Comparing Treatment Completion Of Daily Rifapentine & Isoniazid For One Month (1HP) To Weekly High Dose Rifapentine & Isoniazid For 3 Months (3HP) In Persons Living With HIV and in Household Contacts of Recently Diagnosed Tuberculosis Patients

Korábbi kezelés

• Confirmed or suspected TB disease (evidenced by symptoms and/or clinical exam findings and/or chest radiographic findings suggestive of TB, positive mycobacterial culture or molecular TB testing or currently on TB treatment for active TB disease)
• Previous treatment for active or latent TB for more than 30 days within the past 2 years
• Confirmed or suspected TB disease (evidenced by symptoms and/or clinical exam findings and/or chest radiographic findings suggestive of TB, positive mycobacterial culture or molecular TB testing or currently on TB treatment for active TB disease)
• Previous treatment for active or latent TB for >30 days within the past 2 years
• On prohibited medications

Más betegség

• Suspected acute hepatitis or known chronic or unstable liver disease\^
• On prohibited medications (see Appendix I)
  • Group 2: HIV-negative household contacts of an adult with confirmed pulmonary TB in Mozambique and Indonesia
• Suspected acute hepatitis or known chronic or unstable liver disease\^

Laborértékek

• ALT > 3 times the upper limit of normal (ULN)
• Total bilirubin > 2.5 times the ULN
• ALT > 3 times the upper limit of normal (ULN)
• Total bilirubin > 2.5 times the ULN

Egyéb

• Likely to move from the study area during the study period
• Known recent exposure to a TB case with resistance to isoniazid or rifampicin.
• On nevirapine, etravirine, rilpivirine, PI-based, or raltegravir-containing ART regimens
• Known sensitivity or intolerance to isoniazid or rifamycins
• Pregnancy or breastfeeding Females of childbearing potential who are unable or unwilling to use two forms of contraception**
• Likely to move from the study area during the study period
• Known exposure to TB cases with resistance to isoniazid or rifampicin in the source case
• Known sensitivity or intolerance to isoniazid or rifamycins
• Pregnancy or breastfeeding Females of childbearing potential who are unable or unwilling to use two forms of contraception**

• Age ≥ 13 years
• Weight > 30 kg
• HIV-seropositive
• HIV viral load <400 copies/mL, defined as "virally suppressed," on an EFV or DTG-based ART regimen (see Section 3.6.2)
• Candidates must meet WHO criteria for receiving TPT
• Age ≥ 13 years
• Weight > 30 kg
• HIV-negative
• Household contact of an adult with confirmed rifampicin-sensitive pulmonary TB
• Candidates must meet WHO criteria for receiving TPT

A regiszterben nem jelölt feltételek

• Group 1: HIV-positive adolescents and adults in South Africa and India