshfield Medical Center - Minocqua | Minocqua | Egyesült Államok | Toboroz |
| Community Medical Center | Missoula | Egyesült Államok | Toboroz |
| Memorial Medical Center | Modesto | Egyesült Államok | Toboroz |
| West Virginia University Healthcare | Morgantown | Egyesült Államok | Toboroz |
| Palo Alto Medical Foundation-Camino Division | Mountain View | Egyesült Államok | Toboroz |
| SSM Health Good Samaritan | Mount Vernon | Egyesült Államok | Toboroz |
| Trinity Health Muskegon Hospital | Muskegon | Egyesült Államok | Toboroz |
| Saint Alphonsus Cancer Care Center-Nampa | Nampa | Egyesült Államok | Toboroz |
| Vanderbilt University/Ingram Cancer Center | Nashville | Egyesült Államok | Toboroz |
| Providence Newberg Medical Center | Newberg | Egyesült Államok | Toboroz |
| Yale University | New Haven | Egyesült Államok | Toboroz |
| UC Comprehensive Cancer Center at Silver Cross | New Lenox | Egyesült Államok | Toboroz |
| University Medical Center New Orleans | New Orleans | Egyesült Államok | Toboroz |
| Mount Sinai Hospital | New York | Egyesült Államok | Fut, nem toboroz |
| Corewell Health Lakeland Hospitals - Niles Hospital | Niles | Egyesült Államok | Toboroz |
| Carle Cancer Institute Normal | Normal | Egyesült Államok | Toboroz |
| Carle BroMenn Medical Center | Normal | Egyesült Államok | Toboroz |
| Yale-New Haven Hospital North Haven Medical Center | North Haven | Egyesült Államok | Toboroz |
| Cancer and Hematology Centers of Western Michigan - Norton Shores | Norton Shores | Egyesült Államok | Felfüggesztve |
| Henry Ford Medical Center-Columbus | Novi | Egyesült Államok | Toboroz |
| Cancer Care Center of O'Fallon | O'Fallon | Egyesült Államok | Toboroz |
| Mercy Hospital Oklahoma City | Oklahoma City | Egyesült Államok | Toboroz |
| University of Oklahoma Health Sciences Center | Oklahoma City | Egyesült Államok | Toboroz |
| Kaiser Permanente-Ontario | Ontario | Egyesült Államok | Toboroz |
| Providence Willamette Falls Medical Center | Oregon City | Egyesült Államok | Toboroz |
| University of Chicago Medicine-Orland Park | Orland Park | Egyesült Államok | Toboroz |
| Northwestern Medicine Orland Park | Orland Park | Egyesült Államok | Toboroz |
| Palo Alto Medical Foundation Health Care | Palo Alto | Egyesült Államok | Toboroz |
| Kaiser Permanente - Panorama City | Panorama City | Egyesült Államok | Toboroz |
| AdventHealth Parker | Parker | Egyesült Államok | Toboroz |
| Lahey Clinic Peabody | Peabody | Egyesült Államok | Toboroz |
| Cancer Center at Saint Joseph's | Phoenix | Egyesült Államok | Toboroz |
| Mayo Clinic Hospital in Arizona | Phoenix | Egyesült Államok | Toboroz |
| FirstHealth of the Carolinas-Moore Regional Hospital | Pinehurst | Egyesült Államok | Toboroz |
| Trinity Health Saint Joseph Mercy Oakland Hospital | Pontiac | Egyesült Államok | Toboroz |
| Providence Saint Vincent Medical Center | Portland | Egyesült Államok | Toboroz |
| Providence Portland Medical Center | Portland | Egyesült Államok | Toboroz |
| Kootenai Clinic Cancer Services - Post Falls | Post Falls | Egyesült Államok | Toboroz |
| Duke Cancer Center Raleigh | Raleigh | Egyesült Államok | Toboroz |
| Rapid City Regional Hospital | Rapid City | Egyesült Államok | Toboroz |
| Corewell Health Reed City Hospital | Reed City | Egyesült Államok | Toboroz |
| Marshfield Medical Center-Rice Lake | Rice Lake | Egyesült Államok | Toboroz |
| UT Southwestern Clinical Center at Richardson/Plano | Richardson | Egyesült Államok | Toboroz |
| Kaiser Permanente-Riverside | Riverside | Egyesült Államok | Toboroz |
| Mayo Clinic in Rochester | Rochester | Egyesült Államok | Toboroz |
| UW Health Carbone Cancer Center Rockford | Rockford | Egyesült Államok | Toboroz |
| Levine Cancer Institute-Rock Hill | Rock Hill | Egyesült Államok | Toboroz |
| Mercy Cancer Center - Rocklin | Rocklin | Egyesült Államok | Toboroz |
| Sutter Roseville Medical Center | Roseville | Egyesült Államok | Toboroz |
| Sutter Cancer Centers Radiation Oncology Services-Roseville | Roseville | Egyesült Államok | Toboroz |
| Corewell Health William Beaumont University Hospital | Royal Oak | Egyesült Államok | Toboroz |
| Mercy Cancer Center - Sacramento | Sacramento | Egyesült Államok | Toboroz |
| Sutter Medical Center Sacramento | Sacramento | Egyesült Államok | Toboroz |
| Dartmouth Cancer Center - North | Saint Johnsbury | Egyesült Államok | Toboroz |
| Corewell Health Lakeland Hospitals - Saint Joseph Hospital | Saint Joseph | Egyesült Államok | Toboroz |
| Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center | Saint Joseph | Egyesült Államok | Toboroz |
| Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Egyesült Államok | Toboroz |
| United Hospital | Saint Paul | Egyesült Államok | Toboroz |
| Regions Hospital | Saint Paul | Egyesült Államok | Toboroz |
| Huntsman Cancer Institute/University of Utah | Salt Lake City | Egyesült Államok | Toboroz |
| Kaiser Permanente-San Diego Zion | San Diego | Egyesült Államok | Toboroz |
| Kootenai Clinic Cancer Services - Sandpoint | Sandpoint | Egyesült Államok | Toboroz |
| California Pacific Medical Center-Pacific Campus | San Francisco | Egyesült Államok | Toboroz |
| Kaiser Permanente-San Marcos | San Marcos | Egyesült Államok | Toboroz |
| Palo Alto Medical Foundation-Santa Cruz | Santa Cruz | Egyesült Államok | Toboroz |
| Sutter Pacific Medical Foundation | Santa Rosa | Egyesült Államok | Toboroz |
| Fred Hutchinson Cancer Center | Seattle | Egyesült Államok | Toboroz |
| University of Washington Medical Center - Montlake | Seattle | Egyesült Államok | Toboroz |
| Saint Francis Regional Medical Center | Shakopee | Egyesült Államok | Toboroz |
| Atrium Health Cleveland/LCI-Cleveland | Shelby | Egyesült Államok | Toboroz |
| CoxHealth South Hospital | Springfield | Egyesült Államok | Toboroz |
| Springfield Clinic | Springfield | Egyesült Államok | Toboroz |
| Southern Illinois University School of Medicine | Springfield | Egyesült Államok | Toboroz |
| Springfield Memorial Hospital | Springfield | Egyesült Államok | Toboroz |
| Mercy Hospital Springfield | Springfield | Egyesült Államok | Toboroz |
| Smilow Cancer Hospital Care Center at Long Ridge | Stamford | Egyesült Államok | Toboroz |
| Marshfield Medical Center-River Region at Stevens Point | Stevens Point | Egyesült Államok | Toboroz |
| Mercy Hospital South | St Louis | Egyesült Államok | Toboroz |
| Stony Brook University Medical Center | Stony Brook | Egyesült Államok | Fut, nem toboroz |
| Palo Alto Medical Foundation-Sunnyvale | Sunnyvale | Egyesült Államok | Toboroz |
| Moffitt Cancer Center | Tampa | Egyesült Államok | Toboroz |
| Toledo Clinic Cancer Centers-Toledo | Toledo | Egyesült Államok | Felfüggesztve |
| Smilow Cancer Hospital-Torrington Care Center | Torrington | Egyesült Államok | Toboroz |
| Munson Medical Center | Traverse City | Egyesült Államok | Toboroz |
| Corewell Health Beaumont Troy Hospital | Troy | Egyesült Államok | Toboroz |
| Smilow Cancer Hospital Care Center-Trumbull | Trumbull | Egyesült Államok | Toboroz |
| Carle Cancer Center | Urbana | Egyesült Államok | Toboroz |
| Sutter Solano Medical Center/Cancer Center | Vallejo | Egyesült Államok | Toboroz |
| Henry Ford Health Warren Hospital | Warren | Egyesült Államok | Toboroz |
| Henry Ford Madison Heights Hospital - Breast | Warren | Egyesült Államok | Toboroz |
| Henry Ford Warren Hospital - GLCMS | Warren | Egyesült Államok | Toboroz |
| Northwestern Medicine Cancer Center Warrenville | Warrenville | Egyesült Államok | Toboroz |
| Smilow Cancer Hospital-Waterbury Care Center | Waterbury | Egyesült Államok | Toboroz |
| Smilow Cancer Hospital Care Center - Waterford | Waterford | Egyesült Államok | Toboroz |
| UI Health Care Mission Cancer and Blood - Waukee Clinic | Waukee | Egyesült Államok | Toboroz |
| Henry Ford West Bloomfield Hospital | West Bloomfield | Egyesült Államok | Toboroz |
| Mercy Medical Center-West Lakes | West Des Moines | Egyesült Államok | Toboroz |
| Smilow Cancer Hospital Care Center - Westerly | Westerly | Egyesült Államok | Toboroz |
| Marshfield Medical Center - Weston | Weston | Egyesült Államok | Toboroz |
| Woodland Memorial Hospital | Woodland | Egyesült Államok | Toboroz |
| Kaiser Permanente-Woodland Hills | Woodland Hills | Egyesült Államok | Toboroz |
| Henry Ford Wyandotte Hospital | Wyandotte | Egyesült Államok | Toboroz |
| University of Michigan Health - West | Wyoming | Egyesült Államok | Toboroz |
| WellSpan Health-York Cancer Center | York | Egyesült Államok | Toboroz |
| Cancer Care Associates of York | York | Egyesült Államok | Felfüggesztve |
| Rush-Copley Healthcare Center | Yorkville | Egyesült Államok | Felfüggesztve |
| Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus | Ypsilanti | Egyesült Államok | Toboroz |
| Huron Gastroenterology PC | Ypsilanti | Egyesült Államok | Toboroz |
Kapcsolódó publikációk
- Outcomes of Chemoimmunotherapy in Metastatic Pancreatic Neuroendocrine Carcinoma: A Single-Center Clinicopathologic Study.Oncologist · 2026 · PMID 42949119
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