Prolonged Cardiac ECG Patch Versus Conventional Holter For Detecting Atrial Fibrillation After Cerebral Ischemic Event

Korábbi kezelés

• Previous documented history of primary intracerebral bleeding.
• Previous documented history of AF or atrial flutter (a remote history of transient AF during perioperative period is not exclusionary).
• Intravenous drug users (IVDUs).
• Concomitant participation in other clinical trials involving investigational medications.

Más betegség

• Stroke of unknown time of symptom onset.
• Skin allergies, conditions, or sensitivities to cardiac patch.
• Exclusively retinal stroke or retinal TIA event.
• Pre-existing indication for anticoagulation (eg. History of mechanical heart valve replacement, deep vein thrombosis).
• Echocardiographic findings of congenital heart disease and endocarditis.
• Indicated for pacemaker, implantable cardiac defibrillator (ICD), CRT device, or an implantable hemodynamic monitoring system.
• Life expectancy \< 1 year for reasons other than stroke (eg. Metastatic cancer disease).

Egyéb

• Modified Rankin Scale ≥5 on index admission.
• Pre-existing contraindication for permanent anticoagulation (eg. hypocoagulable state).
• Pregnancy.

• Age ≥18 years.
• Diagnosis of acute ischemic stroke or transient ischemic attack (TIA) (WHO definition) of undetermined etiology made by neurologist within 7 days after the index event. The event must be either:
  • an ischemic stroke confirmed by neuroimaging; or
  • a TIA, defined as involving a focal unilateral motor deficit, speech/language deficit or hemianopia, with symptom duration \<24 hours (note: amaurosis fugax/ transient monocular blindness, pure sensory spells, isolated vertigo spells, etc. do not qualify for enrolment given the potential for misdiagnosis of such events).
• No AF detected in baseline 12-lead ECG on admission.
• The following diagnostic test have already been completed as part of clinical routine post-stroke/TIA:
  • Brain imaging with CT or MRI,
  • Transthoracic echocardiography to congenital heart disease and endocarditis.
• Recurrent stroke/TIA is inclusionary as long as patient meets inclusion/exclusion criteria for study enrolment.